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• W1990770317 abstract "It is considered axiomatic by those pursuing better health outcomes that well defined goals and clear timelines are essential to orderly progress. Many attribute to Florence Nightingale (1820–1910) leadership in creating the beginnings of management science by calling for accurate measurement applied to healthcare decision making in the 19th century. This guiding principle recognized in the earlier quotation from Galileo finds a modern counterpart in the Millennium Development Goals (MDG), the focus of this editorial [1]. With important implications for child health, the United Nations Millennium Summit, in 2000, advanced a set of eight development goals and targets intended to create a partnership between developed and developing countries with the aim of eliminating poverty and encouraging economic and social development [1]. Specific reductions in infant/child and maternal mortality were also targeted. The resulting campaign that began at the turn of the century has been endorsed by UN member states presently numbering 193 and by at least 23 international organizations representing civil society [2]. Why is this important to the readers of Pediatric Drugs? The achievement of optimal drug therapy, while not explicitly described, is clearly an element central to the main thrust of the Millennium Campaign. Goal 4, reduce child mortality; Goal 5, improve maternal health; and Goal 6, combat HIV/AIDS, malaria and other diseases [2, 3] are all reliant to some extent on achievement of consistent therapeutic excellence if ambitious targets for reduced morbidity and mortality are to be met. MDG 4 targets a reduction by two-thirds in the 1990 under-5 mortality rate (U5MR) by July 1, 2015. In addition, Goal 8 calls for new partnerships in development, including Target 8e, establishment of cooperative programs with pharmaceutical companies to provide access to affordable drugs in developing countries [3]. Evidence-informed therapy provides an essential foundation for the entire range of preventive and curative interventions in maternal and child health. Reductions in infant and child morbidity and mortality rely on improved nutrition and sanitation coupled with effectively deployed and equitably accessible therapies, including especially those targeting common conditions: micronutrients including trace minerals such as zinc, vitamins, vaccines, antimalarials and antimicrobials. The extent of shortfalls globally in provision of priority medicines for maternal and child health has recently been highlighted [4]. As a key component of the Millennium Campaign, more research about effects and disposition of medicines in the maturing infant and child is also needed. This has partly been accomplished in recent years by facilitation of pediatric clinical trials thanks to regulatory measures in the United States and in the European Union, but also as a result of a more positive attitude to research in children. Children have the same rights as adults to have access to therapies with drugs that are well documented in their own age groups. Although most progress in pediatric pharmacology has been made in developed countries, the clinical results will be applied in future for the benefit of children S. MacLeod (&) Child & Family Research Institute, BC Children’s Hospital, 950 West 28th Ave, Vancouver, BC V5Z 4H4, Canada e-mail: smacleod@cfri.ca" @default.
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• W1990770317 date "2014-03-05" @default.
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• W1990770317 title "Seeking Improved Global Child Health: Progress Toward Millennium Development Goal 4" @default.
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• W1990770317 doi "https://doi.org/10.1007/s40272-014-0068-2" @default.
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