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- W1990865384 abstract "Efficient routes to access the 2, 3, 4, and 6 registers of the nodulisporic acid (NsA) side chain are disclosed. A mild one-carbon, Ph(2)CdoublebondNCH(2)CtriplebondN mediated homologation of NsA's 3-aldehyde permitted access to the 4-register. Curtius reaction of NsA's 3-acid yielded the corresponding 2-aldehyde 4 from which the unnatural Delta(2,3)-olefin isomer 2b was obtained. In addition, Arndt-Eistert reactions of the parent NsA permitted a one-carbon homologation to the 6 register. These efforts identified new analogues with significant flea activity and illustrated the biological significance of unsaturation at the 1,2 register." @default.
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- W1990865384 date "2003-01-01" @default.
- W1990865384 modified "2023-10-14" @default.
- W1990865384 title "Nodulisporic acid side-Chain modifications: access to the 2″, 3″, 4″, and 6″ registers" @default.
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- W1990865384 doi "https://doi.org/10.1016/s0960-894x(02)00826-0" @default.
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