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• W1990700901 abstract "<i>Objective:</i> The purpose of this study was to examine the efficacy and toxicity of treating small arteriovenous malformations (AVMs) (≤3 cm in diameter) with a median marginal applied dose of 14 Gy. <i>Methods:</i> Two hundred and thirteen patients diagnosed with AVMs were treated between January 1991 and December 2005. Seventy-three percent of the patients had hemorrhaged prior to treatment, 13% had had previous surgery and 19.2% had had previous embolization. The median follow-up duration was 48.1 months. <i>Results:</i> The Kaplan-Meier analysis estimated that the 36-month obliteration rate was 65.5% for patients undergoing their first stereotactic radiosurgery (SRS) and 68.3% for those undergoing repeated SRS. The Kaplan-Meier analysis estimated the 60-month AVMs obliteration rate for the entire cohort to be 82.4%. The median time to AVM obliteration was 40 ± 2.8 months. We found a statistically significant relationship between the time of obliteration and the following factors: site of the AVMs (sites other than brainstem), a higher prescribed dose and a positive history of previous hemorrhage. Thirteen patients (7.6%) experienced toxicities. <i>Conclusions:</i> SRS was an effective and safe treatment for AVMs ≤3 cm in diameter, with acceptable toxicity." @default.
• W1990700901 created "2016-06-24" @default.
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• W1990700901 date "2011-01-01" @default.
• W1990700901 modified "2023-09-27" @default.
• W1990700901 title "Linac Stereotactic Radiosurgery for the Treatment of Small Arteriovenous Malformations: Lower Doses Can Be Equally Effective" @default.
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• W1990700901 doi "https://doi.org/10.1159/000330837" @default.
• W1990700901 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22005899" @default.
• W1990700901 hasPublicationYear "2011" @default.
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