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- W1990695168 endingPage "1678" @default.
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- W1990695168 abstract "The field of synthetic biology seeks to engineer reliable and predictable behaviors in organisms from collections of standardized genetic parts. However, unlike other types of machines, genetically encoded biological systems are prone to changes in their designed sequences due to mutations in their DNA sequences after these devices are constructed and deployed. Thus, biological engineering efforts can be confounded by undesired evolution that rapidly breaks the functions of parts and systems, particularly when they are costly to the host cell to maintain. Here, we explain the fundamental properties that determine the evolvability of biological systems. Then, we use this framework to review current efforts to engineer the DNA sequences that encode synthetic biology devices and the genomes of their microbial hosts to reduce their ability to evolve and therefore increase their genetic reliability so that they maintain their intended functions over longer timescales." @default.
- W1990695168 created "2016-06-24" @default.
- W1990695168 creator A5014716649 @default.
- W1990695168 creator A5038574763 @default.
- W1990695168 creator A5079232304 @default.
- W1990695168 date "2014-01-01" @default.
- W1990695168 modified "2023-10-16" @default.
- W1990695168 title "Engineering reduced evolutionary potential for synthetic biology" @default.
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- W1990695168 doi "https://doi.org/10.1039/c3mb70606k" @default.
- W1990695168 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4043932" @default.