Matches in SemOpenAlex for { <https://semopenalex.org/work/W1990841712> ?p ?o ?g. }
- W1990841712 endingPage "671" @default.
- W1990841712 startingPage "662" @default.
- W1990841712 abstract "ObjectiveTo evaluate the effectiveness of l-carnitine (LC) or l-acetyl-carnitine (LAC) or combined LC and LAC treatment in improving semen kinetic parameters and the total oxyradical scavenging capacity in semen.DesignPlacebo-controlled, double-blind, randomized trial.SettingAndrology unit, Department of Internal Medicine, Polytechnic University of Marche, Italy.Patient(s)Sixty infertile men, ages 20 to 40 years, with the following baseline sperm selection criteria: concentration >20 × 106/mL, sperm forward motility <50%, and normal sperm morphology >30%; 59 patients completed the study.Intervention(s)Patients underwent a double-blind therapy of LC 3 g/d, LAC 3 g/d, a combination of LC 2 g/d and LAC 1 g/d, or placebo. The study design was 1 month of run in, 6 months of therapy or placebo, and 3 months of follow-up evaluation.Main Outcome Measure(s)Variations in semen parameters used for patient selection, and variations in total oxyradical scavenging capacity of the seminal fluid.Result(s)Sperm cell motility (total and forward, including kinetic features determined by computer-assisted sperm analysis) increased in patients to whom LAC was administered both alone or in combination with LC; combined LC + LAC therapy led to a significant improvement of straight progressive velocity after 3 months. The total oxyradical scavenging capacity of the semen toward hydroxyl and peroxyl radicals also increased and was positively correlated with the improvement of kinetic features. Patients with lower baseline values of motility and total oxyradical scavenging capacity of the seminal fluid had a significantly higher probability of responding to the treatment.Conclusion(s)The administration of LC and LAC is effective in increasing sperm kinetic features in patients affected by idiopathic asthenozoospemia and improves the total oxyradical scavenging capacity of the seminal fluid in the same population. To evaluate the effectiveness of l-carnitine (LC) or l-acetyl-carnitine (LAC) or combined LC and LAC treatment in improving semen kinetic parameters and the total oxyradical scavenging capacity in semen. Placebo-controlled, double-blind, randomized trial. Andrology unit, Department of Internal Medicine, Polytechnic University of Marche, Italy. Sixty infertile men, ages 20 to 40 years, with the following baseline sperm selection criteria: concentration >20 × 106/mL, sperm forward motility <50%, and normal sperm morphology >30%; 59 patients completed the study. Patients underwent a double-blind therapy of LC 3 g/d, LAC 3 g/d, a combination of LC 2 g/d and LAC 1 g/d, or placebo. The study design was 1 month of run in, 6 months of therapy or placebo, and 3 months of follow-up evaluation. Variations in semen parameters used for patient selection, and variations in total oxyradical scavenging capacity of the seminal fluid. Sperm cell motility (total and forward, including kinetic features determined by computer-assisted sperm analysis) increased in patients to whom LAC was administered both alone or in combination with LC; combined LC + LAC therapy led to a significant improvement of straight progressive velocity after 3 months. The total oxyradical scavenging capacity of the semen toward hydroxyl and peroxyl radicals also increased and was positively correlated with the improvement of kinetic features. Patients with lower baseline values of motility and total oxyradical scavenging capacity of the seminal fluid had a significantly higher probability of responding to the treatment. The administration of LC and LAC is effective in increasing sperm kinetic features in patients affected by idiopathic asthenozoospemia and improves the total oxyradical scavenging capacity of the seminal fluid in the same population." @default.
- W1990841712 created "2016-06-24" @default.
- W1990841712 creator A5005843927 @default.
- W1990841712 creator A5037928577 @default.
- W1990841712 creator A5048189170 @default.
- W1990841712 creator A5063830261 @default.
- W1990841712 creator A5077697062 @default.
- W1990841712 creator A5087069678 @default.
- W1990841712 date "2005-09-01" @default.
- W1990841712 modified "2023-10-11" @default.
- W1990841712 title "Placebo-controlled double-blind randomized trial on the use of l-carnitine, l-acetylcarnitine, or combined l-carnitine and l-acetylcarnitine in men with idiopathic asthenozoospermia" @default.
- W1990841712 cites W1505704931 @default.
- W1990841712 cites W163461100 @default.
- W1990841712 cites W1972594203 @default.
- W1990841712 cites W1978140562 @default.
- W1990841712 cites W1980606066 @default.
- W1990841712 cites W1983662609 @default.
- W1990841712 cites W1994291765 @default.
