Matches in SemOpenAlex for { <https://semopenalex.org/work/W1990829362> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W1990829362 abstract "The results of a small pilot study provided new insights into the process of colon carcinogenesis. Background: The known risk factors for colorectal cancer (CRC) suggested that CRC resulted from the interaction of exposure to energy excess and to oxidative stress [McKeown-Eyssen G et al. pp 673-693 in “Endogenous Toxins” Wiley, 2010]. The suggestion was supported by: cellular studies that demonstrated the cytotoxicity and genotoxicity of excess energy substrate (fructose) with oxidative stress (H2O2); animal studies that showed a wide range of pathology associated with fructose-based diets when combined with oxidative stress; and clinical studies that described the association of advanced glycation end-products (AGEs) with chronic diseases associated with the Western lifestyle. Methods: A pilot case-control study at a hospital-based gastroenterology clinic was conducted to assess methods for future tests of the hypothesis. It was based on an analysis of plasma samples collected from patients with (n = 20) or without (n = 21) colonoscopy-demonstrated polyps. Results: Although as anticipated none of the differences between polyp and non-polyp plasma samples achieved statistical significance, there were unexpectedly strong associations of the concentrations of the endogenous plasma aldehydes, glyoxal and methylglyoxal (r = 0.92), and glyoxal and 4-hydroxynonenal (r = 0.52) across the collected samples. Conclusions: The associations were likely a consequence of the known interaction of endogenous aldehydes with oxidative stress: endogenous aldehydes increased oxidative stress; oxidative stress increased the formation of endogenous aldehydes [e.g. Vander Jagt DL. Drug Metab Drug Interact 2008;23:93-124]. The products of such interactions, AGEs and advanced lipid oxidation endproducts (ALEs), could explain the known accumulation of fluorescent lipofuscin observed with dysplastic adenomas. Impact: Exposure to endogenous aldehydes and oxidation products is complex. Endogenous aldehyde derived — AGEs could provide robust biomarkers of this exposure including information relating to the tissues, cells and cellular organelles affected. Citation Information: Cancer Prev Res 2010;3(12 Suppl):B34." @default.
- W1990829362 created "2016-06-24" @default.
- W1990829362 creator A5003266453 @default.
- W1990829362 creator A5012811704 @default.
- W1990829362 creator A5017118254 @default.
- W1990829362 creator A5035768415 @default.
- W1990829362 creator A5053558591 @default.
- W1990829362 creator A5054282833 @default.
- W1990829362 creator A5058479146 @default.
- W1990829362 creator A5063396591 @default.
- W1990829362 creator A5070336660 @default.
- W1990829362 creator A5073742440 @default.
- W1990829362 creator A5074206394 @default.
- W1990829362 creator A5087879819 @default.
- W1990829362 date "2010-12-01" @default.
- W1990829362 modified "2023-09-25" @default.
- W1990829362 title "Abstract B34: Association of endogenous oxidative and aldehyde stress: Implications for studies of colon carcinogenesis" @default.
- W1990829362 doi "https://doi.org/10.1158/1940-6207.prev-10-b34" @default.
- W1990829362 hasPublicationYear "2010" @default.
- W1990829362 type Work @default.
- W1990829362 sameAs 1990829362 @default.
- W1990829362 citedByCount "0" @default.
- W1990829362 crossrefType "proceedings-article" @default.
- W1990829362 hasAuthorship W1990829362A5003266453 @default.
- W1990829362 hasAuthorship W1990829362A5012811704 @default.
- W1990829362 hasAuthorship W1990829362A5017118254 @default.
- W1990829362 hasAuthorship W1990829362A5035768415 @default.
- W1990829362 hasAuthorship W1990829362A5053558591 @default.
- W1990829362 hasAuthorship W1990829362A5054282833 @default.
- W1990829362 hasAuthorship W1990829362A5058479146 @default.
- W1990829362 hasAuthorship W1990829362A5063396591 @default.
