FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1990803471> ?p ?o ?g. }

• W1990803471 endingPage "1077" @default.
• W1990803471 startingPage "1070" @default.
• W1990803471 abstract "DNA-based vaccines, while highly immunogenic in mice, generate significantly weaker responses in primates. Therefore, current efforts are aimed at increasing their immunogenicity, which include optimizing the plasmid/gene, the vaccine formulation and method of delivery. For example, co-immunization with molecular adjuvants encoding an immunomodulatory protein has been shown to improve the antigen (Ag)-specific immune response. Thus, the incorporation of enhancing elements, such as these, may be particularly important in the influenza model in which high titered antibody (Ab) responses are critical for protection. In this regard, we compared the ability of plasmid-encoded high-mobility group box 1 protein (HMGB1), a novel cytokine in which we have previously mutated in order to increase DNA vaccine immunogenicity, with boost Ag-specific immune responses during DNA vaccination with influenza A/PR/8/34 nucleoprotein or the hemagglutinin of A novel H1N1/09. We show that the HMGB1 adjuvant is capable of enhancing adaptive effector and memory immune responses. Although Ag-specific antibodies were detected in all vaccinated animals, a greater neutralizing Ab response was associated with the HMGB1 adjuvant. Furthermore, these responses improved CD8 T+-cell effector and memory responses and provided protection against a lethal mucosal influenza A/PR/8/34 challenge. Thus, co-immunization with HMGB1 has strong in vivo adjuvant activity during the development of immunity against plasmid-encoded Ag." @default.
• W1990803471 created "2016-06-24" @default.
• W1990803471 creator A5001379625 @default.
• W1990803471 creator A5014392443 @default.
• W1990803471 creator A5018957190 @default.
• W1990803471 creator A5023265367 @default.
• W1990803471 creator A5038753752 @default.
• W1990803471 creator A5045028558 @default.
• W1990803471 creator A5049793176 @default.
• W1990803471 creator A5051596113 @default.
• W1990803471 creator A5051652706 @default.
• W1990803471 creator A5058008872 @default.
• W1990803471 creator A5074185619 @default.
• W1990803471 date "2011-05-05" @default.
• W1990803471 modified "2023-10-05" @default.
• W1990803471 title "Molecular adjuvant HMGB1 enhances anti-influenza immunity during DNA vaccination" @default.
• W1990803471 cites W1608238667 @default.
• W1990803471 cites W1967113821 @default.
• W1990803471 cites W1984511743 @default.
• W1990803471 cites W1998740008 @default.
• W1990803471 cites W2003012126 @default.
• W1990803471 cites W2008667095 @default.
• W1990803471 cites W2013355912 @default.
• W1990803471 cites W2019042773 @default.
• W1990803471 cites W2019313744 @default.
• W1990803471 cites W2036792929 @default.
• W1990803471 cites W2037629336 @default.
• W1990803471 cites W2039106301 @default.
• W1990803471 cites W2046142225 @default.
• W1990803471 cites W2046290067 @default.
• W1990803471 cites W2046391048 @default.
• W1990803471 cites W2050796469 @default.
• W1990803471 cites W2055364909 @default.
• W1990803471 cites W2056785205 @default.
• W1990803471 cites W2057901653 @default.
• W1990803471 cites W2065818546 @default.
• W1990803471 cites W2075365494 @default.
• W1990803471 cites W2076534074 @default.
• W1990803471 cites W2077966115 @default.
• W1990803471 cites W2078446518 @default.
• W1990803471 cites W2080393767 @default.
• W1990803471 cites W2081328426 @default.
• W1990803471 cites W2082323859 @default.
• W1990803471 cites W2089712328 @default.
• W1990803471 cites W2093284893 @default.
• W1990803471 cites W2094175565 @default.
• W1990803471 cites W2098558375 @default.
• W1990803471 cites W2141705346 @default.
• W1990803471 cites W2169704851 @default.
• W1990803471 doi "https://doi.org/10.1038/gt.2011.59" @default.
• W1990803471 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4141626" @default.
• W1990803471 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21544096" @default.
• W1990803471 hasPublicationYear "2011" @default.
• W1990803471 type Work @default.
• W1990803471 sameAs 1990803471 @default.
• W1990803471 citedByCount "45" @default.
• W1990803471 countsByYear W19908034712012 @default.
• W1990803471 countsByYear W19908034712013 @default.
• W1990803471 countsByYear W19908034712014 @default.
• W1990803471 countsByYear W19908034712015 @default.
• W1990803471 countsByYear W19908034712016 @default.
• W1990803471 countsByYear W19908034712017 @default.
• W1990803471 countsByYear W19908034712018 @default.
• W1990803471 countsByYear W19908034712020 @default.
• W1990803471 countsByYear W19908034712021 @default.
• W1990803471 countsByYear W19908034712022 @default.
• W1990803471 crossrefType "journal-article" @default.
• W1990803471 hasAuthorship W1990803471A5001379625 @default.
• W1990803471 hasAuthorship W1990803471A5014392443 @default.
• W1990803471 hasAuthorship W1990803471A5018957190 @default.
• W1990803471 hasAuthorship W1990803471A5023265367 @default.
• W1990803471 hasAuthorship W1990803471A5038753752 @default.
• W1990803471 hasAuthorship W1990803471A5045028558 @default.
• W1990803471 hasAuthorship W1990803471A5049793176 @default.
• W1990803471 hasAuthorship W1990803471A5051596113 @default.
• W1990803471 hasAuthorship W1990803471A5051652706 @default.
• W1990803471 hasAuthorship W1990803471A5058008872 @default.
• W1990803471 hasAuthorship W1990803471A5074185619 @default.
• W1990803471 hasBestOaLocation W19908034711 @default.
• W1990803471 hasConcept C147483822 @default.
• W1990803471 hasConcept C159047783 @default.
• W1990803471 hasConcept C159654299 @default.
• W1990803471 hasConcept C167508917 @default.
• W1990803471 hasConcept C203014093 @default.
• W1990803471 hasConcept C22070199 @default.
• W1990803471 hasConcept C2522874641 @default.
• W1990803471 hasConcept C2776914184 @default.
• W1990803471 hasConcept C2777546802 @default.
• W1990803471 hasConcept C2777863537 @default.
• W1990803471 hasConcept C2778692840 @default.
• W1990803471 hasConcept C2779341262 @default.
• W1990803471 hasConcept C2780545709 @default.
• W1990803471 hasConcept C2780801004 @default.
• W1990803471 hasConcept C2780868878 @default.
• W1990803471 hasConcept C86803240 @default.
• W1990803471 hasConcept C8891405 @default.
• W1990803471 hasConceptScore W1990803471C147483822 @default.
• W1990803471 hasConceptScore W1990803471C159047783 @default.

• next