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Matches in SemOpenAlex for { <https://semopenalex.org/work/W199081716> ?p ?o ?g. }

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• W199081716 abstract "Diastereomeric arylcyclopropylamines substituted with fluorine in the 2-position and with electron donating or electron withdrawing groups at the aromatic ring were evaluated as inhibitors of microbial tyramine oxidase. The trans-isomers were consistently more potent inhibitors of the enzyme than the cis-isomers. Electron donating substituents increased the potency of tyramine oxidase inhibition, while electron withdrawing substituents decreased the activity. The results obtained are discussed in terms of pK(a) and log D values of the inhibitors as well as the mechanism of action of tranylcypromines and the geometry of the active site of the enzyme." @default.
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• W199081716 date "2008-09-01" @default.
• W199081716 modified "2023-10-12" @default.
• W199081716 title "Fluorinated phenylcyclopropylamines" @default.
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• W199081716 doi "https://doi.org/10.1016/j.jfluchem.2008.06.023" @default.
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