FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1990719986> ?p ?o ?g. }

• W1990719986 endingPage "e70074" @default.
• W1990719986 startingPage "e70074" @default.
• W1990719986 abstract "Evidence is increasing for involvement of the endocannabinoid system in cognitive functions including attention and executive function, as well as in psychiatric disorders characterized by cognitive deficits, such as schizophrenia. Executive function appears to be associated with both modulation of active networks and inhibition of activity in the default mode network. In the present study, we examined the role of the endocannabinoid system in executive function, focusing on both the associated brain network and the default mode network. A pharmacological functional magnetic resonance imaging (fMRI) study was conducted with a placebo-controlled, cross-over design, investigating effects of the endocannabinoid agonist Δ9-tetrahydrocannabinol (THC) on executive function in 20 healthy volunteers, using a continuous performance task with identical pairs. Task performance was impaired after THC administration, reflected in both an increase in false alarms and a reduction in detected targets. This was associated with reduced deactivation in a set of brain regions linked to the default mode network, including posterior cingulate cortex and angular gyrus. Less deactivation was significantly correlated with lower performance after THC. Regions that were activated by the continuous performance task, notably bilateral prefrontal and parietal cortex, did not show effects of THC. These findings suggest an important role for the endocannabinoid system in both default mode modulation and executive function. This may be relevant for psychiatric disorders associated with executive function deficits, such as schizophrenia and ADHD." @default.
• W1990719986 created "2016-06-24" @default.
• W1990719986 creator A5024201199 @default.
• W1990719986 creator A5031613969 @default.
• W1990719986 creator A5035670438 @default.
• W1990719986 creator A5052910579 @default.
• W1990719986 creator A5053813857 @default.
• W1990719986 creator A5063036619 @default.
• W1990719986 date "2013-07-31" @default.
• W1990719986 modified "2023-10-14" @default.
• W1990719986 title "Default Mode Network in the Effects of Δ9-Tetrahydrocannabinol (THC) on Human Executive Function" @default.
• W1990719986 cites W1919324175 @default.
• W1990719986 cites W1967825340 @default.
• W1990719986 cites W1972165745 @default.
• W1990719986 cites W197326298 @default.
• W1990719986 cites W1983208632 @default.
• W1990719986 cites W1987824932 @default.
• W1990719986 cites W1989297865 @default.
• W1990719986 cites W1990784243 @default.
• W1990719986 cites W1991694489 @default.
• W1990719986 cites W1997625719 @default.
• W1990719986 cites W1998148588 @default.
• W1990719986 cites W2005933475 @default.
• W1990719986 cites W2006503735 @default.
• W1990719986 cites W2011700455 @default.
• W1990719986 cites W2012090015 @default.
• W1990719986 cites W2012213317 @default.
• W1990719986 cites W2017543199 @default.
• W1990719986 cites W2017794961 @default.
• W1990719986 cites W2019370496 @default.
• W1990719986 cites W2021986306 @default.
• W1990719986 cites W2025177502 @default.
• W1990719986 cites W2025437677 @default.
• W1990719986 cites W2029386843 @default.
• W1990719986 cites W2041884326 @default.
• W1990719986 cites W2049946649 @default.
• W1990719986 cites W2053214223 @default.
• W1990719986 cites W2058014295 @default.
• W1990719986 cites W2059045968 @default.
• W1990719986 cites W2062908676 @default.
• W1990719986 cites W2070069429 @default.
• W1990719986 cites W2071695622 @default.
• W1990719986 cites W2075014983 @default.
• W1990719986 cites W2075128941 @default.
• W1990719986 cites W2081764100 @default.
• W1990719986 cites W2082787971 @default.
• W1990719986 cites W2096266931 @default.
• W1990719986 cites W2097636632 @default.
• W1990719986 cites W2099909319 @default.
• W1990719986 cites W2104016179 @default.
• W1990719986 cites W2112249501 @default.
• W1990719986 cites W2113307128 @default.
• W1990719986 cites W2113864940 @default.
• W1990719986 cites W2114788557 @default.
• W1990719986 cites W2115009729 @default.
• W1990719986 cites W2115687188 @default.
• W1990719986 cites W2116896023 @default.
• W1990719986 cites W2117207767 @default.
• W1990719986 cites W2119792333 @default.
• W1990719986 cites W2123187246 @default.
• W1990719986 cites W2123722617 @default.
• W1990719986 cites W2124470632 @default.
• W1990719986 cites W2131214643 @default.
• W1990719986 cites W2133144527 @default.
• W1990719986 cites W2136435696 @default.
• W1990719986 cites W2137746168 @default.
• W1990719986 cites W2144444435 @default.
• W1990719986 cites W2146561516 @default.
• W1990719986 cites W2148822665 @default.
• W1990719986 cites W2150323363 @default.
• W1990719986 cites W2156145226 @default.
• W1990719986 cites W2159594385 @default.
• W1990719986 cites W2162010696 @default.
• W1990719986 cites W2165151662 @default.
• W1990719986 cites W2168021161 @default.
• W1990719986 cites W2169605136 @default.
• W1990719986 cites W2170206898 @default.
• W1990719986 cites W2172031239 @default.
• W1990719986 doi "https://doi.org/10.1371/journal.pone.0070074" @default.
• W1990719986 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3729458" @default.
• W1990719986 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23936144" @default.
• W1990719986 hasPublicationYear "2013" @default.
• W1990719986 type Work @default.
• W1990719986 sameAs 1990719986 @default.
• W1990719986 citedByCount "53" @default.
• W1990719986 countsByYear W19907199862014 @default.
• W1990719986 countsByYear W19907199862015 @default.
• W1990719986 countsByYear W19907199862016 @default.
• W1990719986 countsByYear W19907199862017 @default.
• W1990719986 countsByYear W19907199862018 @default.
• W1990719986 countsByYear W19907199862019 @default.
• W1990719986 countsByYear W19907199862020 @default.
• W1990719986 countsByYear W19907199862021 @default.
• W1990719986 countsByYear W19907199862022 @default.
• W1990719986 countsByYear W19907199862023 @default.
• W1990719986 crossrefType "journal-article" @default.
• W1990719986 hasAuthorship W1990719986A5024201199 @default.
• W1990719986 hasAuthorship W1990719986A5031613969 @default.

• next