Matches in SemOpenAlex for { <https://semopenalex.org/work/W1990658906> ?p ?o ?g. }
- W1990658906 endingPage "e61280" @default.
- W1990658906 startingPage "e61280" @default.
- W1990658906 abstract "Analysis of positively-selected genes can help us understand how human evolved, especially the evolution of highly developed cognitive functions. However, previous works have reached conflicting conclusions regarding whether human neuronal genes are over-represented among genes under positive selection.We divided positively-selected genes into four groups according to the identification approaches, compiling a comprehensive list from 27 previous studies. We showed that genes that are highly expressed in the central nervous system are enriched in recent positive selection events in human history identified by intra-species genomic scan, especially in brain regions related to cognitive functions. This pattern holds when different datasets, parameters and analysis pipelines were used. Functional category enrichment analysis supported these findings, showing that synapse-related functions are enriched in genes under recent positive selection. In contrast, immune-related functions, for instance, are enriched in genes under ancient positive selection revealed by inter-species coding region comparison. We further demonstrated that most of these patterns still hold even after controlling for genomic characteristics that might bias genome-wide identification of positively-selected genes including gene length, gene density, GC composition, and intensity of negative selection.Our rigorous analysis resolved previous conflicting conclusions and revealed recent adaptation of human brain functions." @default.
- W1990658906 created "2016-06-24" @default.
- W1990658906 creator A5022243401 @default.
- W1990658906 creator A5042577846 @default.
- W1990658906 creator A5044129875 @default.
- W1990658906 creator A5044462814 @default.
- W1990658906 creator A5048549975 @default.
- W1990658906 creator A5090959358 @default.
- W1990658906 date "2013-04-09" @default.
- W1990658906 modified "2023-10-16" @default.
- W1990658906 title "Recent Adaptive Events in Human Brain Revealed by Meta-Analysis of Positively Selected Genes" @default.
- W1990658906 cites W1501643305 @default.
- W1990658906 cites W1529015533 @default.
- W1990658906 cites W1689369637 @default.
- W1990658906 cites W1972673599 @default.
- W1990658906 cites W1976844960 @default.
- W1990658906 cites W1982663312 @default.
- W1990658906 cites W1987378985 @default.
- W1990658906 cites W2000040240 @default.
- W1990658906 cites W2002500862 @default.
- W1990658906 cites W2002854942 @default.
- W1990658906 cites W2006189274 @default.
- W1990658906 cites W2009132217 @default.
- W1990658906 cites W2011933719 @default.
- W1990658906 cites W2025253353 @default.
- W1990658906 cites W2027938985 @default.
- W1990658906 cites W2030665408 @default.
- W1990658906 cites W2058763701 @default.
- W1990658906 cites W2068851900 @default.
- W1990658906 cites W2091203297 @default.
- W1990658906 cites W2096989813 @default.
- W1990658906 cites W2107934935 @default.
- W1990658906 cites W2109108939 @default.
- W1990658906 cites W2117140740 @default.
- W1990658906 cites W2117147132 @default.
- W1990658906 cites W2117790117 @default.
- W1990658906 cites W2120004345 @default.
- W1990658906 cites W2131636453 @default.
- W1990658906 cites W2138255346 @default.
- W1990658906 cites W21410603 @default.
- W1990658906 cites W2144410236 @default.
- W1990658906 cites W2152294954 @default.
- W1990658906 cites W2153686100 @default.
- W1990658906 cites W2154770881 @default.
- W1990658906 cites W2155804510 @default.
- W1990658906 cites W2156886335 @default.
- W1990658906 cites W2160697532 @default.
- W1990658906 cites W2163031152 @default.
- W1990658906 cites W2164683872 @default.
- W1990658906 cites W2167827709 @default.
- W1990658906 cites W2167852412 @default.
- W1990658906 cites W2168546553 @default.
- W1990658906 cites W4210347168 @default.
- W1990658906 cites W4294215472 @default.
- W1990658906 doi "https://doi.org/10.1371/journal.pone.0061280" @default.
- W1990658906 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3622023" @default.
- W1990658906 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23593450" @default.
- W1990658906 hasPublicationYear "2013" @default.
- W1990658906 type Work @default.
- W1990658906 sameAs 1990658906 @default.
- W1990658906 citedByCount "14" @default.
- W1990658906 countsByYear W19906589062012 @default.
- W1990658906 countsByYear W19906589062013 @default.
- W1990658906 countsByYear W19906589062014 @default.
- W1990658906 countsByYear W19906589062015 @default.
- W1990658906 countsByYear W19906589062017 @default.
- W1990658906 countsByYear W19906589062018 @default.
- W1990658906 countsByYear W19906589062019 @default.
- W1990658906 countsByYear W19906589062021 @default.
- W1990658906 crossrefType "journal-article" @default.
- W1990658906 hasAuthorship W1990658906A5022243401 @default.
- W1990658906 hasAuthorship W1990658906A5042577846 @default.
- W1990658906 hasAuthorship W1990658906A5044129875 @default.
- W1990658906 hasAuthorship W1990658906A5044462814 @default.
- W1990658906 hasAuthorship W1990658906A5048549975 @default.
- W1990658906 hasAuthorship W1990658906A5090959358 @default.
- W1990658906 hasBestOaLocation W19906589061 @default.
- W1990658906 hasConcept C104317684 @default.
- W1990658906 hasConcept C105565629 @default.
- W1990658906 hasConcept C116834253 @default.
- W1990658906 hasConcept C127716648 @default.
- W1990658906 hasConcept C139807058 @default.
- W1990658906 hasConcept C141231307 @default.
- W1990658906 hasConcept C154945302 @default.
- W1990658906 hasConcept C169760540 @default.
- W1990658906 hasConcept C197077220 @default.
- W1990658906 hasConcept C2777670902 @default.
- W1990658906 hasConcept C41008148 @default.
- W1990658906 hasConcept C54355233 @default.
- W1990658906 hasConcept C59822182 @default.
- W1990658906 hasConcept C70721500 @default.
- W1990658906 hasConcept C7386963 @default.
- W1990658906 hasConcept C75268714 @default.
- W1990658906 hasConcept C78458016 @default.
- W1990658906 hasConcept C81917197 @default.
- W1990658906 hasConcept C86803240 @default.
- W1990658906 hasConceptScore W1990658906C104317684 @default.
- W1990658906 hasConceptScore W1990658906C105565629 @default.