FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1990814887> ?p ?o ?g. }

• W1990814887 endingPage "E237" @default.
• W1990814887 startingPage "E233" @default.
• W1990814887 abstract "Accumulating evidence suggests that hyperactivity of the hypothalamic-pituitary-adrenal axis (HPA axis) is involved in depression. 11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) converts inert cortisone to active cortisol and is implicated in HPA axis regulation in animal studies. The aim of our study was to identify polymorphisms in 11β-HSD1 gene (HSD11B1) with consistent associations with increased HPA axis activity and relate those polymorphisms to depression. Twelve single-nucleotide polymorphisms (SNPs), including 11 tagging SNPs, were selected using the HapMap database and genotyped in 4228 participants of the population-based Rotterdam Study. The outcome measures were salivary cortisol levels after awakening, 30 min later, at 1700 h, at bedtime, and plasma levels of androstenedione (in women only). SNPs that were significantly associated with cortisol as well as androstenedione levels were also related to incident depression. rs11119328 was associated with higher cortisol saliva samples collected at bedtime as well as higher androstenedione levels (P value after correction for multiple testing: 0.01 and 0.04, respectively). Carriers of this polymorphism had an increased risk of an incident depression (hazard ratio 1.28, 95% confidence interval 1.03–1.59). Two other SNPs, which were in high linkage disequilibrium with rs11119328, were related to higher cortisol levels but not with androstenedione levels. We identified one SNP, which was associated with increased salivary cortisol levels at nadir as well as higher androstenedione levels. Moreover, this SNP was also associated with a higher risk of an incident depression. This suggests that 11β-HSD1 is implicated in human HPA axis regulation and susceptibility to depression." @default.
• W1990814887 created "2016-06-24" @default.
• W1990814887 creator A5012841131 @default.
• W1990814887 creator A5020686629 @default.
• W1990814887 creator A5037459627 @default.
• W1990814887 creator A5046911852 @default.
• W1990814887 creator A5050877182 @default.
• W1990814887 creator A5051737664 @default.
• W1990814887 creator A5052017533 @default.
• W1990814887 creator A5056878179 @default.
• W1990814887 creator A5087549185 @default.
• W1990814887 date "2012-02-01" @default.
• W1990814887 modified "2023-09-25" @default.
• W1990814887 title "The Effect of Common Genetic Variation in 11β-Hydroxysteroid Dehydrogenase Type 1 on Hypothalamic-Pituitary-Adrenal Axis Activity and Incident Depression" @default.
• W1990814887 cites W1968014809 @default.
• W1990814887 cites W1971472848 @default.
• W1990814887 cites W2009822274 @default.
• W1990814887 cites W2016125985 @default.
• W1990814887 cites W2032932933 @default.
• W1990814887 cites W2063231989 @default.
• W1990814887 cites W2070239192 @default.
• W1990814887 cites W2095224796 @default.
• W1990814887 cites W2136078375 @default.
• W1990814887 cites W2137714495 @default.
• W1990814887 cites W2161245845 @default.
• W1990814887 cites W2165340302 @default.
• W1990814887 cites W2172132445 @default.
• W1990814887 cites W4211231996 @default.
• W1990814887 doi "https://doi.org/10.1210/jc.2011-0601" @default.
• W1990814887 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22112815" @default.
• W1990814887 hasPublicationYear "2012" @default.
• W1990814887 type Work @default.
• W1990814887 sameAs 1990814887 @default.
• W1990814887 citedByCount "37" @default.
• W1990814887 countsByYear W19908148872012 @default.
• W1990814887 countsByYear W19908148872013 @default.
• W1990814887 countsByYear W19908148872014 @default.
• W1990814887 countsByYear W19908148872015 @default.
• W1990814887 countsByYear W19908148872016 @default.
• W1990814887 countsByYear W19908148872017 @default.
• W1990814887 countsByYear W19908148872018 @default.
• W1990814887 countsByYear W19908148872019 @default.
• W1990814887 countsByYear W19908148872020 @default.
• W1990814887 countsByYear W19908148872022 @default.
• W1990814887 crossrefType "journal-article" @default.
• W1990814887 hasAuthorship W1990814887A5012841131 @default.
• W1990814887 hasAuthorship W1990814887A5020686629 @default.
• W1990814887 hasAuthorship W1990814887A5037459627 @default.
• W1990814887 hasAuthorship W1990814887A5046911852 @default.
• W1990814887 hasAuthorship W1990814887A5050877182 @default.
• W1990814887 hasAuthorship W1990814887A5051737664 @default.
• W1990814887 hasAuthorship W1990814887A5052017533 @default.
• W1990814887 hasAuthorship W1990814887A5056878179 @default.
• W1990814887 hasAuthorship W1990814887A5087549185 @default.
• W1990814887 hasBestOaLocation W19908148871 @default.
• W1990814887 hasConcept C104317684 @default.
• W1990814887 hasConcept C126322002 @default.
• W1990814887 hasConcept C134018914 @default.
• W1990814887 hasConcept C135763542 @default.
• W1990814887 hasConcept C153209595 @default.
• W1990814887 hasConcept C2776683971 @default.
• W1990814887 hasConcept C2777911890 @default.
• W1990814887 hasConcept C2778709874 @default.
• W1990814887 hasConcept C2779146795 @default.
• W1990814887 hasConcept C2908647359 @default.
• W1990814887 hasConcept C54355233 @default.
• W1990814887 hasConcept C71315377 @default.
• W1990814887 hasConcept C71924100 @default.
• W1990814887 hasConcept C86803240 @default.
• W1990814887 hasConcept C99454951 @default.
• W1990814887 hasConceptScore W1990814887C104317684 @default.
• W1990814887 hasConceptScore W1990814887C126322002 @default.
• W1990814887 hasConceptScore W1990814887C134018914 @default.
• W1990814887 hasConceptScore W1990814887C135763542 @default.
• W1990814887 hasConceptScore W1990814887C153209595 @default.
• W1990814887 hasConceptScore W1990814887C2776683971 @default.
• W1990814887 hasConceptScore W1990814887C2777911890 @default.
• W1990814887 hasConceptScore W1990814887C2778709874 @default.
• W1990814887 hasConceptScore W1990814887C2779146795 @default.
• W1990814887 hasConceptScore W1990814887C2908647359 @default.
• W1990814887 hasConceptScore W1990814887C54355233 @default.
• W1990814887 hasConceptScore W1990814887C71315377 @default.
• W1990814887 hasConceptScore W1990814887C71924100 @default.
• W1990814887 hasConceptScore W1990814887C86803240 @default.
• W1990814887 hasConceptScore W1990814887C99454951 @default.
• W1990814887 hasIssue "2" @default.
• W1990814887 hasLocation W19908148871 @default.
• W1990814887 hasLocation W19908148872 @default.
• W1990814887 hasLocation W19908148873 @default.
• W1990814887 hasLocation W19908148874 @default.
• W1990814887 hasOpenAccess W1990814887 @default.
• W1990814887 hasPrimaryLocation W19908148871 @default.
• W1990814887 hasRelatedWork W2010054296 @default.
• W1990814887 hasRelatedWork W2041880296 @default.
• W1990814887 hasRelatedWork W2045808740 @default.
• W1990814887 hasRelatedWork W2052353851 @default.
• W1990814887 hasRelatedWork W2066590152 @default.
• W1990814887 hasRelatedWork W2071784968 @default.

• next