FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1990802307> ?p ?o ?g. }

• W1990802307 endingPage "5724" @default.
• W1990802307 startingPage "5718" @default.
• W1990802307 abstract "It has been recently recognized that a distinct signaling pathway in the hypothalamus is involved in the stimulation of feeding in mammals. Neuropeptide Y (NPY), a member of the pancreatic polypeptide family, is the most potent orexigenic signal, and its secretion in discrete hypothalamic sites increases in response to insulinopenia produced by food deprivation or experimental diabetes. To establish the site of interaction between the hypothalamus and the pancreas, we examined the effects of insulin on NPY release in vivo and in vitro from hypothalamic sites known to be involved in feeding behavior. In the first study we evaluated the effects of peripheral insulin injections (1 U/kg.day, sc) on NPY levels in seven hypothalamic nuclei in food-deprived (FD) and ad libitum-fed rats. Whereas food deprivation for 3 days increased NPY levels in the medial preoptic area, paraventricular nucleus (PVN), and arcuate nucleus, insulin injections, which did not alter blood glucose levels, returned NPY levels to the control range selectively in the PVN. NPY levels in the hypothalamic nuclei remained unchanged after insulin injections in ad libitum-fed rats. The in vivo NPY release in the PVN of FD rats, evaluated by the push-pull cannula technique, also decreased in response to peripheral insulin injections. Finally, the effects of insulin, insulin-like growth factor I (IGF-I), and IGF-II on NPY release in vitro from the microdissected PVN and two central neighboring sites, the ventromedial nucleus and the median eminence-arcuate nucleus, of FD rats were evaluated. Both insulin (0.67 or 6.7 nM) and IGF-II (0.7 or 7.0 nM) decreased the release of NPY in a dose-dependent manner only from the PVN. On the other hand, IGF-I (0.07 or 7.0 nM) failed to alter the basal PVN NPY efflux. As the PVN is richly innervated by NPY-containing nerve terminals, the results of these in vivo and in vitro studies suggest that the site of insulin action on the hypothalamic NPY network may reside at the level of PVN nerve terminals or at the interneurons in contact with NPY nerve terminals. Although insulin may have a direct effect in reducing NPY release from the PVN, the effectiveness of IGF-II in decreasing NPY release from the PVN raises the possibility that insulin's action may also be mediated via hypothalamic IGF-II neuronal pathways." @default.
• W1990802307 created "2016-06-24" @default.
• W1990802307 creator A5028444807 @default.
• W1990802307 creator A5031672651 @default.
• W1990802307 creator A5031709252 @default.
• W1990802307 creator A5047037088 @default.
• W1990802307 creator A5061317637 @default.
• W1990802307 creator A5084980664 @default.
• W1990802307 date "1995-12-01" @default.
• W1990802307 modified "2023-09-23" @default.
• W1990802307 title "Insulin and insulin-like growth factor II suppress neuropeptide Y release from the nerve terminals in the paraventricular nucleus: a putative hypothalamic site for energy homeostasis." @default.
• W1990802307 cites W1510647987 @default.
• W1990802307 cites W1967708672 @default.
• W1990802307 cites W1970460118 @default.
• W1990802307 cites W1971911315 @default.
• W1990802307 cites W1972463082 @default.
• W1990802307 cites W1974885644 @default.
• W1990802307 cites W1976136395 @default.
• W1990802307 cites W1980335383 @default.
• W1990802307 cites W1982974700 @default.
• W1990802307 cites W1987811569 @default.
• W1990802307 cites W1988057141 @default.
• W1990802307 cites W1994217451 @default.
• W1990802307 cites W2002606463 @default.
• W1990802307 cites W2004286315 @default.
• W1990802307 cites W2023224640 @default.
• W1990802307 cites W2027710141 @default.
• W1990802307 cites W2030366306 @default.
• W1990802307 cites W2030893161 @default.
• W1990802307 cites W2031463222 @default.
