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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1990873521> ?p ?o ?g. }

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• W1990873521 abstract "Extracellular adenosine induced apoptosis of MCF-7 human breast cancer cells in a concentration (10μM-10mM)- and treatment time (24-72h)-dependent manner, and the effect was inhibited by the adenosine transporter inhibitor dipyridamole, but not an inhibitor of adenosine kinase, an inhibitor of AMP-activated protein kinase, or inhibitors for A(1), A(2a), A(2b), and A(3) adenosine receptors. No significant activation of caspase-7, -8, or -9 was obtained with adenosine. Adenosine promoted translocation of apoptosis-inducing factor (AIF)-homologous mitochondrion-associated inducer of death (AMID) from the cytosol into the nucleus, although the total amount of AMID was not affected. Adenosine-induced MCF-7 cell death was abrogated by knocking-down AMID. The results of the present study indicate that intracellularly transported adenosine induces MCF-7 cell apoptosis by accumulating AMID in the nucleus in a caspase-independent manner." @default.
• W1990873521 created "2016-06-24" @default.
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• W1990873521 date "2012-08-01" @default.
• W1990873521 modified "2023-09-30" @default.
• W1990873521 title "Intracellularly transported adenosine induces MCF-7 human breast cancer cells by accumulating AMID in the nucleus" @default.
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• W1990873521 doi "https://doi.org/10.1016/j.canlet.2012.02.023" @default.
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