FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1990826306> ?p ?o ?g. }

• W1990826306 endingPage "2S59" @default.
• W1990826306 startingPage "2S52" @default.
• W1990826306 abstract "Infantile spasms usually start during the first year of life and constitute one of the most difficult types of epilepsy to treat. They carry a very poor prognosis for both epilepsy and mental development. Seventy children, including 47 infants, with intractable infantile spasms were entered into an open study with vigabatrin as add-on therapy to the usual anticonvulsant treatment. All were resistant to previous treatments, including corticosteroids (43 patients), carbamazepine, benzodiazepines, and sodium valproate. Two children withdrew from the study because of intolerance to vigabatrin (hypotonia or hypertonia) before evaluation of efficacy could be made. Of the remaining 68 children, 29 (43%) showed complete suppression of spasms. Forty-six children had a greater than 50% reduction in spasms. The best response was observed in those with tuberous sclerosis (12/14 compared with 12/18 with symptomatic infantile spasms of other origin and 22/36 with cryptogenic infantile spasms). Following the initial response to treatment of these patients (n = 68), a long-term response was confirmed in 75% of children with symptomatic infantile spasms and 36% of children with cryptogenic infantile spasms. In eight children, all other anticonvulsant medication could be definitively withdrawn. Tolerability appeared excellent, with 52 of 70 patients reporting no side effects. Somnolence, hypotonia, weight gain, excitation, and insomnia were the most common problems at the beginning of the study and were usually transient. Given the poor prognosis of this type of childhood epilepsy, vigabatrin appears to be a very interesting advance in the management of drug-resistant infantile spasms." @default.
• W1990826306 created "2016-06-24" @default.
• W1990826306 creator A5005910163 @default.
• W1990826306 creator A5040726455 @default.
• W1990826306 creator A5044265198 @default.
• W1990826306 creator A5046418848 @default.
• W1990826306 creator A5080857249 @default.
• W1990826306 creator A5084454925 @default.
• W1990826306 date "1991-10-01" @default.
• W1990826306 modified "2023-10-10" @default.
• W1990826306 title "Therapeutic Trial of Vigabatrin in Refractory Infantile Spasms" @default.
• W1990826306 cites W1517742863 @default.
• W1990826306 cites W1964011929 @default.
• W1990826306 cites W1986107939 @default.
• W1990826306 cites W1988657178 @default.
• W1990826306 cites W1990174203 @default.
• W1990826306 cites W1994735175 @default.
• W1990826306 cites W2013906440 @default.
• W1990826306 cites W2022755620 @default.
• W1990826306 cites W2031723474 @default.
• W1990826306 cites W2035058621 @default.
• W1990826306 cites W2035562497 @default.
• W1990826306 cites W2037604208 @default.
• W1990826306 cites W2041447261 @default.
• W1990826306 cites W2041910569 @default.
• W1990826306 cites W2049681451 @default.
• W1990826306 cites W2057693695 @default.
• W1990826306 cites W2078473845 @default.
• W1990826306 cites W2085878112 @default.
• W1990826306 cites W2123216167 @default.
• W1990826306 cites W2136118907 @default.
• W1990826306 cites W2144698355 @default.
• W1990826306 cites W4205488578 @default.
• W1990826306 doi "https://doi.org/10.1177/0883073891006002101" @default.
• W1990826306 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1940125" @default.
• W1990826306 hasPublicationYear "1991" @default.
• W1990826306 type Work @default.
• W1990826306 sameAs 1990826306 @default.
• W1990826306 citedByCount "139" @default.
• W1990826306 countsByYear W19908263062012 @default.
• W1990826306 countsByYear W19908263062013 @default.
• W1990826306 countsByYear W19908263062014 @default.
• W1990826306 countsByYear W19908263062015 @default.
• W1990826306 countsByYear W19908263062016 @default.
• W1990826306 countsByYear W19908263062018 @default.
• W1990826306 countsByYear W19908263062019 @default.
• W1990826306 countsByYear W19908263062020 @default.
• W1990826306 countsByYear W19908263062021 @default.
• W1990826306 crossrefType "journal-article" @default.
• W1990826306 hasAuthorship W1990826306A5005910163 @default.
• W1990826306 hasAuthorship W1990826306A5040726455 @default.
• W1990826306 hasAuthorship W1990826306A5044265198 @default.
• W1990826306 hasAuthorship W1990826306A5046418848 @default.
• W1990826306 hasAuthorship W1990826306A5080857249 @default.
• W1990826306 hasAuthorship W1990826306A5084454925 @default.
• W1990826306 hasConcept C118552586 @default.
• W1990826306 hasConcept C121332964 @default.
• W1990826306 hasConcept C126322002 @default.
• W1990826306 hasConcept C142424586 @default.
• W1990826306 hasConcept C187212893 @default.
• W1990826306 hasConcept C197934379 @default.
• W1990826306 hasConcept C2775858608 @default.
• W1990826306 hasConcept C2777683783 @default.
• W1990826306 hasConcept C2778186239 @default.
• W1990826306 hasConcept C2778201146 @default.
• W1990826306 hasConcept C2778375690 @default.
• W1990826306 hasConcept C2778980267 @default.
• W1990826306 hasConcept C2779034229 @default.
• W1990826306 hasConcept C2779546488 @default.
• W1990826306 hasConcept C2779888125 @default.
• W1990826306 hasConcept C2780837902 @default.
• W1990826306 hasConcept C42219234 @default.
• W1990826306 hasConcept C71924100 @default.
• W1990826306 hasConcept C87355193 @default.
• W1990826306 hasConceptScore W1990826306C118552586 @default.
• W1990826306 hasConceptScore W1990826306C121332964 @default.
• W1990826306 hasConceptScore W1990826306C126322002 @default.
• W1990826306 hasConceptScore W1990826306C142424586 @default.
• W1990826306 hasConceptScore W1990826306C187212893 @default.
• W1990826306 hasConceptScore W1990826306C197934379 @default.
• W1990826306 hasConceptScore W1990826306C2775858608 @default.
• W1990826306 hasConceptScore W1990826306C2777683783 @default.
• W1990826306 hasConceptScore W1990826306C2778186239 @default.
• W1990826306 hasConceptScore W1990826306C2778201146 @default.
• W1990826306 hasConceptScore W1990826306C2778375690 @default.
• W1990826306 hasConceptScore W1990826306C2778980267 @default.
• W1990826306 hasConceptScore W1990826306C2779034229 @default.
• W1990826306 hasConceptScore W1990826306C2779546488 @default.
• W1990826306 hasConceptScore W1990826306C2779888125 @default.
• W1990826306 hasConceptScore W1990826306C2780837902 @default.
• W1990826306 hasConceptScore W1990826306C42219234 @default.
• W1990826306 hasConceptScore W1990826306C71924100 @default.
• W1990826306 hasConceptScore W1990826306C87355193 @default.
• W1990826306 hasIssue "2_suppl" @default.
• W1990826306 hasLocation W19908263061 @default.
• W1990826306 hasLocation W19908263062 @default.
• W1990826306 hasOpenAccess W1990826306 @default.
• W1990826306 hasPrimaryLocation W19908263061 @default.

• next