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• W1990688097 abstract "ABSTRACT Escherichia coli K-12 suffers acetic acid stress during prolonged incubation in glucose minimal medium containing a limiting concentration of inorganic phosphate (0.1 mM P i ), which decreases the number of viable cells from 6 × 10 8 to ≤10 CFU/ml between days 6 and 14 of incubation. Here we show that following two serial transfers into P i -limiting medium, evolved mutants survived prolonged incubation (≈10 7 CFU/ml on day 14 of incubation). The evolved strains that overtook the populations were generally PhnE + , whereas the ancestral K-12 strain carries an inactive phnE allele, which prevents the transport of phosphonates. The switching in phnE occurred with a high frequency as a result of the deletion of an 8-bp repeated sequence. In a mixed culture starved for P i that contained the K-12 ancestral strain in majority, evolved strains grew through PhnE-dependent scavenging of probably organic phosphate esters (not phosphonates or P i ) released by E. coli K-12 between days 1 and 3, before acetic acid excreted by E. coli K-12 reached toxic levels. The growth yield of phnE + strains in mixed culture was dramatically enhanced by mutations that affect glucose metabolism, such as an rpoS mutation inactivating the alternative sigma factor RpoS. The long-term viability of evolved populations was generally higher when the ancestral strain carried an inactive rather than an active phnE allele, which indicates that cross-feeding of phosphorylated products as a result of the phnE polymorphism may be essential for the spread of mutants which eventually help populations to survive under P i starvation conditions." @default.
• W1990688097 created "2016-06-24" @default.
• W1990688097 creator A5012464814 @default.
• W1990688097 creator A5026961597 @default.
• W1990688097 date "2012-01-15" @default.
• W1990688097 modified "2023-09-25" @default.
• W1990688097 title "Activation of the Cryptic PhnE Permease Promotes Rapid Adaptive Evolution in a Population of Escherichia coli K-12 Starved for Phosphate" @default.
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• W1990688097 doi "https://doi.org/10.1128/jb.06094-11" @default.
• W1990688097 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3256660" @default.
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• W1990688097 hasPublicationYear "2012" @default.
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