Matches in SemOpenAlex for { <https://semopenalex.org/work/W1990683915> ?p ?o ?g. }
- W1990683915 endingPage "e23111" @default.
- W1990683915 startingPage "e23111" @default.
- W1990683915 abstract "Experimental evidence suggests that random, spontaneous (stochastic) fluctuations in gene expression have important biological consequences, including determination of cell fate and phenotypic variation within isogenic populations. We propose that fluctuations in gene expression represent a valuable tool to explore therapeutic strategies for patients who have suffered traumatic brain injury (TBI), for which there is no effective drug therapy. We have studied the effects of TBI on the hippocampus because TBI survivors commonly suffer cognitive problems that are associated with hippocampal damage. In our previous studies we separated dying and surviving hippocampal neurons by laser capture microdissection and observed unexplainable variations in post-TBI gene expression, even though dying and surviving neurons were adjacent and morphologically identical. We hypothesized that, in hippocampal neurons that subsequently are subjected to TBI, randomly increased pre-TBI expression of genes that are associated with neuroprotection predisposes neurons to survival; conversely, randomly decreased expression of these genes predisposes neurons to death. Thus, to identify genes that are associated with endogenous neuroprotection, we performed a comparative, high-resolution transcriptome analysis of dying and surviving hippocampal neurons in rats subjected to TBI. We found that surviving hippocampal neurons express a distinct molecular signature — increased expression of networks of genes that are associated with regeneration, cellular reprogramming, development, and synaptic plasticity. In dying neurons we found decreased expression of genes in those networks. Based on these data, we propose a hypothetical model in which hippocampal neuronal survival is determined by a rheostat that adds injury-induced genomic signals to expression of pro-survival genes, which pre-TBI varies randomly and spontaneously from neuron to neuron. We suggest that pharmacotherapeutic strategies that co-activate multiple survival signals and enhance self-repair mechanisms have the potential to shift the cell survival rheostat to favor survival and therefore improve functional outcome after TBI." @default.
- W1990683915 created "2016-06-24" @default.
- W1990683915 creator A5004165461 @default.
- W1990683915 creator A5018161688 @default.
- W1990683915 creator A5027678725 @default.
- W1990683915 creator A5028675538 @default.
- W1990683915 creator A5031101642 @default.
- W1990683915 creator A5054171562 @default.
- W1990683915 creator A5054951072 @default.
- W1990683915 creator A5060022521 @default.
- W1990683915 creator A5063020785 @default.
- W1990683915 creator A5068702104 @default.
- W1990683915 creator A5074034809 @default.
- W1990683915 creator A5077549041 @default.
- W1990683915 creator A5078521665 @default.
- W1990683915 creator A5089844959 @default.
- W1990683915 date "2011-08-11" @default.
- W1990683915 modified "2023-10-18" @default.
- W1990683915 title "Influence of Stochastic Gene Expression on the Cell Survival Rheostat after Traumatic Brain Injury" @default.
- W1990683915 cites W1617220029 @default.
- W1990683915 cites W1942961343 @default.
- W1990683915 cites W1964420796 @default.
- W1990683915 cites W1966798058 @default.
- W1990683915 cites W1972878774 @default.
- W1990683915 cites W1974773432 @default.
- W1990683915 cites W1975518740 @default.
- W1990683915 cites W1976422798 @default.
- W1990683915 cites W1977320782 @default.
- W1990683915 cites W1977860760 @default.
- W1990683915 cites W1979369962 @default.
- W1990683915 cites W1981262837 @default.
- W1990683915 cites W1986934921 @default.
- W1990683915 cites W1988151613 @default.
- W1990683915 cites W1988163167 @default.
- W1990683915 cites W1989058637 @default.
- W1990683915 cites W1991929148 @default.
- W1990683915 cites W2003643542 @default.
- W1990683915 cites W2005800358 @default.
- W1990683915 cites W2013848047 @default.
- W1990683915 cites W2016645588 @default.
- W1990683915 cites W2019100219 @default.
- W1990683915 cites W2019103111 @default.
- W1990683915 cites W2019684651 @default.
- W1990683915 cites W2020297346 @default.
- W1990683915 cites W2026985565 @default.
- W1990683915 cites W2027276122 @default.
- W1990683915 cites W2030860399 @default.
- W1990683915 cites W2041183431 @default.
- W1990683915 cites W2041277643 @default.
- W1990683915 cites W2041703014 @default.
- W1990683915 cites W2041945875 @default.
- W1990683915 cites W2044192863 @default.
- W1990683915 cites W2044638670 @default.
- W1990683915 cites W2046831727 @default.
- W1990683915 cites W2047031939 @default.
- W1990683915 cites W2047148152 @default.
- W1990683915 cites W2048376025 @default.
- W1990683915 cites W2054536322 @default.
- W1990683915 cites W2055165982 @default.
- W1990683915 cites W2072477505 @default.
- W1990683915 cites W2073303427 @default.
- W1990683915 cites W2074125037 @default.
- W1990683915 cites W2082206533 @default.
- W1990683915 cites W2082547168 @default.
- W1990683915 cites W2083540239 @default.
- W1990683915 cites W2088359631 @default.
- W1990683915 cites W2089178573 @default.
- W1990683915 cites W2091198609 @default.
- W1990683915 cites W2091389527 @default.
- W1990683915 cites W2091901410 @default.
- W1990683915 cites W2095105459 @default.
- W1990683915 cites W2096015757 @default.
- W1990683915 cites W2096592089 @default.
- W1990683915 cites W2103717170 @default.
- W1990683915 cites W2106095767 @default.
- W1990683915 cites W2110612987 @default.
- W1990683915 cites W2114870653 @default.
- W1990683915 cites W2119210693 @default.
- W1990683915 cites W2123184492 @default.
- W1990683915 cites W2123491442 @default.
- W1990683915 cites W2123701707 @default.
- W1990683915 cites W2129789527 @default.
- W1990683915 cites W2131581438 @default.
- W1990683915 cites W2132980978 @default.
- W1990683915 cites W2133943800 @default.
- W1990683915 cites W2136609246 @default.
- W1990683915 cites W2138152051 @default.
- W1990683915 cites W2142374646 @default.
- W1990683915 cites W2146394305 @default.
- W1990683915 cites W2150551377 @default.
- W1990683915 cites W2156188912 @default.
- W1990683915 cites W2157683935 @default.
- W1990683915 cites W2161830466 @default.
- W1990683915 cites W2163006694 @default.
- W1990683915 cites W2166660871 @default.
- W1990683915 cites W2167089957 @default.
- W1990683915 cites W2167266338 @default.
- W1990683915 cites W2168221215 @default.