- W1990829362 hasAuthorship W1990829362A5070336660 @default.
- W1990829362 hasAuthorship W1990829362A5073742440 @default.
- W1990829362 hasAuthorship W1990829362A5074206394 @default.
- W1990829362 hasAuthorship W1990829362A5087879819 @default.
- W1990829362 hasConcept C114246631 @default.
- W1990829362 hasConcept C121608353 @default.
- W1990829362 hasConcept C126322002 @default.
- W1990829362 hasConcept C134018914 @default.
- W1990829362 hasConcept C147990577 @default.
- W1990829362 hasConcept C16613235 @default.
- W1990829362 hasConcept C170493617 @default.
- W1990829362 hasConcept C181199279 @default.
- W1990829362 hasConcept C185592680 @default.
- W1990829362 hasConcept C2776151105 @default.
- W1990829362 hasConcept C2778592357 @default.
- W1990829362 hasConcept C526805850 @default.
- W1990829362 hasConcept C55493867 @default.
- W1990829362 hasConcept C555283112 @default.
- W1990829362 hasConcept C71924100 @default.
- W1990829362 hasConcept C98274493 @default.
- W1990829362 hasConceptScore W1990829362C114246631 @default.
- W1990829362 hasConceptScore W1990829362C121608353 @default.
- W1990829362 hasConceptScore W1990829362C126322002 @default.
- W1990829362 hasConceptScore W1990829362C134018914 @default.
- W1990829362 hasConceptScore W1990829362C147990577 @default.
- W1990829362 hasConceptScore W1990829362C16613235 @default.
- W1990829362 hasConceptScore W1990829362C170493617 @default.
- W1990829362 hasConceptScore W1990829362C181199279 @default.
- W1990829362 hasConceptScore W1990829362C185592680 @default.
- W1990829362 hasConceptScore W1990829362C2776151105 @default.
- W1990829362 hasConceptScore W1990829362C2778592357 @default.
- W1990829362 hasConceptScore W1990829362C526805850 @default.
- W1990829362 hasConceptScore W1990829362C55493867 @default.
- W1990829362 hasConceptScore W1990829362C555283112 @default.
- W1990829362 hasConceptScore W1990829362C71924100 @default.
- W1990829362 hasConceptScore W1990829362C98274493 @default.
- W1990829362 hasLocation W19908293621 @default.
- W1990829362 hasOpenAccess W1990829362 @default.
- W1990829362 hasPrimaryLocation W19908293621 @default.
- W1990829362 hasRelatedWork W1546051338 @default.
- W1990829362 hasRelatedWork W1970995950 @default.
- W1990829362 hasRelatedWork W1982584484 @default.
- W1990829362 hasRelatedWork W1996150439 @default.
- W1990829362 hasRelatedWork W1997732467 @default.
- W1990829362 hasRelatedWork W2063321102 @default.
- W1990829362 hasRelatedWork W2064210027 @default.
- W1990829362 hasRelatedWork W2095001124 @default.
- W1990829362 hasRelatedWork W2114859605 @default.
- W1990829362 hasRelatedWork W2119165883 @default.
- W1990829362 hasRelatedWork W2120112210 @default.
- W1990829362 hasRelatedWork W2169038643 @default.
- W1990829362 hasRelatedWork W2174359622 @default.
- W1990829362 hasRelatedWork W2339944119 @default.
- W1990829362 hasRelatedWork W2708420747 @default.
- W1990829362 hasRelatedWork W2767385072 @default.
- W1990829362 hasRelatedWork W2942479446 @default.
- W1990829362 hasRelatedWork W2953922003 @default.
- W1990829362 hasRelatedWork W3090564400 @default.
- W1990829362 hasRelatedWork W2325007070 @default.
- W1990829362 isParatext "false" @default.
- W1990829362 isRetracted "false" @default.
- W1990829362 magId "1990829362" @default.
- W1990829362 workType "article" @default.