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- W1990677290 abstract "Alterations in default mode network (DMN) functional connectivity have been increasingly recognized in Alzheimer's disease (AD). This functional connectivity network comprises a characteristic set of brain regions which are among the earliest to show abnormal amyloid deposition (a key pathological feature of AD), specially the posterior cingulate cortex (PCC) and precuneus. However, the relationship between functional connectivity and PCC volume is not well known. We hypothesized that there is no linear relationship between anatomy and functional connectivity because of possible functional compensatory mechanisms which increase connectivity in early neurodegeneration. We evaluated 17 patients with mild AD and 24 healthy controls matched for gender and age. All subjects underwent a 10 minutes task-free fMRI at 3.0T. To identify the DMN, seed-based functional connectivity was calculated by placing a seed in the PCC and later calculated a Fisher's r-to-z transformation to obtain DMN statistical z-score maps. We also performed automatic volumetry of PCC by using Freesurfer software (version 5.0.1). We compared PCC volume and DMN mean connectivity between groups. Then, to verify if there is a correlation between, we performed simple linear as well as quadratic regressions between these values. We found significant differences both in DMN connectivity and PCC volumes between mild AD and controls (p<0.001). We did not find significant correlations between these variables when simple linear regressions were carried out. However, when we performed quadratic regressions, we found a significant correlation between these variables in mild AD group (p = 0.003, R-squared = 0.56 - Figure 1), but not in normal aging group." @default.
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- W1990677290 date "2013-07-01" @default.
- W1990677290 modified "2023-10-02" @default.
- W1990677290 title "P3-103: Relationship between anatomy and functional connectivity in default mode network in normal aging and mild Alzheimer's disease" @default.
- W1990677290 doi "https://doi.org/10.1016/j.jalz.2013.05.1174" @default.
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