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- W1990711772 abstract "Although at the genetic level cancer is caused by diverse mutations, epigenetic modifications are characteristic of all cancers, from apparently normal precursor tissue to advanced metastatic disease, and these epigenetic modifications drive tumour cell heterogeneity. We propose a unifying model of cancer in which epigenetic dysregulation allows rapid selection for tumour cell survival at the expense of the host. Mechanisms involve both genetic mutations and epigenetic modifications that disrupt the function of genes that regulate the epigenome itself. Several exciting recent discoveries also point to a genome-scale disruption of the epigenome that involves large blocks of DNA hypomethylation, mutations of epigenetic modifier genes and alterations of heterochromatin in cancer (including large organized chromatin lysine modifications (LOCKs) and lamin-associated domains (LADs)), all of which increase epigenetic and gene expression plasticity. Our model suggests a new approach to cancer diagnosis and therapy that focuses on epigenetic dysregulation and has great potential for risk detection and chemoprevention." @default.
- W1990711772 created "2016-06-24" @default.
- W1990711772 creator A5046497102 @default.
- W1990711772 creator A5081156860 @default.
- W1990711772 date "2013-06-13" @default.
- W1990711772 modified "2023-10-14" @default.
- W1990711772 title "Cancer as a dysregulated epigenome allowing cellular growth advantage at the expense of the host" @default.
- W1990711772 cites W1504671101 @default.
- W1990711772 cites W1525070625 @default.
- W1990711772 cites W1595524418 @default.
- W1990711772 cites W1687968277 @default.
- W1990711772 cites W1760824447 @default.
- W1990711772 cites W1781296206 @default.
- W1990711772 cites W1963736125 @default.
- W1990711772 cites W1964563458 @default.
- W1990711772 cites W1966206981 @default.
- W1990711772 cites W1968391853 @default.
- W1990711772 cites W1969323007 @default.
- W1990711772 cites W1971319149 @default.
- W1990711772 cites W1971659434 @default.
- W1990711772 cites W1972049135 @default.
- W1990711772 cites W1973161736 @default.
- W1990711772 cites W1974359182 @default.
- W1990711772 cites W1974439810 @default.
- W1990711772 cites W1974459875 @default.
- W1990711772 cites W1974740818 @default.
- W1990711772 cites W1974747095 @default.
- W1990711772 cites W1974898805 @default.
- W1990711772 cites W1975141727 @default.
- W1990711772 cites W1978419388 @default.
- W1990711772 cites W1979855662 @default.
- W1990711772 cites W1979946545 @default.
- W1990711772 cites W1980194279 @default.
- W1990711772 cites W1980895750 @default.
- W1990711772 cites W1982865177 @default.
- W1990711772 cites W1984130135 @default.
- W1990711772 cites W1984562049 @default.
- W1990711772 cites W1984879354 @default.
- W1990711772 cites W1987561568 @default.
- W1990711772 cites W1989456683 @default.
- W1990711772 cites W1989773675 @default.
- W1990711772 cites W1989946661 @default.
- W1990711772 cites W1990557296 @default.
- W1990711772 cites W1992213480 @default.
- W1990711772 cites W1995070143 @default.
- W1990711772 cites W1996487270 @default.
- W1990711772 cites W2000305484 @default.
- W1990711772 cites W2002698073 @default.
- W1990711772 cites W2003262666 @default.
- W1990711772 cites W2003946492 @default.
- W1990711772 cites W2004063027 @default.
- W1990711772 cites W2005250386 @default.
- W1990711772 cites W2005725366 @default.
- W1990711772 cites W2008543992 @default.
- W1990711772 cites W2010399610 @default.
- W1990711772 cites W2010710786 @default.
- W1990711772 cites W2012509017 @default.
- W1990711772 cites W2013186220 @default.
- W1990711772 cites W2014432992 @default.
- W1990711772 cites W2016783733 @default.
- W1990711772 cites W2016849135 @default.
- W1990711772 cites W2016877107 @default.
- W1990711772 cites W2017308570 @default.
- W1990711772 cites W2017492512 @default.
- W1990711772 cites W2017840637 @default.
- W1990711772 cites W2019229253 @default.
- W1990711772 cites W2023568503 @default.
- W1990711772 cites W2024042273 @default.
- W1990711772 cites W2024109518 @default.
- W1990711772 cites W2024373518 @default.
- W1990711772 cites W2025021474 @default.
- W1990711772 cites W2029746613 @default.
- W1990711772 cites W2029940868 @default.
- W1990711772 cites W2034020712 @default.
- W1990711772 cites W2034852369 @default.
- W1990711772 cites W2037291224 @default.
- W1990711772 cites W2037548653 @default.
- W1990711772 cites W2038722690 @default.
- W1990711772 cites W2039408641 @default.
- W1990711772 cites W2041686632 @default.
- W1990711772 cites W2042087070 @default.
- W1990711772 cites W2042093631 @default.
- W1990711772 cites W2042386784 @default.
- W1990711772 cites W2044352858 @default.
- W1990711772 cites W2045184737 @default.
- W1990711772 cites W2050296716 @default.
- W1990711772 cites W2054051862 @default.
- W1990711772 cites W2054332862 @default.
- W1990711772 cites W2054444927 @default.
- W1990711772 cites W2054829361 @default.
- W1990711772 cites W2055327776 @default.
- W1990711772 cites W2058337538 @default.
- W1990711772 cites W2059024085 @default.
- W1990711772 cites W2059099579 @default.
- W1990711772 cites W2059587308 @default.
- W1990711772 cites W2059598057 @default.
- W1990711772 cites W2061891352 @default.
- W1990711772 cites W2062062519 @default.