FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1990825306> ?p ?o ?g. }

• W1990825306 endingPage "304" @default.
• W1990825306 startingPage "296" @default.
• W1990825306 abstract "Previously, we reported that glycine N-methyltransferase (GNMT) knockout mice develop chronic hepatitis and hepatocellular carcinoma (HCC) spontaneously. For this study we used a phosphoenolpyruvate carboxykinase promoter to establish a GNMT transgenic (TG) mouse model. Animals were intraperitoneally inoculated with aflatoxin B1 (AFB1) and monitored for 11 months, during which neither male nor female GNMT-TG mice developed HCC. In contrast, 4 of 6 (67%) male wild-type mice developed HCC. Immunofluorescent antibody test showed that GNMT was translocated into nuclei after AFB1 treatment. Competitive enzyme immunoassays indicated that after AFB1 treatment, the AFB1–DNA adducts formed in stable clones expressing GNMT reduced 51.4% compared to the vector control clones. Experiments using recombinant adenoviruses carrying GNMT cDNA (Ad-GNMT) further demonstrated that the GNMT-related inhibition of AFB1–DNA adducts formation is dose-dependent. HPLC analysis of the metabolites of AFB1 in the cultural supernatants of cells exposed to AFB1 showed that the AFM1 level in the GNMT group was significantly higher than the control group, indicating the presence of GNMT can enhance the detoxification pathway of AFB1. Cytotoxicity assay showed that the GNMT group had higher survival rate than the control group after they were treated with AFB1. Automated docking experiments showed that AFB1 binds to the S-adenosylmethionine binding domain of GNMT. Affinity sensor assay demonstrated that the dissociation constant for GNMT–AFB1 interaction is 44.9 μM. Therefore, GNMT is a tumor suppressor for HCC and it exerts protective effects in hepatocytes via direct interaction with AFB1, resulting in reduced AFB1–DNA adducts formation and cell death." @default.
• W1990825306 created "2016-06-24" @default.
• W1990825306 creator A5013069037 @default.
• W1990825306 creator A5017274676 @default.
• W1990825306 creator A5042736471 @default.
• W1990825306 creator A5045495656 @default.
• W1990825306 creator A5049040142 @default.
• W1990825306 creator A5050492618 @default.
• W1990825306 creator A5061415617 @default.
• W1990825306 creator A5072245275 @default.
• W1990825306 creator A5074493882 @default.
• W1990825306 creator A5076847047 @default.
• W1990825306 creator A5088992624 @default.
• W1990825306 date "2009-03-01" @default.
• W1990825306 modified "2023-10-05" @default.
• W1990825306 title "Glycine N-methyltransferase affects the metabolism of aflatoxin B1 and blocks its carcinogenic effect" @default.
• W1990825306 cites W1512670651 @default.
• W1990825306 cites W1965826580 @default.
• W1990825306 cites W1970086110 @default.
• W1990825306 cites W1979107338 @default.
• W1990825306 cites W1983996384 @default.
• W1990825306 cites W1985418934 @default.
• W1990825306 cites W1990296956 @default.
• W1990825306 cites W1993375985 @default.
• W1990825306 cites W1994803330 @default.
• W1990825306 cites W1996201492 @default.
• W1990825306 cites W2001772619 @default.
• W1990825306 cites W2013502676 @default.
• W1990825306 cites W2020067236 @default.
• W1990825306 cites W2035794058 @default.
• W1990825306 cites W2036504837 @default.
• W1990825306 cites W2038108884 @default.
• W1990825306 cites W2042753075 @default.
• W1990825306 cites W2043554903 @default.
• W1990825306 cites W2047635278 @default.
• W1990825306 cites W2056209977 @default.
• W1990825306 cites W2071417758 @default.
• W1990825306 cites W2079213399 @default.
• W1990825306 cites W2083506021 @default.
• W1990825306 cites W2083842559 @default.
• W1990825306 cites W2089401171 @default.
• W1990825306 cites W2091658923 @default.
• W1990825306 cites W2094984629 @default.
• W1990825306 cites W2116030627 @default.
• W1990825306 cites W2116416121 @default.
• W1990825306 cites W2147731861 @default.
• W1990825306 cites W2153767651 @default.
• W1990825306 cites W2158534713 @default.
• W1990825306 cites W2160601806 @default.
• W1990825306 cites W2405173083 @default.
• W1990825306 doi "https://doi.org/10.1016/j.taap.2008.12.013" @default.
• W1990825306 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19146867" @default.
• W1990825306 hasPublicationYear "2009" @default.
• W1990825306 type Work @default.
• W1990825306 sameAs 1990825306 @default.
• W1990825306 citedByCount "34" @default.
• W1990825306 countsByYear W19908253062012 @default.
• W1990825306 countsByYear W19908253062013 @default.
• W1990825306 countsByYear W19908253062014 @default.
• W1990825306 countsByYear W19908253062015 @default.
• W1990825306 countsByYear W19908253062016 @default.
• W1990825306 countsByYear W19908253062017 @default.
• W1990825306 countsByYear W19908253062018 @default.
• W1990825306 countsByYear W19908253062019 @default.
• W1990825306 countsByYear W19908253062021 @default.
• W1990825306 countsByYear W19908253062022 @default.
• W1990825306 crossrefType "journal-article" @default.
• W1990825306 hasAuthorship W1990825306A5013069037 @default.
• W1990825306 hasAuthorship W1990825306A5017274676 @default.
• W1990825306 hasAuthorship W1990825306A5042736471 @default.
• W1990825306 hasAuthorship W1990825306A5045495656 @default.
• W1990825306 hasAuthorship W1990825306A5049040142 @default.
• W1990825306 hasAuthorship W1990825306A5050492618 @default.
• W1990825306 hasAuthorship W1990825306A5061415617 @default.
• W1990825306 hasAuthorship W1990825306A5072245275 @default.
• W1990825306 hasAuthorship W1990825306A5074493882 @default.
• W1990825306 hasAuthorship W1990825306A5076847047 @default.
• W1990825306 hasAuthorship W1990825306A5088992624 @default.
• W1990825306 hasConcept C114246631 @default.
• W1990825306 hasConcept C153911025 @default.
• W1990825306 hasConcept C185592680 @default.
• W1990825306 hasConcept C31903555 @default.
• W1990825306 hasConcept C40758303 @default.
• W1990825306 hasConcept C55493867 @default.
• W1990825306 hasConcept C86803240 @default.
• W1990825306 hasConceptScore W1990825306C114246631 @default.
• W1990825306 hasConceptScore W1990825306C153911025 @default.
• W1990825306 hasConceptScore W1990825306C185592680 @default.
• W1990825306 hasConceptScore W1990825306C31903555 @default.
• W1990825306 hasConceptScore W1990825306C40758303 @default.
• W1990825306 hasConceptScore W1990825306C55493867 @default.
• W1990825306 hasConceptScore W1990825306C86803240 @default.
• W1990825306 hasIssue "3" @default.
• W1990825306 hasLocation W19908253061 @default.
• W1990825306 hasLocation W19908253062 @default.
• W1990825306 hasOpenAccess W1990825306 @default.
• W1990825306 hasPrimaryLocation W19908253061 @default.
• W1990825306 hasRelatedWork W1868538441 @default.

• next