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• W1990705309 abstract "The actions of wortmannin, an inhibitor of myosin light chain kinase (MLCK), on M‐type potassium current of dissociated bullfrog sympathetic neurones have been examined. The amplitude of M‐current was measured by whole cell recordings from cells pretreated with wortmannin (0.01–10 μ m ) or the wortmannin vehicle, dimethylsulphoxide (0.0001–0.1 vol%), for 30 min. Internal (recording pipette) solutions having three different pCa values (6, 7 and 8) were used for the measurements. Irrespective of the pCa, M‐current was not detectable when the cells were pretreated with 10 μ m wortmannin. Wortmannin, 3 μ m , produced 85–95% inhibition of the M‐current. Pretreatment with 10–30 n m wortmannin was without effect on M‐current. The M‐current inhibition by wortmannin at concentrations of 0.1–1 μ m depended on the pCa of the internal solution. Inhibition occurred only when the calcium‐rich (pCa = 6) internal solution was used. Pre‐treatment of the cells with wortmannin (10 μ m ) did not affect rapidly‐inactivating A‐type or delayed rectifier‐type potassium currents nor did it alter inwardly rectifying sodium‐potassium current ( I H ). These observations show that M‐current inhibition by wortmannin has two pharmacological profiles. One is calcium‐dependent and occurs at lower concentrations (0.1–1 μ m ), and is attributed to inhibition of MLCK by wortmannin. At higher concentrations (3–10 μ m ), wortmannin has an additional, calcium‐independent action, inhibiting the M‐current by an unknown mechanism." @default.
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• W1990705309 date "1995-01-01" @default.
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• W1990705309 title "Inhibition by wortmannin of M-current in bullfrog sympathetic neurones" @default.
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• W1990705309 doi "https://doi.org/10.1111/j.1476-5381.1995.tb13253.x" @default.
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