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• W1990770039 abstract "In recent years two different styles of model for homologous recombination have been discussed, depending on whether or not the recombination event occurs in the vicinity of a double-strand break in DNA. The models of Holliday and Meselson and Radding exemplify those that do not involve a break whereas the model of Szostak et al is taken as an example of those that do. Recent advances in understanding a prototypic recombination system thought to promote exchange distant from DNA ends, at Chi sites, suggest a mechanism of initiation neither like Holliday/Meselson-Radding nor like Szostak et al. In those models, only one strand of DNA may invade a homologous DNA molecule. We propose a model for Chi in which exonuclease degrades DNA from a double-strand break to the Chi site; the exonuclease is converted into a helicase upon interaction with Chi; unwinding produces a recombinagenic split-end, and both 3'- and 5'-ending strands at the split-end are capable of invading a homologue. Different genetic consequences are proposed to result from invasion by each. We review evidence supporting the split-end model and suggest its application in at least some cases previously considered to proceed via the Meselson/Radding model and by the double-strand-break repair model of Szostak et al." @default.
• W1990770039 created "2016-06-24" @default.
• W1990770039 creator A5026001356 @default.
• W1990770039 creator A5068732023 @default.
• W1990770039 date "1991-04-01" @default.
• W1990770039 modified "2023-10-18" @default.
• W1990770039 title "The split-end model for homologous recombination at double-strand breaks and at Chi" @default.
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• W1990770039 doi "https://doi.org/10.1016/0300-9084(91)90105-a" @default.
• W1990770039 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1911939" @default.
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