FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1990735136> ?p ?o ?g. }

• W1990735136 endingPage "115" @default.
• W1990735136 startingPage "105" @default.
• W1990735136 abstract "Using a zymosan-induced mouse model of multiple organ dysfunction syndrome (MODS), we previously found profound increases in spleen immune cells’ expressions of ubiquitin and MHC-II molecules and increased CD11c+ dendritic cells (DCs) within 24 h of zymosan injection. We postulated that the early stage of MODS altered DCs function via an ubiquitination-associated mechanism. We intraperitoneally injected zymosan into 100 male C57BL/6 mice (0.8 mg/g) and randomly divided them into 5 groups based on the days after injection (20 mice/group): 1 d, 3 d, 5 d, 7 d, and 10 d. Mice were examined for spleen CD11c+ DC functions at the indicated days. Untreated mice were used for normal spleen tissue and T cell samples. By qPCR, IL-12 and TNF-α mRNA expressions in spleen CD11c+ DCs were significantly increased in MODS 1 d mice; on subsequent days post-injection, these mRNA levels gradually returned to control levels. The same patterns were found for MODS mice DCs induction of untreated mouse T cells proliferation and IL-2 and IFN-γ mRNA expressions. When T cell functions were examined using MODS 1 d DCs with and without MG132 treatment, an inhibitor of ubiquitinated protein degradation, T cell functional activities were enhanced by DCs treated with MG132. MODS 1 d DCs also had significantly reduced MARCH1 mRNA expression, a key ubiquitin ligase that regulates DCs MHC-II expression. Silencing DCs MARCH1 expression with siRNA resulted in enhancing their induction of T cell functional activities. Using co-immunoprecipitation, Western blot, and flow cytometry assays, we deduced that MARCH1 ubiquitinated DC surface MHC-II molecules to regulate DC's immune functions in MODS mice. Our results suggest that aberrant degradation of spleen DCs MARCH1-mediated ubiquitinated proteins is involved during the earliest stage of MODS development." @default.
• W1990735136 created "2016-06-24" @default.
• W1990735136 creator A5005228021 @default.
• W1990735136 creator A5019324040 @default.
• W1990735136 creator A5030336149 @default.
• W1990735136 creator A5046712043 @default.
• W1990735136 creator A5057186589 @default.
• W1990735136 date "2013-02-01" @default.
• W1990735136 modified "2023-10-18" @default.
• W1990735136 title "Altered MARCH1 ubiquination-regulated dendritic cell immune functions during the early stage of zymosan-induced multiple organ dysfunction syndrome (MODS) in mice" @default.
• W1990735136 cites W1507598785 @default.
• W1990735136 cites W1983869447 @default.
• W1990735136 cites W1993923133 @default.
• W1990735136 cites W1997875323 @default.
• W1990735136 cites W2010946325 @default.
• W1990735136 cites W2017556424 @default.
• W1990735136 cites W2020439035 @default.
• W1990735136 cites W2020795276 @default.
• W1990735136 cites W2020847425 @default.
• W1990735136 cites W2021308604 @default.
• W1990735136 cites W2025273503 @default.
• W1990735136 cites W2028191083 @default.
• W1990735136 cites W2032636734 @default.
• W1990735136 cites W2048190045 @default.
• W1990735136 cites W2068156832 @default.
• W1990735136 cites W2074428870 @default.
• W1990735136 cites W2075535797 @default.
• W1990735136 cites W2095751049 @default.
• W1990735136 cites W2104984927 @default.
• W1990735136 cites W2110678183 @default.
• W1990735136 cites W2112798365 @default.
• W1990735136 cites W2142424369 @default.
• W1990735136 cites W2143151869 @default.
• W1990735136 cites W2153503299 @default.
• W1990735136 cites W2157282632 @default.
• W1990735136 doi "https://doi.org/10.1016/j.imlet.2012.12.012" @default.
• W1990735136 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23305794" @default.
• W1990735136 hasPublicationYear "2013" @default.
• W1990735136 type Work @default.
• W1990735136 sameAs 1990735136 @default.
• W1990735136 citedByCount "9" @default.
• W1990735136 countsByYear W19907351362014 @default.
• W1990735136 countsByYear W19907351362016 @default.
• W1990735136 countsByYear W19907351362017 @default.
• W1990735136 countsByYear W19907351362018 @default.
• W1990735136 countsByYear W19907351362019 @default.
• W1990735136 countsByYear W19907351362021 @default.
• W1990735136 countsByYear W19907351362022 @default.
• W1990735136 crossrefType "journal-article" @default.
• W1990735136 hasAuthorship W1990735136A5005228021 @default.
• W1990735136 hasAuthorship W1990735136A5019324040 @default.
• W1990735136 hasAuthorship W1990735136A5030336149 @default.
• W1990735136 hasAuthorship W1990735136A5046712043 @default.
• W1990735136 hasAuthorship W1990735136A5057186589 @default.
• W1990735136 hasConcept C104317684 @default.
• W1990735136 hasConcept C127716648 @default.
• W1990735136 hasConcept C153911025 @default.
• W1990735136 hasConcept C189976730 @default.
• W1990735136 hasConcept C202751555 @default.
• W1990735136 hasConcept C203014093 @default.
• W1990735136 hasConcept C2776090121 @default.
• W1990735136 hasConcept C2776415932 @default.
• W1990735136 hasConcept C2778170410 @default.
• W1990735136 hasConcept C2778870864 @default.
• W1990735136 hasConcept C2779919695 @default.
• W1990735136 hasConcept C2780931953 @default.
• W1990735136 hasConcept C553184892 @default.
• W1990735136 hasConcept C55493867 @default.
• W1990735136 hasConcept C86803240 @default.
• W1990735136 hasConcept C8891405 @default.
• W1990735136 hasConceptScore W1990735136C104317684 @default.
• W1990735136 hasConceptScore W1990735136C127716648 @default.
• W1990735136 hasConceptScore W1990735136C153911025 @default.
• W1990735136 hasConceptScore W1990735136C189976730 @default.
• W1990735136 hasConceptScore W1990735136C202751555 @default.
• W1990735136 hasConceptScore W1990735136C203014093 @default.
• W1990735136 hasConceptScore W1990735136C2776090121 @default.
• W1990735136 hasConceptScore W1990735136C2776415932 @default.
• W1990735136 hasConceptScore W1990735136C2778170410 @default.
• W1990735136 hasConceptScore W1990735136C2778870864 @default.
• W1990735136 hasConceptScore W1990735136C2779919695 @default.
• W1990735136 hasConceptScore W1990735136C2780931953 @default.
• W1990735136 hasConceptScore W1990735136C553184892 @default.
• W1990735136 hasConceptScore W1990735136C55493867 @default.
• W1990735136 hasConceptScore W1990735136C86803240 @default.
• W1990735136 hasConceptScore W1990735136C8891405 @default.
• W1990735136 hasIssue "1-2" @default.
• W1990735136 hasLocation W19907351361 @default.
• W1990735136 hasLocation W19907351362 @default.
• W1990735136 hasOpenAccess W1990735136 @default.
• W1990735136 hasPrimaryLocation W19907351361 @default.
• W1990735136 hasRelatedWork W1544549699 @default.
• W1990735136 hasRelatedWork W2006139140 @default.
• W1990735136 hasRelatedWork W2081358646 @default.
• W1990735136 hasRelatedWork W2355513153 @default.
• W1990735136 hasRelatedWork W2363657934 @default.
• W1990735136 hasRelatedWork W2410219836 @default.
• W1990735136 hasRelatedWork W2419541480 @default.

• next