• W1990802307 cites W2041315809 @default.
• W1990802307 cites W2042604118 @default.
• W1990802307 cites W2043267062 @default.
• W1990802307 cites W2047780911 @default.
• W1990802307 cites W2056954967 @default.
• W1990802307 cites W2075405314 @default.
• W1990802307 cites W2082106889 @default.
• W1990802307 cites W2083613579 @default.
• W1990802307 cites W2085086389 @default.
• W1990802307 cites W2085136188 @default.
• W1990802307 cites W2088777766 @default.
• W1990802307 cites W2090198261 @default.
• W1990802307 cites W2093749424 @default.
• W1990802307 cites W2097378006 @default.
• W1990802307 cites W2119509804 @default.
• W1990802307 cites W2128635872 @default.
• W1990802307 cites W2163815564 @default.
• W1990802307 cites W654694389 @default.
• W1990802307 doi "https://doi.org/10.1210/endo.136.12.7588328" @default.
• W1990802307 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7588328" @default.
• W1990802307 hasPublicationYear "1995" @default.
• W1990802307 type Work @default.
• W1990802307 sameAs 1990802307 @default.
• W1990802307 citedByCount "62" @default.
• W1990802307 countsByYear W19908023072013 @default.
• W1990802307 countsByYear W19908023072016 @default.
• W1990802307 countsByYear W19908023072017 @default.
• W1990802307 countsByYear W19908023072019 @default.
• W1990802307 countsByYear W19908023072020 @default.
• W1990802307 countsByYear W19908023072021 @default.
• W1990802307 crossrefType "journal-article" @default.
• W1990802307 hasAuthorship W1990802307A5028444807 @default.
• W1990802307 hasAuthorship W1990802307A5031672651 @default.
• W1990802307 hasAuthorship W1990802307A5031709252 @default.
• W1990802307 hasAuthorship W1990802307A5047037088 @default.
• W1990802307 hasAuthorship W1990802307A5061317637 @default.
• W1990802307 hasAuthorship W1990802307A5084980664 @default.
• W1990802307 hasConcept C118303440 @default.
• W1990802307 hasConcept C126322002 @default.
• W1990802307 hasConcept C134018914 @default.
• W1990802307 hasConcept C170493617 @default.
• W1990802307 hasConcept C185592680 @default.
• W1990802307 hasConcept C2777003273 @default.
• W1990802307 hasConcept C2777205416 @default.
• W1990802307 hasConcept C2778458369 @default.
• W1990802307 hasConcept C2779067335 @default.
• W1990802307 hasConcept C2779306644 @default.
• W1990802307 hasConcept C71924100 @default.
• W1990802307 hasConcept C86803240 @default.
• W1990802307 hasConcept C93984277 @default.
• W1990802307 hasConceptScore W1990802307C118303440 @default.
• W1990802307 hasConceptScore W1990802307C126322002 @default.
• W1990802307 hasConceptScore W1990802307C134018914 @default.
• W1990802307 hasConceptScore W1990802307C170493617 @default.
• W1990802307 hasConceptScore W1990802307C185592680 @default.
• W1990802307 hasConceptScore W1990802307C2777003273 @default.
• W1990802307 hasConceptScore W1990802307C2777205416 @default.
• W1990802307 hasConceptScore W1990802307C2778458369 @default.
• W1990802307 hasConceptScore W1990802307C2779067335 @default.
• W1990802307 hasConceptScore W1990802307C2779306644 @default.
• W1990802307 hasConceptScore W1990802307C71924100 @default.
• W1990802307 hasConceptScore W1990802307C86803240 @default.
• W1990802307 hasConceptScore W1990802307C93984277 @default.
• W1990802307 hasIssue "12" @default.
• W1990802307 hasLocation W19908023071 @default.
• W1990802307 hasLocation W19908023072 @default.
• W1990802307 hasOpenAccess W1990802307 @default.
• W1990802307 hasPrimaryLocation W19908023071 @default.

• next