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• W1990855979 abstract "Background: Porphyromonas gingivalis (Pg) is one of the most harmful periodontal pathogens and it has been reported that Pg is associated with preterm birth (PTB), intrauterine growth retardation (IUGR) and pregnancy-induced hypertension (PIH), discovered by animal experiments and clinical research. The relationship between adverse pregnancy outcomes and maternal antibody response to Pg is controversial. On the other hand, the serum C-reactive protein (CRP) has been recognised as a reliable serum marker of periodontal disease. Aims: To determine the significance of antibody responses to Pg affecting pregnancy outcomes in the first trimester. Methods: A case–control study was carried out on women with PTB (n = 58), IUGR (n = 91), PIH (n = 32) and without any complications (control, n = 98). The serum level of the CRP and IgG1 against 40-kDa outer membrane protein of Pg (anti-40-kDa OMP Pg-IgG1) in the first trimester was measured. Results: The IUGR group, and PTB patients whose placentas were diagnosed as chorioamnionitis or whose vaginal flora included Lactobacilli, showed a lower level of anti-40-kDa OMP Pg-IgG1 than the control group. There was no difference in the serum CRP level between each case group and control group. Conclusions: These results suggest that a lack of humoral immunity against Pg in early pregnancy is associated with IUGR and some PTB." @default.
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• W1990855979 date "2009-04-01" @default.
• W1990855979 modified "2023-09-27" @default.
• W1990855979 title "Antibody responses toPorphyromonas gingivalisouter membrane protein in the first trimester" @default.
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• W1990855979 doi "https://doi.org/10.1111/j.1479-828x.2009.00958.x" @default.
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