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- W1990722725 abstract "Our previous studies showed that ruthenium(II) polypyridyl complexes can suppress the proliferation of BEL-7402 and MG-63 cells. In the present study, two active complexes Ru-1 and Ru-2 were identified to effectively inhibit BEL-7402, HeLa, MCF-7 and MG-63 cells growth. The cytotoxicity in vitro of the complexes towards the above cell lines were evaluated by MTT assay. The IC50 values range from 5.1 to 18.5 μM. Complex Ru-2 shows higher cytotoxic activity than cisplatin towards selected cell lines under identical conditions. AO/EB and Hoechst 33258 staining and flow cytometry analyses indicate that Ru-1 and Ru-2 can induce apoptosis in BEL-7402 cells. In the assay of cell cycle arrest, Ru-2 can induce G0/G1 phase arrest on BEL-7402 cells. The two complexes can enhance the level of ROS and decrease the mitochondrial membrane potential. Ru-1 and Ru-2 induced apoptosis in BEL-7402 cells through the mitochondrial pathway. In addition, the DNA-binding of these complexes with calf thymus was also investigated." @default.
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- W1990722725 date "2013-08-01" @default.
- W1990722725 modified "2023-10-03" @default.
- W1990722725 title "DNA interaction, cytotoxicity, apoptotic activity, cell cycle arrest, reactive oxygen species and mitochondrial membrane potential assay induced by ruthenium(II) polypyridyl complexes" @default.
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- W1990722725 doi "https://doi.org/10.1016/j.ica.2013.06.002" @default.
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