- W1990841712 cites W2002855991 @default.
- W1990841712 cites W2002921346 @default.
- W1990841712 cites W2007476858 @default.
- W1990841712 cites W2018172212 @default.
- W1990841712 cites W2033135452 @default.
- W1990841712 cites W2040440691 @default.
- W1990841712 cites W2043771612 @default.
- W1990841712 cites W2053357824 @default.
- W1990841712 cites W2055493372 @default.
- W1990841712 cites W2063598002 @default.
- W1990841712 cites W2071103249 @default.
- W1990841712 cites W2102083512 @default.
- W1990841712 cites W2112621673 @default.
- W1990841712 cites W2116932540 @default.
- W1990841712 cites W2119898457 @default.
- W1990841712 cites W2129074344 @default.
- W1990841712 cites W2129831624 @default.
- W1990841712 cites W2131345656 @default.
- W1990841712 cites W2131748549 @default.
- W1990841712 cites W2134032476 @default.
- W1990841712 cites W2168396948 @default.
- W1990841712 cites W2241490343 @default.
- W1990841712 doi "https://doi.org/10.1016/j.fertnstert.2005.03.064" @default.
- W1990841712 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16169400" @default.
- W1990841712 hasPublicationYear "2005" @default.
- W1990841712 type Work @default.
- W1990841712 sameAs 1990841712 @default.
- W1990841712 citedByCount "175" @default.
- W1990841712 countsByYear W19908417122012 @default.
- W1990841712 countsByYear W19908417122013 @default.
- W1990841712 countsByYear W19908417122014 @default.
- W1990841712 countsByYear W19908417122015 @default.
- W1990841712 countsByYear W19908417122016 @default.
- W1990841712 countsByYear W19908417122017 @default.
- W1990841712 countsByYear W19908417122018 @default.
- W1990841712 countsByYear W19908417122019 @default.
- W1990841712 countsByYear W19908417122020 @default.
- W1990841712 countsByYear W19908417122021 @default.
- W1990841712 countsByYear W19908417122022 @default.
- W1990841712 countsByYear W19908417122023 @default.
- W1990841712 crossrefType "journal-article" @default.
- W1990841712 hasAuthorship W1990841712A5005843927 @default.
- W1990841712 hasAuthorship W1990841712A5037928577 @default.
- W1990841712 hasAuthorship W1990841712A5048189170 @default.
- W1990841712 hasAuthorship W1990841712A5063830261 @default.
- W1990841712 hasAuthorship W1990841712A5077697062 @default.
- W1990841712 hasAuthorship W1990841712A5087069678 @default.
- W1990841712 hasBestOaLocation W19908417121 @default.
- W1990841712 hasConcept C126322002 @default.
- W1990841712 hasConcept C134018914 @default.
- W1990841712 hasConcept C140793950 @default.
- W1990841712 hasConcept C142724271 @default.
- W1990841712 hasConcept C16685009 @default.
- W1990841712 hasConcept C168563851 @default.
- W1990841712 hasConcept C204787440 @default.
- W1990841712 hasConcept C27081682 @default.
- W1990841712 hasConcept C2777022797 @default.
- W1990841712 hasConcept C2777338322 @default.
- W1990841712 hasConcept C2777553358 @default.
- W1990841712 hasConcept C2777632594 @default.
- W1990841712 hasConcept C2777688143 @default.
- W1990841712 hasConcept C2778093475 @default.
- W1990841712 hasConcept C2778435403 @default.
- W1990841712 hasConcept C2779234561 @default.
- W1990841712 hasConcept C2781087480 @default.
- W1990841712 hasConcept C54355233 @default.
- W1990841712 hasConcept C71924100 @default.
- W1990841712 hasConcept C86803240 @default.
- W1990841712 hasConcept C90924648 @default.
- W1990841712 hasConceptScore W1990841712C126322002 @default.
- W1990841712 hasConceptScore W1990841712C134018914 @default.
- W1990841712 hasConceptScore W1990841712C140793950 @default.
- W1990841712 hasConceptScore W1990841712C142724271 @default.
- W1990841712 hasConceptScore W1990841712C16685009 @default.
- W1990841712 hasConceptScore W1990841712C168563851 @default.
- W1990841712 hasConceptScore W1990841712C204787440 @default.
- W1990841712 hasConceptScore W1990841712C27081682 @default.
- W1990841712 hasConceptScore W1990841712C2777022797 @default.
- W1990841712 hasConceptScore W1990841712C2777338322 @default.
- W1990841712 hasConceptScore W1990841712C2777553358 @default.