FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1990854586> ?p ?o ?g. }

• W1990854586 endingPage "69" @default.
• W1990854586 startingPage "59" @default.
• W1990854586 abstract "Summary Macrophage function has been demonstrated to be subject to modulation by progesterone. However, as this steroid hormone can act through the glucocorticoid receptor as well as the progesterone receptor, the mechanism of action has not been precisely characterized. To determine the mode of action, we compared the ability of progesterone, norgestrel (a synthetic progesterone‐receptor‐specific agonist) and dexamethasone (a synthetic glucocorticoid receptor agonist) to modulate macrophage function following stimulation of the Toll‐like receptor‐4 (TLR‐4) ligand lipopolysaccharide (LPS). The results demonstrate that following stimulation of TLR‐4 with LPS and cotreatment with either progesterone or dexamethasone, but not norgestrel, there is a significant reduction in nitric oxide (NO) production, indicating that this progesterone‐mediated effect is through ligation of the glucocorticoid receptor. In contrast, LPS‐induced interleukin‐12 (IL‐12) production could be downregulated by all three steroids, indicating that ligation by progesterone of either the glucocorticoid or the progesterone receptors or both could mediate this effect. While progesterone downmodulated NO‐mediated killing of Leishmania donovani by activated macrophages in vitro , most probably via the glucocorticoid receptor, it had little effect on Toxoplasma gondii growth in these cells. This would suggest that progesterone‐mediated increased susceptibility to T. gondii during pregnancy is more likely to be related to the ability of the hormone to downregulate IL‐12 production and a type‐1 response utilizing the progesterone as well as the glucocorticoid receptors." @default.
• W1990854586 created "2016-06-24" @default.
• W1990854586 creator A5000406748 @default.
• W1990854586 creator A5009739522 @default.
• W1990854586 creator A5010559786 @default.
• W1990854586 creator A5012625525 @default.
• W1990854586 creator A5017519824 @default.
• W1990854586 creator A5040139721 @default.
• W1990854586 creator A5042745349 @default.
• W1990854586 creator A5074277094 @default.
• W1990854586 date "2008-08-06" @default.
• W1990854586 modified "2023-10-15" @default.
• W1990854586 title "Toll-like receptor-4-mediated macrophage activation is differentially regulated by progesterone via the glucocorticoid and progesterone receptors" @default.
• W1990854586 cites W1505580575 @default.
• W1990854586 cites W1519441922 @default.
• W1990854586 cites W1539476130 @default.
• W1990854586 cites W1544586439 @default.
• W1990854586 cites W1545910465 @default.
• W1990854586 cites W1582870359 @default.
• W1990854586 cites W1585200928 @default.
• W1990854586 cites W1647608010 @default.
• W1990854586 cites W1668732801 @default.
• W1990854586 cites W1853964654 @default.
• W1990854586 cites W1855297813 @default.
• W1990854586 cites W1919417951 @default.
• W1990854586 cites W1943005777 @default.
• W1990854586 cites W1951353479 @default.
• W1990854586 cites W1970140452 @default.
• W1990854586 cites W1973189530 @default.
• W1990854586 cites W1976775782 @default.
• W1990854586 cites W1983895762 @default.
• W1990854586 cites W1988956302 @default.
• W1990854586 cites W1990802251 @default.
• W1990854586 cites W1996485781 @default.
• W1990854586 cites W1997648662 @default.
• W1990854586 cites W2001963326 @default.
• W1990854586 cites W2008765551 @default.
• W1990854586 cites W2009165567 @default.
• W1990854586 cites W2009446037 @default.
• W1990854586 cites W2011060686 @default.
• W1990854586 cites W2011332253 @default.
• W1990854586 cites W2022398608 @default.
• W1990854586 cites W2022980453 @default.
• W1990854586 cites W2023750726 @default.
• W1990854586 cites W2025257148 @default.
• W1990854586 cites W2029144058 @default.
• W1990854586 cites W2041001602 @default.
• W1990854586 cites W2046255839 @default.
• W1990854586 cites W2047043504 @default.
• W1990854586 cites W2048694075 @default.
• W1990854586 cites W2052701260 @default.
• W1990854586 cites W2057028848 @default.
• W1990854586 cites W2061961359 @default.
• W1990854586 cites W2065593228 @default.
• W1990854586 cites W2067820053 @default.
• W1990854586 cites W2069206672 @default.
• W1990854586 cites W2079550192 @default.
• W1990854586 cites W2080846047 @default.
• W1990854586 cites W2085245070 @default.
• W1990854586 cites W2105699711 @default.
• W1990854586 cites W2112175677 @default.
• W1990854586 cites W2113743444 @default.
• W1990854586 cites W2113930416 @default.
• W1990854586 cites W2117079340 @default.
• W1990854586 cites W2122706104 @default.
• W1990854586 cites W2127449050 @default.
• W1990854586 cites W2129854312 @default.
• W1990854586 cites W2132709753 @default.
• W1990854586 cites W2133868033 @default.
• W1990854586 cites W2135460095 @default.
• W1990854586 cites W2136607893 @default.
• W1990854586 cites W2145330496 @default.
• W1990854586 cites W2147095804 @default.
• W1990854586 cites W2163021526 @default.
• W1990854586 cites W2189495881 @default.
• W1990854586 cites W2268907643 @default.
• W1990854586 cites W2291798824 @default.
• W1990854586 cites W26282693 @default.
• W1990854586 cites W4232023013 @default.
• W1990854586 cites W4232260956 @default.
• W1990854586 cites W4246245551 @default.
• W1990854586 cites W4254356607 @default.
• W1990854586 doi "https://doi.org/10.1111/j.1365-2567.2008.02820.x" @default.
• W1990854586 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2526260" @default.
• W1990854586 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18373668" @default.
• W1990854586 hasPublicationYear "2008" @default.
• W1990854586 type Work @default.
• W1990854586 sameAs 1990854586 @default.
• W1990854586 citedByCount "94" @default.
• W1990854586 countsByYear W19908545862012 @default.
• W1990854586 countsByYear W19908545862013 @default.
• W1990854586 countsByYear W19908545862014 @default.
• W1990854586 countsByYear W19908545862015 @default.
• W1990854586 countsByYear W19908545862016 @default.
• W1990854586 countsByYear W19908545862017 @default.
• W1990854586 countsByYear W19908545862018 @default.
• W1990854586 countsByYear W19908545862019 @default.
• W1990854586 countsByYear W19908545862020 @default.

• next