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• W1990668812 abstract "Naturally simian immunodeficiency virus (SIV)-infected sooty mangabeys do not progress to AIDS despite high-level virus replication. We previously showed that the fraction of CD4(+)CCR5(+) T cells is lower in sooty mangabeys compared to humans and macaques. Here we found that, after in vitro stimulation, sooty mangabey CD4(+) T cells fail to upregulate CCR5 and that this phenomenon is more pronounced in CD4(+) central memory T cells (T(CM) cells). CD4(+) T cell activation was similarly uncoupled from CCR5 expression in sooty mangabeys in vivo during acute SIV infection and the homeostatic proliferation that follows antibody-mediated CD4(+) T cell depletion. Sooty mangabey CD4(+) T(CM) cells that express low amounts of CCR5 showed reduced susceptibility to SIV infection both in vivo and in vitro when compared to CD4(+) T(CM) cells of rhesus macaques. These data suggest that low CCR5 expression on sooty mangabey CD4(+) T cells favors the preservation of CD4(+) T cell homeostasis and promotes an AIDS-free status by protecting CD4(+) T(CM) cells from direct virus infection." @default.
• W1990668812 created "2016-06-24" @default.
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• W1990668812 date "2011-06-26" @default.
• W1990668812 modified "2023-10-06" @default.
• W1990668812 title "Low levels of SIV infection in sooty mangabey central memory CD4+ T cells are associated with limited CCR5 expression" @default.
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• W1990668812 doi "https://doi.org/10.1038/nm.2395" @default.
• W1990668812 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3253129" @default.
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• W1990668812 hasPublicationYear "2011" @default.
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