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• W1990664818 endingPage "27" @default.
• W1990664818 startingPage "19" @default.
• W1990664818 abstract "CD81 is expressed on most cells and is associated with other glycoproteins, including CD4 and CD8, to form multimolecular membrane complexes. Crosslinking of CD81 on TCRalphabeta(+) T cells results in costimulatory signals that have been proposed to be mediated via CD4 or CD8. In this study, we show that CD81 is also expressed on TCRgammadelta(+)CD4(-)CD8(-) T cells. CD81 crosslinking greatly enhanced anti-CD3 activation of both TCRalphabeta(+) (CD4+ and CD8+) and TCRgammadelta(+) T cells with regard to IFN-gamma production. However, crosslinking of CD81 molecules on TCRgammadelta(+) T cells, in the absence of anti-CD3 stimulation, resulted in cytokine production and enhanced IL-2-induced proliferation, demonstrating that physical association with CD4 or CD8 is not necessary for CD81 signaling. In contrast, crosslinking of CD81 on TCRalphabeta(+) T cells, in the absence of anti-CD3 stimulation, failed to activate these T cells. These results suggest that CD81 signaling may be mediated via a different mechanism(s) in TCRgammadelta(+) versus TCRalphabeta(+) T cells." @default.
• W1990664818 created "2016-06-24" @default.
• W1990664818 creator A5013089846 @default.
• W1990664818 creator A5079745468 @default.
• W1990664818 creator A5081394669 @default.
• W1990664818 date "2001-01-01" @default.
• W1990664818 modified "2023-09-29" @default.
• W1990664818 title "Crosslinking CD81 Results in Activation of TCRγδ T Cells" @default.
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• W1990664818 doi "https://doi.org/10.1006/cimm.2000.1744" @default.
• W1990664818 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11161449" @default.
• W1990664818 hasPublicationYear "2001" @default.
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