FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1990877090> ?p ?o ?g. }

• W1990877090 endingPage "5705" @default.
• W1990877090 startingPage "5692" @default.
• W1990877090 abstract "A methodology for flexible fitting of all-atom high-resolution structures into low-resolution cryoelectron microscopy (cryo-EM) maps is presented. Flexibility of the modeled structure is simulated by classical molecular dynamics and an additional effective potential is introduced to enhance the fitting process. The additional potential is proportional to the correlation coefficient between the experimental cryo-EM map and a synthetic map generated for an all-atom structure being fitted to the map. The additional forces are calculated as a gradient of the correlation coefficient. During the molecular dynamics simulations under the additional forces, the molecule undergoes a conformational transition that maximizes the correlation coefficient, which results in a high-accuracy fit of all-atom structure into a cryo-EM map. Using five test proteins that exhibit structural rearrangement during their biological activity, we demonstrate performance of our method. We also test our method on the experimental cryo-EM of elongation factor G and show that the model obtained is comparable to previous studies. In addition, we show that overfitting can be avoided by assessing the quality of the fitted model in terms of correlation coefficient and secondary structure preservation." @default.
• W1990877090 created "2016-06-24" @default.
• W1990877090 creator A5038233475 @default.
• W1990877090 creator A5090638713 @default.
• W1990877090 date "2008-12-01" @default.
• W1990877090 modified "2023-10-16" @default.
• W1990877090 title "Flexible Fitting of High-Resolution X-Ray Structures into Cryoelectron Microscopy Maps Using Biased Molecular Dynamics Simulations" @default.
• W1990877090 cites W1533620685 @default.
• W1990877090 cites W1534892601 @default.
• W1990877090 cites W1677689941 @default.
• W1990877090 cites W1966323820 @default.
• W1990877090 cites W1969723894 @default.
• W1990877090 cites W1988200737 @default.
• W1990877090 cites W1992801972 @default.
• W1990877090 cites W2001079548 @default.
• W1990877090 cites W2002767842 @default.
• W1990877090 cites W2007107624 @default.
• W1990877090 cites W2008708467 @default.
• W1990877090 cites W2011048374 @default.
• W1990877090 cites W2012983065 @default.
• W1990877090 cites W2014719041 @default.
• W1990877090 cites W2016113157 @default.
• W1990877090 cites W2016367858 @default.
• W1990877090 cites W2020628076 @default.
• W1990877090 cites W2021419438 @default.
• W1990877090 cites W2026708744 @default.
• W1990877090 cites W2032219149 @default.
• W1990877090 cites W2040646101 @default.
• W1990877090 cites W2046141572 @default.
• W1990877090 cites W2054511300 @default.
• W1990877090 cites W2054702783 @default.
• W1990877090 cites W2056331547 @default.
• W1990877090 cites W2057400263 @default.
• W1990877090 cites W2058690225 @default.
• W1990877090 cites W2069920107 @default.
• W1990877090 cites W2071609593 @default.
• W1990877090 cites W2072575434 @default.
• W1990877090 cites W2072973641 @default.
• W1990877090 cites W2073701103 @default.
• W1990877090 cites W2079081359 @default.
• W1990877090 cites W2079865852 @default.
• W1990877090 cites W2082913409 @default.
• W1990877090 cites W2090492074 @default.
• W1990877090 cites W2093547815 @default.
• W1990877090 cites W2097225375 @default.
• W1990877090 cites W2099598754 @default.
• W1990877090 cites W2105254477 @default.
• W1990877090 cites W2105321472 @default.
• W1990877090 cites W2110936528 @default.
• W1990877090 cites W2111523821 @default.
• W1990877090 cites W2118233996 @default.
• W1990877090 cites W2119342149 @default.
• W1990877090 cites W2122199548 @default.
• W1990877090 cites W2122308713 @default.
• W1990877090 cites W2128897252 @default.
• W1990877090 cites W2139477024 @default.
• W1990877090 cites W2140889378 @default.
• W1990877090 cites W2150008490 @default.
• W1990877090 cites W2150262128 @default.
• W1990877090 cites W2150987569 @default.
• W1990877090 cites W2152997134 @default.
• W1990877090 cites W2158314430 @default.
• W1990877090 cites W2163689612 @default.
• W1990877090 doi "https://doi.org/10.1529/biophysj.108.139451" @default.
• W1990877090 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2599853" @default.
• W1990877090 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18849406" @default.
• W1990877090 hasPublicationYear "2008" @default.
• W1990877090 type Work @default.
• W1990877090 sameAs 1990877090 @default.
• W1990877090 citedByCount "99" @default.
• W1990877090 countsByYear W19908770902012 @default.
• W1990877090 countsByYear W19908770902013 @default.
• W1990877090 countsByYear W19908770902014 @default.
• W1990877090 countsByYear W19908770902015 @default.
• W1990877090 countsByYear W19908770902016 @default.
• W1990877090 countsByYear W19908770902017 @default.
• W1990877090 countsByYear W19908770902018 @default.
• W1990877090 countsByYear W19908770902019 @default.
• W1990877090 countsByYear W19908770902020 @default.
• W1990877090 countsByYear W19908770902021 @default.
• W1990877090 countsByYear W19908770902022 @default.
• W1990877090 countsByYear W19908770902023 @default.
• W1990877090 crossrefType "journal-article" @default.
• W1990877090 hasAuthorship W1990877090A5038233475 @default.
• W1990877090 hasAuthorship W1990877090A5090638713 @default.
• W1990877090 hasBestOaLocation W19908770901 @default.
• W1990877090 hasConcept C105795698 @default.
• W1990877090 hasConcept C120665830 @default.
• W1990877090 hasConcept C121332964 @default.
• W1990877090 hasConcept C138268822 @default.
• W1990877090 hasConcept C145912823 @default.
• W1990877090 hasConcept C147080431 @default.
• W1990877090 hasConcept C147597530 @default.
• W1990877090 hasConcept C149635348 @default.
• W1990877090 hasConcept C154945302 @default.
• W1990877090 hasConcept C185592680 @default.
• W1990877090 hasConcept C186060115 @default.
• W1990877090 hasConcept C22019652 @default.

• next