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- W1990877047 abstract "Funisitis is the histologic counterpart of the fetal inflammatory response syndrome, which is a multisystem disorder associated with impending preterm delivery and adverse short- and long-term neonatal outcome (i.e., cerebral palsy). However, this association was described in preterm gestation and there are questions whether this applies to term gestation, particularly in medico-legal cases of cerebral palsy at term. The objective of this study was to determine if there is a relationship between AF white blood cell (WBC) count and funisitis in term pregnancies. This study included 832 patients who delivered term singleton neonates within 72 hours of amniocentesis. AF was cultured for aerobic and anaerobic bacteria, as well as for mycoplasmas. Funisitis was diagnosed in the presence of neutrophil infiltration into the umbilical vessel walls or Wharton's jelly. AF WBC count was determined with a hemocytometer chamber. 1) Funisitis was present in 3.6% (30/832) of patients; 2) A positive AF culture was more common in cases with funisitis than in those without funisitis (17% vs 5%; p < 0.05); 3) Patients with funisitis had a higher median AF WBC count than those without funisitis (median, > 1000 cells/mm3; range, 0- > 1000 cells/mm3; vs median, 2 cells/mm3; range, 0- > 1000 cells/mm3; p < 0.001); 4) The diagnostic indices of AF WBC (cutoff, 18 cells/mm3) in the identification of funisitis were: a sensitivity of 70%, a specificity of 81%, a positive predictive value of 12%, and a negative predictive value of 99%. 1) An elevated AF WBC count is associated with funisitis in term gestations; 2) Funisitis is associated with AF infection. We propose that the diagnosis of funisitis in the placenta is evidence of prior exposure of the fetus to an inflammatory stimulus and can have medico-legal value in the defense of cases of cerebral palsy at term." @default.
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- W1990877047 date "2005-12-01" @default.
- W1990877047 modified "2023-09-26" @default.
- W1990877047 title "The relationship between amniotic fluid white blood cell count and funisitis at term" @default.
- W1990877047 doi "https://doi.org/10.1016/j.ajog.2005.10.398" @default.
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