FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1990688974> ?p ?o ?g. }

• W1990688974 endingPage "355" @default.
• W1990688974 startingPage "347" @default.
• W1990688974 abstract "Hepatocyte assays, routinely used to assess the metabolic stability of new chemical entities, were recently improved by using hepatocytes in suspension instead of primary cultures [N. Blanchard, L. Richert, B. Notter, F. Delobel, P. David, P. Coassolo, T. Lavé, Impact of serum on clearance predictions obtained from suspensions and primary cultures of rat hepatocytes, Eur. J. Pharm. Sci. 23 (2004) 189–199]. The aim of the present study was to investigate miniaturising the suspension assay by using cryopreserved human hepatocytes, i.e., 150,000 cells/well in 96-well plates, to predict hepatic clearance (CLH) in order to increase compound throughput and decrease cost and tissue requirements. For this, an evaluation was first carried out with rat hepatocytes. Then, human hepatocytes from various donors were used under these predetermined conditions, either immediately after isolation, either after a 20-h-cold storage period in UW or after cryopreservation. The values of CLint and CLH determined using human hepatocytes in suspension in 96-well plates, immediately after isolation, after cold storage or after cryopreservation, were comparable to those obtained with hepatocytes in primary culture. In particular, the use of cryopreserved human hepatocytes in suspension in a 96-well format appeared to be largely satisfactory as a tool for screening and ranking of compounds in the early phase of the drug discovery process." @default.
• W1990688974 created "2016-06-24" @default.
• W1990688974 creator A5009236384 @default.
• W1990688974 creator A5012281177 @default.
• W1990688974 creator A5012795625 @default.
• W1990688974 creator A5025762022 @default.
• W1990688974 creator A5044090708 @default.
• W1990688974 creator A5049584417 @default.
• W1990688974 creator A5052801391 @default.
• W1990688974 creator A5075225535 @default.
• W1990688974 creator A5080009533 @default.
• W1990688974 date "2006-07-01" @default.
• W1990688974 modified "2023-10-17" @default.
• W1990688974 title "Cryopreserved human hepatocytes in suspension are a convenient high throughput tool for the prediction of metabolic clearance" @default.
• W1990688974 cites W119374870 @default.
• W1990688974 cites W188427797 @default.
• W1990688974 cites W1977626881 @default.
• W1990688974 cites W1978504225 @default.
• W1990688974 cites W1982311374 @default.
• W1990688974 cites W1987020046 @default.
• W1990688974 cites W1987044402 @default.
• W1990688974 cites W2000585507 @default.
• W1990688974 cites W2005101461 @default.
• W1990688974 cites W2010136297 @default.
• W1990688974 cites W2016269688 @default.
• W1990688974 cites W2027413685 @default.
• W1990688974 cites W2031561405 @default.
• W1990688974 cites W2031641590 @default.
• W1990688974 cites W2042394561 @default.
• W1990688974 cites W2046726491 @default.
• W1990688974 cites W2066439022 @default.
• W1990688974 cites W2080456908 @default.
• W1990688974 cites W2089338956 @default.
• W1990688974 cites W2092111972 @default.
• W1990688974 cites W2107257507 @default.
• W1990688974 cites W2112247582 @default.
• W1990688974 cites W2116796907 @default.
• W1990688974 cites W2118208123 @default.
• W1990688974 cites W2119678057 @default.
• W1990688974 cites W2150094018 @default.
• W1990688974 cites W2150284616 @default.
• W1990688974 cites W2159730986 @default.
• W1990688974 cites W2160153148 @default.
• W1990688974 cites W4241401467 @default.
• W1990688974 cites W4248572201 @default.
• W1990688974 cites W68169567 @default.
• W1990688974 doi "https://doi.org/10.1016/j.ejpb.2006.01.014" @default.
• W1990688974 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16621491" @default.
• W1990688974 hasPublicationYear "2006" @default.
• W1990688974 type Work @default.
• W1990688974 sameAs 1990688974 @default.
• W1990688974 citedByCount "34" @default.
• W1990688974 countsByYear W19906889742012 @default.
• W1990688974 countsByYear W19906889742013 @default.
• W1990688974 countsByYear W19906889742014 @default.
• W1990688974 countsByYear W19906889742016 @default.
• W1990688974 countsByYear W19906889742017 @default.
• W1990688974 countsByYear W19906889742020 @default.
• W1990688974 countsByYear W19906889742022 @default.
• W1990688974 crossrefType "journal-article" @default.
• W1990688974 hasAuthorship W1990688974A5009236384 @default.
• W1990688974 hasAuthorship W1990688974A5012281177 @default.
• W1990688974 hasAuthorship W1990688974A5012795625 @default.
• W1990688974 hasAuthorship W1990688974A5025762022 @default.
• W1990688974 hasAuthorship W1990688974A5044090708 @default.
• W1990688974 hasAuthorship W1990688974A5049584417 @default.
• W1990688974 hasAuthorship W1990688974A5052801391 @default.
• W1990688974 hasAuthorship W1990688974A5075225535 @default.
• W1990688974 hasAuthorship W1990688974A5080009533 @default.
• W1990688974 hasConcept C105341887 @default.
• W1990688974 hasConcept C153911025 @default.
• W1990688974 hasConcept C179933525 @default.
• W1990688974 hasConcept C185592680 @default.
• W1990688974 hasConcept C196843134 @default.
• W1990688974 hasConcept C202444582 @default.
• W1990688974 hasConcept C202751555 @default.
• W1990688974 hasConcept C2776200302 @default.
• W1990688974 hasConcept C33923547 @default.
• W1990688974 hasConcept C55493867 @default.
• W1990688974 hasConcept C5961521 @default.
• W1990688974 hasConcept C86803240 @default.
• W1990688974 hasConcept C95444343 @default.
• W1990688974 hasConceptScore W1990688974C105341887 @default.
• W1990688974 hasConceptScore W1990688974C153911025 @default.
• W1990688974 hasConceptScore W1990688974C179933525 @default.
• W1990688974 hasConceptScore W1990688974C185592680 @default.
• W1990688974 hasConceptScore W1990688974C196843134 @default.
• W1990688974 hasConceptScore W1990688974C202444582 @default.
• W1990688974 hasConceptScore W1990688974C202751555 @default.
• W1990688974 hasConceptScore W1990688974C2776200302 @default.
• W1990688974 hasConceptScore W1990688974C33923547 @default.
• W1990688974 hasConceptScore W1990688974C55493867 @default.
• W1990688974 hasConceptScore W1990688974C5961521 @default.
• W1990688974 hasConceptScore W1990688974C86803240 @default.
• W1990688974 hasConceptScore W1990688974C95444343 @default.
• W1990688974 hasIssue "3" @default.
• W1990688974 hasLocation W19906889741 @default.
• W1990688974 hasLocation W19906889742 @default.

• next