FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1990753699> ?p ?o ?g. }

• W1990753699 endingPage "1721" @default.
• W1990753699 startingPage "1708" @default.
• W1990753699 abstract "At least 10 enteroendocrine cell types have been identified, and the peptide hormones they secrete have diverse functions that include regulation of glucose homeostasis, food intake, and gastric emptying. Mice lacking individual enteroendocrine hormones, their receptors, or combinations of these have shed light on the role of these hormones in the regulation of energy homeostasis. However, because enteroendocrine hormones have partially overlapping functions, these loss-of-function studies produced only minor phenotypes, and none of the enteroendocrine hormones was shown to be essential for life. To examine the effect of loss of all enteroendocrine cells and hormones on energy homeostasis, we generated mice with intestinal-specific ablation of the proendocrine transcription factor neurogenin 3 (referred to herein as Ngn3Δint mice). Ngn3Δint mice were deficient for all enteroendocrine cells and hormones, and died with a high frequency during the first week of life. Mutant mice were growth retarded and had yellowish stool suggestive of steatorrhea. Subsequent analyses revealed that Ngn3Δint mice had impaired lipid absorption, reduced weight gain, and improved glucose homeostasis. Furthermore, intestinal epithelium of the mutant mice showed an enlarged proliferative crypt compartment and accelerated cell turnover but no changes to goblet and Paneth cell numbers. Enterocytes had shorter microvilli, but the expression of the main brush border enzymes was unaffected. Our data help unravel the role of enteroendocrine cells and hormones in lipid absorption and maintenance of the intestinal epithelium." @default.
• W1990753699 created "2016-06-24" @default.
• W1990753699 creator A5002123915 @default.
• W1990753699 creator A5038949948 @default.
• W1990753699 creator A5042936779 @default.
• W1990753699 creator A5046620580 @default.
• W1990753699 creator A5049656203 @default.
• W1990753699 creator A5055333789 @default.
• W1990753699 creator A5073374992 @default.
• W1990753699 date "2010-05-03" @default.
• W1990753699 modified "2023-10-10" @default.
• W1990753699 title "Loss of enteroendocrine cells in mice alters lipid absorption and glucose homeostasis and impairs postnatal survival" @default.
• W1990753699 cites W1591006241 @default.
• W1990753699 cites W180781382 @default.
• W1990753699 cites W1973489602 @default.
• W1990753699 cites W1974248149 @default.
• W1990753699 cites W1975234567 @default.
• W1990753699 cites W1987706317 @default.
• W1990753699 cites W1992588813 @default.
• W1990753699 cites W1992611765 @default.
• W1990753699 cites W2002907969 @default.
• W1990753699 cites W2003246207 @default.
• W1990753699 cites W2013395086 @default.
• W1990753699 cites W2032322539 @default.
• W1990753699 cites W2042082068 @default.
• W1990753699 cites W2043880988 @default.
• W1990753699 cites W2048371631 @default.
• W1990753699 cites W2050610306 @default.
• W1990753699 cites W2064034347 @default.
• W1990753699 cites W2065818402 @default.
• W1990753699 cites W2071450296 @default.
• W1990753699 cites W2078060668 @default.
• W1990753699 cites W2078810890 @default.
• W1990753699 cites W2081471404 @default.
• W1990753699 cites W2081666098 @default.
• W1990753699 cites W2083684207 @default.
• W1990753699 cites W2086329782 @default.
• W1990753699 cites W2096444181 @default.
• W1990753699 cites W2103750856 @default.
• W1990753699 cites W2107076497 @default.
• W1990753699 cites W2109517949 @default.
• W1990753699 cites W2114466471 @default.
• W1990753699 cites W2114695967 @default.
• W1990753699 cites W2118158977 @default.
• W1990753699 cites W2130236764 @default.
• W1990753699 cites W2130420663 @default.
• W1990753699 cites W2137987484 @default.
• W1990753699 cites W2142486892 @default.
• W1990753699 cites W2150013759 @default.
• W1990753699 cites W2154640315 @default.
• W1990753699 cites W2160216824 @default.
• W1990753699 cites W2160400743 @default.
• W1990753699 cites W2160940672 @default.
• W1990753699 cites W2169745228 @default.
• W1990753699 cites W2171779326 @default.
• W1990753699 cites W4233509207 @default.
• W1990753699 doi "https://doi.org/10.1172/jci40794" @default.
• W1990753699 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2860910" @default.
• W1990753699 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20364088" @default.
• W1990753699 hasPublicationYear "2010" @default.
• W1990753699 type Work @default.
• W1990753699 sameAs 1990753699 @default.
• W1990753699 citedByCount "81" @default.
• W1990753699 countsByYear W19907536992012 @default.
• W1990753699 countsByYear W19907536992013 @default.
• W1990753699 countsByYear W19907536992014 @default.
• W1990753699 countsByYear W19907536992015 @default.
• W1990753699 countsByYear W19907536992016 @default.
• W1990753699 countsByYear W19907536992017 @default.
• W1990753699 countsByYear W19907536992018 @default.
• W1990753699 countsByYear W19907536992019 @default.
• W1990753699 countsByYear W19907536992020 @default.
• W1990753699 countsByYear W19907536992021 @default.
• W1990753699 countsByYear W19907536992022 @default.
• W1990753699 countsByYear W19907536992023 @default.
• W1990753699 crossrefType "journal-article" @default.
• W1990753699 hasAuthorship W1990753699A5002123915 @default.
• W1990753699 hasAuthorship W1990753699A5038949948 @default.
• W1990753699 hasAuthorship W1990753699A5042936779 @default.
• W1990753699 hasAuthorship W1990753699A5046620580 @default.
• W1990753699 hasAuthorship W1990753699A5049656203 @default.
• W1990753699 hasAuthorship W1990753699A5055333789 @default.
• W1990753699 hasAuthorship W1990753699A5073374992 @default.
• W1990753699 hasBestOaLocation W19907536991 @default.
• W1990753699 hasConcept C103395026 @default.
• W1990753699 hasConcept C126322002 @default.
• W1990753699 hasConcept C134018914 @default.
• W1990753699 hasConcept C2491326 @default.
• W1990753699 hasConcept C2777391703 @default.
• W1990753699 hasConcept C2779306644 @default.
• W1990753699 hasConcept C2781077229 @default.
• W1990753699 hasConcept C3018667095 @default.
• W1990753699 hasConcept C46699223 @default.
• W1990753699 hasConcept C511355011 @default.
• W1990753699 hasConcept C529295009 @default.
• W1990753699 hasConcept C54355233 @default.
• W1990753699 hasConcept C63645605 @default.
• W1990753699 hasConcept C71315377 @default.

• next