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• W1990883896 abstract "Estrogen-induced signaling pathways in hippocampal and cortical neurons converge upon the mitochondria to enhance mitochondrial function and to sustain aerobic glycolysis and citric acid cycle-driven oxidative phosphorylation and ATP generation. Data derived from experimental and clinical paradigms investigating estrogen intervention in healthy systems and prior to neurodegenerative insult indicate enhanced neural defense and survival through maintenance of calcium homeostasis, enhanced glycolysis coupled to the citric acid cycle (aerobic glycolysis), sustained and enhanced mitochondrial function, protection against free radical damage, efficient cholesterol trafficking and beta amyloid clearance. The convergence of E2 mechanisms of action onto mitochondrial is also a potential point of vulnerability when activated in a degenerating neural system and could exacerbate the degenerative processes through increased load on dysregulated calcium homeostasis. The data indicate that as the continuum of neurological health progresses from healthy to unhealthy so too do the benefits of estrogen or hormone therapy. If neurons are healthy at the time of estrogen exposure, their response to estrogen is beneficial for both neuronal survival and neurological function. In contrast, if neurological health is compromised, estrogen exposure over time exacerbates neurological demise. The healthy cell bias of estrogen action hypothesis provides a lens through which to assess the disparities in outcomes across the basic to clinical domains of scientific inquiry and on which to predict future applications of estrogen and hormone therapeutic interventions sustain neurological health and to prevent age-associated neurodegenerative diseases such as Alzheimer's. Overall, E2 promotes the energetic capacity of brain mitochondria by maximizing aerobic glycolysis (oxidative phosphorylation coupled to pyruvate metabolism). The enhanced aerobic glycolysis in the aging brain would be predicted to prevent conversion of the brain to using alternative sources of fuel such as the ketone body pathway characteristic of Alzheimer's." @default.
• W1990883896 created "2016-06-24" @default.
• W1990883896 creator A5005920250 @default.
• W1990883896 date "2008-10-01" @default.
• W1990883896 modified "2023-10-11" @default.
• W1990883896 title "Estrogen regulation of glucose metabolism and mitochondrial function: Therapeutic implications for prevention of Alzheimer's disease" @default.
• W1990883896 cites W1518422235 @default.
• W1990883896 cites W1574110183 @default.
• W1990883896 cites W1661647511 @default.
• W1990883896 cites W1808478632 @default.
• W1990883896 cites W1809411463 @default.
• W1990883896 cites W1838634581 @default.
• W1990883896 cites W1963092557 @default.
• W1990883896 cites W1963783263 @default.
• W1990883896 cites W1970257032 @default.
• W1990883896 cites W1972648551 @default.
• W1990883896 cites W1977230392 @default.
• W1990883896 cites W1978728630 @default.
• W1990883896 cites W1978769917 @default.
• W1990883896 cites W1986144956 @default.
• W1990883896 cites W1986974335 @default.
• W1990883896 cites W1988310632 @default.
• W1990883896 cites W1988398482 @default.
• W1990883896 cites W1989643757 @default.
• W1990883896 cites W1989868932 @default.
• W1990883896 cites W1990477938 @default.
• W1990883896 cites W1991853401 @default.
• W1990883896 cites W1992571809 @default.
• W1990883896 cites W1992670283 @default.
• W1990883896 cites W1994526084 @default.
• W1990883896 cites W1995192985 @default.
• W1990883896 cites W1996660429 @default.
• W1990883896 cites W1999031962 @default.
• W1990883896 cites W2002737481 @default.
• W1990883896 cites W2005016581 @default.
• W1990883896 cites W2007917384 @default.
• W1990883896 cites W2011633018 @default.
• W1990883896 cites W2012080584 @default.
• W1990883896 cites W2017331308 @default.
• W1990883896 cites W2018090541 @default.
• W1990883896 cites W2018692335 @default.
• W1990883896 cites W2020019869 @default.
• W1990883896 cites W2021612112 @default.
• W1990883896 cites W2023292537 @default.
• W1990883896 cites W2023880391 @default.
• W1990883896 cites W2025624761 @default.
• W1990883896 cites W2027388925 @default.
• W1990883896 cites W2028573466 @default.
• W1990883896 cites W2030884639 @default.
• W1990883896 cites W2034341467 @default.
• W1990883896 cites W2034639126 @default.
• W1990883896 cites W2036835033 @default.
• W1990883896 cites W2039194156 @default.
• W1990883896 cites W2039940349 @default.
• W1990883896 cites W2041695109 @default.
• W1990883896 cites W2042197302 @default.
• W1990883896 cites W2043274957 @default.
• W1990883896 cites W2044241508 @default.
• W1990883896 cites W2045305984 @default.
• W1990883896 cites W2046114632 @default.
• W1990883896 cites W2047399305 @default.
• W1990883896 cites W2048901742 @default.
• W1990883896 cites W2049111053 @default.
• W1990883896 cites W2059819603 @default.
• W1990883896 cites W2064482843 @default.
• W1990883896 cites W2066298795 @default.
• W1990883896 cites W2067099461 @default.
• W1990883896 cites W2070746053 @default.
• W1990883896 cites W2071907674 @default.
• W1990883896 cites W2072881225 @default.
• W1990883896 cites W2073672013 @default.
• W1990883896 cites W2075173841 @default.
• W1990883896 cites W2077529180 @default.
• W1990883896 cites W2079495133 @default.
• W1990883896 cites W2080274663 @default.
• W1990883896 cites W2083880873 @default.
• W1990883896 cites W2086974237 @default.
• W1990883896 cites W2087139961 @default.
• W1990883896 cites W2087696772 @default.
• W1990883896 cites W2089964981 @default.
• W1990883896 cites W2090496772 @default.
• W1990883896 cites W2092194262 @default.
• W1990883896 cites W2094021545 @default.
• W1990883896 cites W2096429475 @default.
• W1990883896 cites W2097290081 @default.
• W1990883896 cites W2098259195 @default.
• W1990883896 cites W2102117809 @default.
• W1990883896 cites W2103526903 @default.
• W1990883896 cites W2105754268 @default.
• W1990883896 cites W2109110436 @default.
• W1990883896 cites W2112152476 @default.
• W1990883896 cites W2113238381 @default.
• W1990883896 cites W2114729479 @default.
• W1990883896 cites W2118733200 @default.
• W1990883896 cites W2119791710 @default.
• W1990883896 cites W2128007559 @default.
• W1990883896 cites W2131266318 @default.
• W1990883896 cites W2131722081 @default.

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