FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1990717350> ?p ?o ?g. }

• W1990717350 endingPage "578" @default.
• W1990717350 startingPage "571" @default.
• W1990717350 abstract "Abstract Hyperosmotic solutions, of substances including polyvinylpyrrolidone, sodium or methylglucamine diatrizoate, sodium chloride, glucose, sucrose and mannitol, produced transient sinus bradycardia and a fall in arterial blood pressure when injected directly into the coronary arteries of the intact anesthetized dog. The same changes occurred with acute coronary venous hypertension induced by coronary sinus obstruction with a balloon catheter but not with injections of isosmotic saline solutions into the coronary artery or of the various substances into the aortic root, left ventricle or pulmonary artery. The bradycardia was prevented by atropine. Concomitant with the fall in blood pressure, femoral arterial blood flow increased and maximal rate of rise of left ventricular pressure ( dp dt ) decreased even when the bradycardia was prevented by pacing. In most experiments this reduction in maximal dp dt could be abolished by beta adrenergic blockade. All responses were abolished by bilateral vagotomy with the exception of the fall in pressure and maximal dp dt produced by the radiopaque media or 5 percent sodium chloride. These agents exert a direct myocardial depressant action. Simultaneously determined indicator-dilution curves using 125I-albumin and 131I-diatrizoate verified that the diatrizoate molecule leaves the circulation during its passage through the coronary vascular bed. Calculations derived from these curves demonstrated that injection of nonlabeled diatrizoate produces a large increase in coronary blood volume and flow. In 2 patients the bradycardia occurring with coronary injections of radiopaque media could be prevented by atropine. Sodium diatrizoate (50 percent Hypaque®) usually produced more intense bradycardia than did methylglucamine diatrizoate (60 percent Renografin®). The depressor effects of coronary injections of hyperosmotic solutions or coronary sinus obstruction result from activation of a reflex arc originating from stretch receptors in the coronary capillaries or small veins. The afferent limb of the reflex is bilaterally represented in the cervical vagosympathetic trunks of the dog. The efferent effects characterized in these experiments were increased vagal firing to the sinus node, decreased activity of adrenergic fibers to peripheral vascular alpha receptors and probably diminished adrenergic firing to beta receptors in the ventricular myocardium." @default.
• W1990717350 created "2016-06-24" @default.
• W1990717350 creator A5020002120 @default.
• W1990717350 creator A5057705844 @default.
• W1990717350 date "1970-05-01" @default.
• W1990717350 modified "2023-09-27" @default.
• W1990717350 title "Hemodynamic responses initiated by coronary stretch receptors with special reference to coronary arteriography" @default.
• W1990717350 cites W1978145105 @default.
• W1990717350 cites W2010769464 @default.
• W1990717350 cites W2029424309 @default.
• W1990717350 cites W2062118889 @default.
• W1990717350 cites W2070613084 @default.
• W1990717350 cites W2072491619 @default.
• W1990717350 cites W2075265053 @default.
• W1990717350 cites W2090827217 @default.
• W1990717350 cites W2092347853 @default.
• W1990717350 cites W2096468015 @default.
• W1990717350 cites W2109338186 @default.
• W1990717350 cites W2148900673 @default.
• W1990717350 cites W2153539288 @default.
• W1990717350 cites W2164738474 @default.
• W1990717350 cites W2172736073 @default.
• W1990717350 cites W2327019408 @default.
• W1990717350 cites W2327065050 @default.
• W1990717350 doi "https://doi.org/10.1016/0002-9149(70)90596-5" @default.
• W1990717350 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4245530" @default.
• W1990717350 hasPublicationYear "1970" @default.
• W1990717350 type Work @default.
• W1990717350 sameAs 1990717350 @default.
• W1990717350 citedByCount "44" @default.
• W1990717350 crossrefType "journal-article" @default.
• W1990717350 hasAuthorship W1990717350A5020002120 @default.
• W1990717350 hasAuthorship W1990717350A5057705844 @default.
• W1990717350 hasConcept C126322002 @default.
• W1990717350 hasConcept C158846371 @default.
• W1990717350 hasConcept C164705383 @default.
• W1990717350 hasConcept C178853913 @default.
• W1990717350 hasConcept C2776157398 @default.
• W1990717350 hasConcept C3019004856 @default.
• W1990717350 hasConcept C500558357 @default.
• W1990717350 hasConcept C71924100 @default.
• W1990717350 hasConceptScore W1990717350C126322002 @default.
• W1990717350 hasConceptScore W1990717350C158846371 @default.
• W1990717350 hasConceptScore W1990717350C164705383 @default.
• W1990717350 hasConceptScore W1990717350C178853913 @default.
• W1990717350 hasConceptScore W1990717350C2776157398 @default.
• W1990717350 hasConceptScore W1990717350C3019004856 @default.
• W1990717350 hasConceptScore W1990717350C500558357 @default.
• W1990717350 hasConceptScore W1990717350C71924100 @default.
• W1990717350 hasIssue "5" @default.
• W1990717350 hasLocation W19907173501 @default.
• W1990717350 hasLocation W19907173502 @default.
• W1990717350 hasOpenAccess W1990717350 @default.
• W1990717350 hasPrimaryLocation W19907173501 @default.
• W1990717350 hasRelatedWork W1978075485 @default.
• W1990717350 hasRelatedWork W2013137210 @default.
• W1990717350 hasRelatedWork W2017639841 @default.
• W1990717350 hasRelatedWork W2019232747 @default.
• W1990717350 hasRelatedWork W2092485796 @default.
• W1990717350 hasRelatedWork W2144528653 @default.
• W1990717350 hasRelatedWork W2387704921 @default.
• W1990717350 hasRelatedWork W307606819 @default.
• W1990717350 hasRelatedWork W32374484 @default.
• W1990717350 hasRelatedWork W6437325 @default.
• W1990717350 hasVolume "25" @default.
• W1990717350 isParatext "false" @default.
• W1990717350 isRetracted "false" @default.
• W1990717350 magId "1990717350" @default.
• W1990717350 workType "article" @default.