Matches in SemOpenAlex for { <https://semopenalex.org/work/W1990703564> ?p ?o ?g. }
- W1990703564 endingPage "8" @default.
- W1990703564 startingPage "1" @default.
- W1990703564 abstract "Autologous osteochondral transplantation (AOT) is a method for articular cartilage repair. However, several disadvantages of this method have been reported, such as transplanted cartilage degeneration and the lack of a connection between the grafted and adjacent cartilage tissues. To evaluate the effect of intra-articular administration of trichostatin A (TSA) on AOT, we conducted a case control study in a rabbit model. International Cartilage Repair Society (ICRS) macroscopic scores, the modified O’Driscoll histology scores, and real-time PCR were utilized to evaluate the results. At 4 weeks, both macroscopic and histological assessments showed that there was no significant difference between the TSA and control groups. However, the mean macroscopic and histological scores for the TSA-treated group were significantly higher than the scores for the control group at 12 weeks. TSA was shown to directly reduce collagen type II (COL2), aggrecan, matrix metalloproteinase (MMP), and a disintegrin and metalloproteinase domain with thrombospondin motifs 5 (ADAMTS-5) expression and to simultaneously repress the upregulation of MMP-3, MMP-9, and MMP-13 levels induced by interleukin 1 β (IL-1 β ) in chondrocytes. In conclusion, TSA protects AOT grafts from degeneration, which may provide a benefit in the repair of articular cartilage injury." @default.
- W1990703564 created "2016-06-24" @default.
- W1990703564 creator A5003673377 @default.
- W1990703564 creator A5011156622 @default.
- W1990703564 creator A5015693631 @default.
- W1990703564 creator A5030703972 @default.
- W1990703564 creator A5036906421 @default.
- W1990703564 creator A5049981926 @default.
- W1990703564 creator A5058223300 @default.
- W1990703564 creator A5062380753 @default.
- W1990703564 creator A5065479119 @default.
- W1990703564 date "2015-01-01" @default.
- W1990703564 modified "2023-10-12" @default.
- W1990703564 title "Influence of Intra-Articular Administration of Trichostatin A on Autologous Osteochondral Transplantation in a Rabbit Model" @default.
- W1990703564 cites W1687504009 @default.
- W1990703564 cites W179053432 @default.
- W1990703564 cites W1942341118 @default.
- W1990703564 cites W1970796511 @default.
- W1990703564 cites W1983766555 @default.
- W1990703564 cites W1993521092 @default.
- W1990703564 cites W2008368193 @default.
- W1990703564 cites W2010231609 @default.
- W1990703564 cites W2016057024 @default.
- W1990703564 cites W2019909260 @default.
- W1990703564 cites W2020463362 @default.
- W1990703564 cites W2034460461 @default.
- W1990703564 cites W2038773696 @default.
- W1990703564 cites W2056211028 @default.
- W1990703564 cites W2065497694 @default.
- W1990703564 cites W2067317498 @default.
- W1990703564 cites W2076868785 @default.
- W1990703564 cites W2081600388 @default.
- W1990703564 cites W2082981442 @default.
- W1990703564 cites W2087838524 @default.
- W1990703564 cites W2109305602 @default.
- W1990703564 cites W2112894128 @default.
- W1990703564 cites W2143735635 @default.
- W1990703564 cites W2153268309 @default.
- W1990703564 cites W2160161140 @default.
- W1990703564 cites W2167415368 @default.
- W1990703564 cites W2178069657 @default.
- W1990703564 cites W2410056848 @default.
- W1990703564 cites W2418900982 @default.
- W1990703564 cites W2438834715 @default.
- W1990703564 cites W40572262 @default.
- W1990703564 cites W1983806720 @default.
- W1990703564 cites W2012771283 @default.
- W1990703564 doi "https://doi.org/10.1155/2015/470934" @default.
- W1990703564 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4381848" @default.
- W1990703564 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25866784" @default.
- W1990703564 hasPublicationYear "2015" @default.
- W1990703564 type Work @default.
- W1990703564 sameAs 1990703564 @default.
- W1990703564 citedByCount "1" @default.
- W1990703564 countsByYear W19907035642017 @default.
- W1990703564 crossrefType "journal-article" @default.
- W1990703564 hasAuthorship W1990703564A5003673377 @default.
- W1990703564 hasAuthorship W1990703564A5011156622 @default.
- W1990703564 hasAuthorship W1990703564A5015693631 @default.
- W1990703564 hasAuthorship W1990703564A5030703972 @default.
- W1990703564 hasAuthorship W1990703564A5036906421 @default.
- W1990703564 hasAuthorship W1990703564A5049981926 @default.
- W1990703564 hasAuthorship W1990703564A5058223300 @default.
- W1990703564 hasAuthorship W1990703564A5062380753 @default.
- W1990703564 hasAuthorship W1990703564A5065479119 @default.
- W1990703564 hasBestOaLocation W19907035641 @default.
- W1990703564 hasConcept C104317684 @default.
- W1990703564 hasConcept C105702510 @default.
- W1990703564 hasConcept C109523444 @default.
- W1990703564 hasConcept C126322002 @default.
- W1990703564 hasConcept C141071460 @default.
- W1990703564 hasConcept C142724271 @default.
- W1990703564 hasConcept C16685009 @default.
- W1990703564 hasConcept C167814343 @default.
- W1990703564 hasConcept C185592680 @default.
- W1990703564 hasConcept C197534660 @default.
- W1990703564 hasConcept C204787440 @default.
- W1990703564 hasConcept C2776164576 @default.
- W1990703564 hasConcept C2776224515 @default.
- W1990703564 hasConcept C2777865847 @default.
- W1990703564 hasConcept C2778305200 @default.
- W1990703564 hasConcept C2780550940 @default.
- W1990703564 hasConcept C2781013607 @default.
- W1990703564 hasConcept C2781403057 @default.
- W1990703564 hasConcept C2910007452 @default.
- W1990703564 hasConcept C2911091166 @default.
- W1990703564 hasConcept C3020332539 @default.
- W1990703564 hasConcept C55493867 @default.
- W1990703564 hasConcept C55728118 @default.
- W1990703564 hasConcept C64927066 @default.
- W1990703564 hasConcept C71924100 @default.
- W1990703564 hasConceptScore W1990703564C104317684 @default.
- W1990703564 hasConceptScore W1990703564C105702510 @default.
- W1990703564 hasConceptScore W1990703564C109523444 @default.
- W1990703564 hasConceptScore W1990703564C126322002 @default.
- W1990703564 hasConceptScore W1990703564C141071460 @default.
- W1990703564 hasConceptScore W1990703564C142724271 @default.
- W1990703564 hasConceptScore W1990703564C16685009 @default.