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• W1990885536 abstract "Helicobacter pylori (Hp) infection is very common in Mediterranean countries, where there are many contaminated young people aged <20 years [11-40% serum positive for antibodies against Hp (aHp)]. In this study 98 children (46 M, 52 F), aged 17 months to 15 years (Median 10 y), suffering from chronic abdominal pain, vomiting or hematemesis, were studied. In all of the above patients (pts) Hp was identified in the histological examination (HE) and cultures of gastric mucosa (GM). The therapeutic scheme given was metronidazole (M), amoxicillin (A), and tripotassium dicitratobismuthate (B), in the usual dosages, for 30 days. Oesophagogastroduodenoscopy (OGD) was performed on the pts just before treatment was started, and 1 month to 2 years (Median 2 months) after they were off the medication. OGD was also performed on the serum positive for aHp parents and the siblings of the above pts. Biopsies were taken from duodenum, pylorus, gastric antrum-fundus, and oesophagus for HE, culture for identification of Hp and PCR for molecular typing of Hp strains. Serum IgG, IgA aHp (ELISA) were tested monthly for the first 6 months after the diagnosis of Hp gastritis was made and then 6-monthly for 1-4.5 years (Median 4 y). The results taken from the follow up of the pts studied were the following: 1) 75% of the children contaminated by Hp were found to be infected by different Hp strains from those of their parents. 50% of the above children and their siblings were also contaminated by different Hp strains. Different Hp strains were also identified in pylorus and fundus of only one parent, but in none of the infected children. 2) In 6% of serum negative for aHp children, Hp was found by HE and culture of the GM. 3) In 82% of the asymptomatic, serum positive for aHp siblings of the infected children, Hp was identified by the HE of the GM. Often (36%) the pathology of the GM of the asymptomatic siblings was worse than that of their symptomatic siblings'. 4) Treatment with F, A, B was effective in 93% of the pts. 5) In all the pts, where Hp was eradicated, serum aHp were negated within 35 days to 2 years (Median 3 months). The aHp remained steadily negative in all the children, who responded to the treatment. On the contrary, in all the cases of unsuccessful treatment serum aHp remained constantly positive. In conclusion, the new data taken from the 5-year follow-up of the studied pts is the following: 1) Intrafamilial spread of Hp occurs only in half of the infected children. Other extrafamilial sources of Hp infection must be looked into. 2) Negation of serum aHp is a useful index of Hp eradication. 3) Children eradicated from Hp are not reinfected even though there is serum aHp negation. 4) Asymptomatic children, serum positive for aHp, must be endoscoped and then treated, if Hp gastritis is found." @default.
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• W1990885536 date "1997-04-01" @default.
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• W1990885536 title "FIVE YEAR FOLLOW UP OF CHILDREN TREATED FOR HELICOBACTER PYLORI GASTRITIS" @default.
• W1990885536 doi "https://doi.org/10.1097/00005176-199704000-00138" @default.
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