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• W1990881270 abstract "A special indication for the use of prothrombin complex concentrates (PCC) and their derivatives is the treatment of bleeding episodes in patients with an antibody (inhibitor) against factor VIII (FVIII) or factor IX (FIX). The presence of such an inhibitor inactivates the injected FVIII or FIX so that hemostasis cannot be achieved or is delayed. Breen and Tullis [ 1 Breen F.A. Tullis J.L. Prothrombin concentrates in treatment of Christmas disease and allied disorders. JAMA. 1969; 208: 1848-1852 Crossref PubMed Scopus (43) Google Scholar ] in 1969 were the first to note that a PCC had a hemostyptic effect in a patient with hemophilia A and an inhibitor against FVIII. In 1972, Fekete et al. [ 2 Fekete LF, Holst SL, Peetom F, Deveber LL. Auto-factor IX concentrate: A new therapeutic approach to treatment of haemophilia A patients with inhibitors. 14th Intern. Congress of Hematology. Brazil, 1972, A295. Google Scholar ] reported that a spontaneously activated PCC (Auto-Factor-IX Hyland [Hyland, Glendale, CA, USA]) was effective in patients with FVIII inhibitors. This observation was confirmed in a study of a larger number of patients by Kurczynsky and Penner in 1974 [ 3 Kurczynsky E.M. Penner J.A. Activated prothrombin concentrate for patients with factor VIII inhibitors. N Engl J Med. 1974; 291: 164-167 Crossref PubMed Scopus (135) Google Scholar ]." @default.
• W1990881270 created "2016-06-24" @default.
• W1990881270 creator A5033504351 @default.
• W1990881270 date "1999-08-01" @default.
• W1990881270 modified "2023-09-27" @default.
• W1990881270 title "Clinical Efficacy of Prothrombin Complex Concentrates and Recombinant Factor VIIa in the Treatment of Bleeding Episodes in Patients with Factor VIII and IX Inhibitors" @default.
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• W1990881270 doi "https://doi.org/10.1016/s0049-3848(99)00082-1" @default.
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