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• W1990677072 endingPage "132" @default.
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• W1990677072 abstract "Summary The antimicrobial protein granulysin is considered to play an important role in the defence mechanism against bacterial infection. We previously reported that Acholeplasma laidlawii ‐induced transactivation of the granulysin promoter in a human monocytic cell line, THP‐1, is regulated by activator protein‐1 and CCAAT/enhancer binding protein‐β (C/EBPβ), but not by nuclear factor‐κB. Moreover, liver‐enriched transcriptional inhibitory protein (LIP), a C/EBPβ isoform, was strongly induced in A. laidlawii ‐stimulated THP‐1 cells. However, the level of liver‐enriched transcriptional activator protein (LAP), another C/EBPβ isoform, was essentially constant. Accordingly, we speculated that LIP would down‐regulate A. laidlawii ‐induced granulysin gene expression in THP‐1 cells. In the present study, we examined whether LAP augments A. laidlawii ‐induced granulysin gene expression using conditional LAP‐expressing THP‐1 cells in a tetracycline‐controlled expression system. Our results indicated that conditional expression of LAP augmented A. laidlawii ‐induced expression of granulysin mRNA. In addition, the granulysin protein was observed in A. laidlawii ‐stimulated, LAP‐expressing THP‐1 cells. Our results suggest that the expression of LAP plays a critical role in the expression of the granulysin gene in macrophages." @default.
• W1990677072 created "2016-06-24" @default.
• W1990677072 creator A5054949063 @default.
• W1990677072 creator A5057053876 @default.
• W1990677072 creator A5059138509 @default.
• W1990677072 date "2004-12-16" @default.
• W1990677072 modified "2023-10-15" @default.
• W1990677072 title "Conditional expression of liver-enriched transcriptional activator protein augments Acholeplasma laidlawii-induced granulysin gene expression in a human monocytic cell line, THP-1" @default.
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• W1990677072 doi "https://doi.org/10.1111/j.1365-2567.2004.02069.x" @default.
• W1990677072 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1782066" @default.
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• W1990677072 hasPublicationYear "2004" @default.
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