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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1990691343> ?p ?o ?g. }

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• W1990691343 abstract "Most human T cell lymphotropic virus type (HTLV)-1-infected individuals mount a strong and persistently activated cytotoxic T lymphocyte (CTL) response to the virus, which implies that there is abundant chronic transcription of HTLV-1 genes. On the other hand, several observations suggest that HTLV-1 might be latent in vivo and therefore not detectable by CTLs. To clarify these discrepancies, we quantified the frequency of provirus-positive peripheral blood mononuclear cells (PBMCs) that were capable of expressing the HTLV-1 Tax protein, which is known to be the immunodominant target antigen recognized by HTLV-1-specific CTLs. The analysis showed that a significant proportion of HTLV-1-infected cells (from 14 to 100%) starts to express the Tax protein within a few hours of culture ex vivo. Phenotypic analysis confirmed that the main cell subpopulation expressing the Tax protein is CD4 positive. Frequent Tax expression in CD4(+) T lymphocytes in vivo might account for the chronic activation of the cytotoxic immune response observed in the majority of HTLV-1-infected patients and might contribute to the pathogenesis of HTLV-1-associated diseases." @default.
• W1990691343 created "2016-06-24" @default.
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• W1990691343 date "2000-11-01" @default.
• W1990691343 modified "2023-10-02" @default.
• W1990691343 title "High Frequency of Viral Protein Expression in Human T Cell Lymphotropic Virus Type 1-Infected Peripheral Blood Mononuclear Cells" @default.
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• W1990691343 doi "https://doi.org/10.1089/08892220050193191" @default.
• W1990691343 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11080815" @default.
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