FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1990687924> ?p ?o ?g. }

• W1990687924 endingPage "841" @default.
• W1990687924 startingPage "833" @default.
• W1990687924 abstract "Aging is associated with dramatic reductions in sleep continuity and sleep intensity. Since gaboxadol, a selective GABA(A) receptor agonist, has been demonstrated to improve sleep consolidation and promote deep sleep, it may be an effective hypnotic, particularly for elderly patients with insomnia. In the present study, we investigated the effects of subchronic gaboxadol administration on nocturnal sleep and its residual effects during the next days in elderly subjects. This was a randomized, double-blind, placebo-controlled, balanced crossover study in 10 healthy elderly subjects without sleep complaints. The subjects were administered either placebo or 15 mg gaboxadol hydrochloride at bedtime on three consecutive nights. Sleep was recorded during each night from 2300 to 0700 h and tests assessing attention (target detection, stroop test) and memory function (visual form recognition, immediate word recall, digit span) were applied at 0900, 1400, and 1700 h during the following days. Compared with placebo, gaboxadol significantly shortened subjective sleep onset latency and increased self-rated sleep intensity and quality. Polysomnographic recordings showed that it significantly decreased the number of awakenings, the amount of intermittent wakefulness, and stage 1, and increased slow wave sleep and stage 2. These effects were stable over the three nights. None of the subjects reported side effects. Next-day cognitive performance was not affected by gaboxadol. Gaboxadol persistently improved subjective and objective sleep quality and was devoid of residual effects. Thus, at the employed dose, it seems an effective hypnotic in elderly subjects." @default.
• W1990687924 created "2016-06-24" @default.
• W1990687924 creator A5010209530 @default.
• W1990687924 creator A5011152416 @default.
• W1990687924 creator A5015060244 @default.
• W1990687924 creator A5024254467 @default.
• W1990687924 date "2004-12-15" @default.
• W1990687924 modified "2023-10-11" @default.
• W1990687924 title "Effect of Repeated Gaboxadol Administration on Night Sleep and Next-Day Performance in Healthy Elderly Subjects" @default.
• W1990687924 cites W1498112602 @default.
• W1990687924 cites W1703472577 @default.
• W1990687924 cites W178313491 @default.
• W1990687924 cites W182717727 @default.
• W1990687924 cites W1965376023 @default.
• W1990687924 cites W19767432 @default.
• W1990687924 cites W1980615352 @default.
• W1990687924 cites W1989203969 @default.
• W1990687924 cites W2009090546 @default.
• W1990687924 cites W2009458733 @default.
• W1990687924 cites W2030829605 @default.
• W1990687924 cites W2040059704 @default.
• W1990687924 cites W2040502857 @default.
• W1990687924 cites W2048191327 @default.
• W1990687924 cites W2051589707 @default.
• W1990687924 cites W2058391632 @default.
• W1990687924 cites W2061879267 @default.
• W1990687924 cites W2082587776 @default.
• W1990687924 cites W2088235234 @default.
• W1990687924 cites W2093289117 @default.
• W1990687924 cites W2096176716 @default.
• W1990687924 cites W2139602820 @default.
• W1990687924 cites W2158766477 @default.
• W1990687924 cites W2171776652 @default.
• W1990687924 cites W2395141605 @default.
• W1990687924 cites W4366064309 @default.
• W1990687924 cites W73680102 @default.
• W1990687924 cites W761239894 @default.
• W1990687924 cites W80032083 @default.
• W1990687924 doi "https://doi.org/10.1038/sj.npp.1300641" @default.
• W1990687924 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15602499" @default.
• W1990687924 hasPublicationYear "2004" @default.
• W1990687924 type Work @default.
• W1990687924 sameAs 1990687924 @default.
• W1990687924 citedByCount "63" @default.
• W1990687924 countsByYear W19906879242013 @default.
• W1990687924 countsByYear W19906879242014 @default.
• W1990687924 countsByYear W19906879242015 @default.
• W1990687924 countsByYear W19906879242016 @default.
• W1990687924 countsByYear W19906879242017 @default.
• W1990687924 countsByYear W19906879242019 @default.
• W1990687924 countsByYear W19906879242020 @default.
• W1990687924 countsByYear W19906879242021 @default.
• W1990687924 countsByYear W19906879242023 @default.
• W1990687924 crossrefType "journal-article" @default.
• W1990687924 hasAuthorship W1990687924A5010209530 @default.
• W1990687924 hasAuthorship W1990687924A5011152416 @default.
• W1990687924 hasAuthorship W1990687924A5015060244 @default.
• W1990687924 hasAuthorship W1990687924A5024254467 @default.
• W1990687924 hasBestOaLocation W19906879241 @default.
• W1990687924 hasConcept C110539466 @default.
• W1990687924 hasConcept C118552586 @default.
• W1990687924 hasConcept C121446783 @default.
• W1990687924 hasConcept C126322002 @default.
• W1990687924 hasConcept C142724271 @default.
• W1990687924 hasConcept C15744967 @default.
• W1990687924 hasConcept C204787440 @default.
• W1990687924 hasConcept C27081682 @default.
• W1990687924 hasConcept C2778329153 @default.
• W1990687924 hasConcept C2778537899 @default.
• W1990687924 hasConcept C2778910407 @default.
• W1990687924 hasConcept C2778996325 @default.
• W1990687924 hasConcept C2780930544 @default.
• W1990687924 hasConcept C2781210498 @default.
• W1990687924 hasConcept C42219234 @default.
• W1990687924 hasConcept C522805319 @default.
• W1990687924 hasConcept C63759246 @default.
• W1990687924 hasConcept C71924100 @default.
• W1990687924 hasConcept C87813604 @default.
• W1990687924 hasConceptScore W1990687924C110539466 @default.
• W1990687924 hasConceptScore W1990687924C118552586 @default.
• W1990687924 hasConceptScore W1990687924C121446783 @default.
• W1990687924 hasConceptScore W1990687924C126322002 @default.
• W1990687924 hasConceptScore W1990687924C142724271 @default.
• W1990687924 hasConceptScore W1990687924C15744967 @default.
• W1990687924 hasConceptScore W1990687924C204787440 @default.
• W1990687924 hasConceptScore W1990687924C27081682 @default.
• W1990687924 hasConceptScore W1990687924C2778329153 @default.
• W1990687924 hasConceptScore W1990687924C2778537899 @default.
• W1990687924 hasConceptScore W1990687924C2778910407 @default.
• W1990687924 hasConceptScore W1990687924C2778996325 @default.
• W1990687924 hasConceptScore W1990687924C2780930544 @default.
• W1990687924 hasConceptScore W1990687924C2781210498 @default.
• W1990687924 hasConceptScore W1990687924C42219234 @default.
• W1990687924 hasConceptScore W1990687924C522805319 @default.
• W1990687924 hasConceptScore W1990687924C63759246 @default.
• W1990687924 hasConceptScore W1990687924C71924100 @default.
• W1990687924 hasConceptScore W1990687924C87813604 @default.
• W1990687924 hasIssue "4" @default.

• next