FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1990756979> ?p ?o ?g. }

• W1990756979 endingPage "786" @default.
• W1990756979 startingPage "779" @default.
• W1990756979 abstract "The aim of this study was to measure serum and mucosal antibody responses following intranasal administration of biodegradable poly( dl -lactide- co -glycolide) (PLGA) microspheres loaded with the CS3 colonization factor isolated from enterotoxigenic Escherichia coli (ETEC). The response was compared against that measured in mice similarly administered the native CS3 antigen and in mice co-administered, along with the CS3 antigen, a known mucosal adjuvant, the R192G mutant heat-labile enterotoxin (mLT). The integrity of the CS3 antigen released from the microspheres was maintained as determined by SDS-PAGE and immunoblotting. Native CS3 induced serum and mucosal (bronchoalveolar, small intestinal and faecal) IgG and IgA responses. The co-administration of the mLT mucosal adjuvant significantly enhanced ( P <0·001) serum and mucosal antibody responses to the CS3 protein. Likewise, the CS3-loaded PLGA microspheres induced significantly greater ( P <0·001) serum and mucosal antibody responses than native CS3, as well as inducing antibody responses superior to those of the CS3 plus mLT formulation. Following administration of CS3 plus mLT, the mice became distressed (loss of activity, increased huddling, ruffled fur), a situation not seen following administration of the CS3-loaded PLGA microspheres. The results in this trial show that the CS3-loaded PLGA microspheres when administered intranasally to mice caused no observable distress to the mice and significantly ( P <0·001) enhanced the immunogenicity of the CS3 protein." @default.
• W1990756979 created "2016-06-24" @default.
• W1990756979 creator A5015560869 @default.
• W1990756979 creator A5020865600 @default.
• W1990756979 date "2006-03-01" @default.
• W1990756979 modified "2023-09-23" @default.
• W1990756979 title "The encapsulation of enterotoxigenic Escherichia coli colonization factor CS3 in biodegradable microspheres enhances the murine antibody response following intranasal administration" @default.
• W1990756979 cites W1515385862 @default.
• W1990756979 cites W1896912566 @default.
• W1990756979 cites W1918084043 @default.
• W1990756979 cites W1966371104 @default.
• W1990756979 cites W1972542038 @default.
• W1990756979 cites W1974972571 @default.
• W1990756979 cites W1992497253 @default.
• W1990756979 cites W1995250616 @default.
• W1990756979 cites W1996795202 @default.
• W1990756979 cites W2005006373 @default.
• W1990756979 cites W2007338930 @default.
• W1990756979 cites W2031341928 @default.
• W1990756979 cites W2032266561 @default.
• W1990756979 cites W2032362367 @default.
• W1990756979 cites W2037829353 @default.
• W1990756979 cites W2045162877 @default.
• W1990756979 cites W2060902946 @default.
• W1990756979 cites W2067734332 @default.
• W1990756979 cites W2079481424 @default.
• W1990756979 cites W2085520026 @default.
• W1990756979 cites W2087809796 @default.
• W1990756979 cites W2108838669 @default.
• W1990756979 cites W2116058470 @default.
• W1990756979 cites W2116974603 @default.
• W1990756979 cites W2121004847 @default.
• W1990756979 cites W2136060598 @default.
• W1990756979 cites W2148784430 @default.
• W1990756979 cites W2151164451 @default.
• W1990756979 cites W2154062809 @default.
• W1990756979 cites W2160105482 @default.
• W1990756979 cites W2163204755 @default.
• W1990756979 cites W2166865057 @default.
• W1990756979 cites W2465170492 @default.
• W1990756979 cites W4244703977 @default.
• W1990756979 cites W87088182 @default.
• W1990756979 doi "https://doi.org/10.1099/mic.0.28667-0" @default.
• W1990756979 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16514157" @default.
• W1990756979 hasPublicationYear "2006" @default.
• W1990756979 type Work @default.
• W1990756979 sameAs 1990756979 @default.
• W1990756979 citedByCount "6" @default.
• W1990756979 countsByYear W19907569792012 @default.
• W1990756979 countsByYear W19907569792013 @default.
• W1990756979 countsByYear W19907569792014 @default.
• W1990756979 crossrefType "journal-article" @default.
• W1990756979 hasAuthorship W1990756979A5015560869 @default.
• W1990756979 hasAuthorship W1990756979A5020865600 @default.
• W1990756979 hasConcept C104317684 @default.
• W1990756979 hasConcept C147483822 @default.
• W1990756979 hasConcept C159654299 @default.
• W1990756979 hasConcept C185592680 @default.
• W1990756979 hasConcept C202751555 @default.
• W1990756979 hasConcept C203014093 @default.
• W1990756979 hasConcept C2777863537 @default.
• W1990756979 hasConcept C2778353597 @default.
• W1990756979 hasConcept C2780165375 @default.
• W1990756979 hasConcept C2780868878 @default.
• W1990756979 hasConcept C547475151 @default.
• W1990756979 hasConcept C55493867 @default.
• W1990756979 hasConcept C66999527 @default.
• W1990756979 hasConcept C71924100 @default.
• W1990756979 hasConcept C85663871 @default.
• W1990756979 hasConcept C86803240 @default.
• W1990756979 hasConcept C89423630 @default.
• W1990756979 hasConcept C98274493 @default.
• W1990756979 hasConceptScore W1990756979C104317684 @default.
• W1990756979 hasConceptScore W1990756979C147483822 @default.
• W1990756979 hasConceptScore W1990756979C159654299 @default.
• W1990756979 hasConceptScore W1990756979C185592680 @default.
• W1990756979 hasConceptScore W1990756979C202751555 @default.
• W1990756979 hasConceptScore W1990756979C203014093 @default.
• W1990756979 hasConceptScore W1990756979C2777863537 @default.
• W1990756979 hasConceptScore W1990756979C2778353597 @default.
• W1990756979 hasConceptScore W1990756979C2780165375 @default.
• W1990756979 hasConceptScore W1990756979C2780868878 @default.
• W1990756979 hasConceptScore W1990756979C547475151 @default.
• W1990756979 hasConceptScore W1990756979C55493867 @default.
• W1990756979 hasConceptScore W1990756979C66999527 @default.
• W1990756979 hasConceptScore W1990756979C71924100 @default.
• W1990756979 hasConceptScore W1990756979C85663871 @default.
• W1990756979 hasConceptScore W1990756979C86803240 @default.
• W1990756979 hasConceptScore W1990756979C89423630 @default.
• W1990756979 hasConceptScore W1990756979C98274493 @default.
• W1990756979 hasIssue "3" @default.
• W1990756979 hasLocation W19907569791 @default.
• W1990756979 hasLocation W19907569792 @default.
• W1990756979 hasOpenAccess W1990756979 @default.
• W1990756979 hasPrimaryLocation W19907569791 @default.
• W1990756979 hasRelatedWork W1587527116 @default.
• W1990756979 hasRelatedWork W1973253116 @default.
• W1990756979 hasRelatedWork W1979439802 @default.

• next