FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1990704706> ?p ?o ?g. }

• W1990704706 endingPage "181" @default.
• W1990704706 startingPage "170" @default.
• W1990704706 abstract "Adenylyl cyclase (AC) is an effector molecule in beta-adrenergic receptor signaling, catalyzing conversion of ATP to cAMP. Agents that increase intracellular levels of cAMP have been used previously to treat clinical heart failure. Recently, Roth et al. have shown that long-term cardiac-directed expression of ACVI, a dominant AC isoform in mammalian cardiac myocytes, increases survival and abrogates myocardial hypertrophy in transgenic (TG) mice with Galphaq-associated cardiomyopathy. Indeed, it has been proposed that increasing the cardiac content of ACVI is fundamentally different than other strategies used to increase cAMP function. However, one important but unexplored issue is its effects on electrical remodeling. Electrophysiological properties of Galphaq mice have been characterized. Similar to other models of cardiac hypertrophy and failure, cardiac myocytes isolated from Galphaq mice show prolonged action potential with reduced transient outward K+ current (Ito) and inward rectifier K+ current (IK1) density compare to wild-type (WT) animals. We directly examined the electrical remodeling of cardiac-directed ACVI over-expression in Galphaq mice using ECG recordings and whole-cell patch-clamp recordings. Four groups of animals were used: WT (double negative), ACVI, Galphaq and double positive TG mice (Galphaq/ACVI). Cardiac-directed expression of ACVI results in the reversal of adverse electrical remodeling in the Galphaq mice and is associated with significant improvement in the delay of cardiac repolarization and arrhythmias. Specifically, there is a normalization of Ito, IK1 and action potential duration in Galphaq/ACVI compared to Galphaq mice. In summary, our data provide evidence that increased cardiac ACVI content has a salutary effect in cardiomyopathy and cardiac electrical remodeling." @default.
• W1990704706 created "2016-06-24" @default.
• W1990704706 creator A5013255314 @default.
• W1990704706 creator A5031817215 @default.
• W1990704706 creator A5034957704 @default.
• W1990704706 creator A5051781429 @default.
• W1990704706 creator A5055778361 @default.
• W1990704706 creator A5058492487 @default.
• W1990704706 creator A5088989762 @default.
• W1990704706 date "2006-07-01" @default.
• W1990704706 modified "2023-09-27" @default.
• W1990704706 title "Cardiac-directed expression of adenylyl cyclase reverses electrical remodeling in cardiomyopathy" @default.
• W1990704706 cites W1533702935 @default.
• W1990704706 cites W1548554375 @default.
• W1990704706 cites W1578024134 @default.
• W1990704706 cites W1590540783 @default.
• W1990704706 cites W1606703336 @default.
• W1990704706 cites W1928342325 @default.
• W1990704706 cites W1964485054 @default.
• W1990704706 cites W1966331438 @default.
• W1990704706 cites W1970329745 @default.
• W1990704706 cites W1976675209 @default.
• W1990704706 cites W1976677443 @default.
• W1990704706 cites W1978545009 @default.
• W1990704706 cites W1983920157 @default.
• W1990704706 cites W1992890921 @default.
• W1990704706 cites W1994103758 @default.
• W1990704706 cites W2007098938 @default.
• W1990704706 cites W2009667219 @default.
• W1990704706 cites W2011338378 @default.
• W1990704706 cites W2017405129 @default.
• W1990704706 cites W2025179622 @default.
• W1990704706 cites W2046846631 @default.
• W1990704706 cites W2055719302 @default.
• W1990704706 cites W2068711984 @default.
• W1990704706 cites W2071092788 @default.
• W1990704706 cites W2072621146 @default.
• W1990704706 cites W2086578266 @default.
• W1990704706 cites W2097340844 @default.
• W1990704706 cites W2097360067 @default.
• W1990704706 cites W2099757528 @default.
• W1990704706 cites W2103940141 @default.
• W1990704706 cites W2107992067 @default.
• W1990704706 cites W2112079413 @default.
• W1990704706 cites W2113176279 @default.
• W1990704706 cites W2113934901 @default.
• W1990704706 cites W2116169862 @default.
• W1990704706 cites W2116483248 @default.
• W1990704706 cites W2117487814 @default.
• W1990704706 cites W2118727366 @default.
• W1990704706 cites W2128382203 @default.
• W1990704706 cites W2129439677 @default.
• W1990704706 cites W2130678592 @default.
• W1990704706 cites W2133216840 @default.
• W1990704706 cites W2142609785 @default.
• W1990704706 cites W2144001627 @default.
• W1990704706 cites W2146401573 @default.
• W1990704706 cites W2155032388 @default.
• W1990704706 cites W2156363822 @default.
• W1990704706 cites W2158800467 @default.
• W1990704706 cites W2167525963 @default.
• W1990704706 cites W2179589581 @default.
• W1990704706 cites W2319534362 @default.
• W1990704706 cites W2414120197 @default.
• W1990704706 doi "https://doi.org/10.1016/j.yjmcc.2006.04.008" @default.
• W1990704706 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16750219" @default.
• W1990704706 hasPublicationYear "2006" @default.
• W1990704706 type Work @default.
• W1990704706 sameAs 1990704706 @default.
• W1990704706 citedByCount "16" @default.
• W1990704706 countsByYear W19907047062012 @default.
• W1990704706 countsByYear W19907047062013 @default.
• W1990704706 countsByYear W19907047062014 @default.
• W1990704706 countsByYear W19907047062015 @default.
• W1990704706 countsByYear W19907047062016 @default.
• W1990704706 countsByYear W19907047062017 @default.
• W1990704706 countsByYear W19907047062018 @default.
• W1990704706 crossrefType "journal-article" @default.
• W1990704706 hasAuthorship W1990704706A5013255314 @default.
• W1990704706 hasAuthorship W1990704706A5031817215 @default.
• W1990704706 hasAuthorship W1990704706A5034957704 @default.
• W1990704706 hasAuthorship W1990704706A5051781429 @default.
• W1990704706 hasAuthorship W1990704706A5055778361 @default.
• W1990704706 hasAuthorship W1990704706A5058492487 @default.
• W1990704706 hasAuthorship W1990704706A5088989762 @default.
• W1990704706 hasConcept C111566952 @default.
• W1990704706 hasConcept C126322002 @default.
• W1990704706 hasConcept C134018914 @default.
• W1990704706 hasConcept C170493617 @default.
• W1990704706 hasConcept C207200792 @default.
• W1990704706 hasConcept C2778198053 @default.
• W1990704706 hasConcept C2779178603 @default.
• W1990704706 hasConcept C3018686881 @default.
• W1990704706 hasConcept C71924100 @default.
• W1990704706 hasConcept C86803240 @default.
• W1990704706 hasConceptScore W1990704706C111566952 @default.
• W1990704706 hasConceptScore W1990704706C126322002 @default.
• W1990704706 hasConceptScore W1990704706C134018914 @default.

• next