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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1990888754> ?p ?o ?g. }

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• W1990888754 abstract "Transfer of a gene into stem cells with subsequent lineage-specific gene expression is a desired goal with many potential therapeutic applications. Retroviral vectors developed from murine leukemia viruses reproducibly transfer genes into murine stem cells, but are inefficient at gene insertion into stem cells of larger animals or man. A growing knowledge of stem cell biology suggests that this inefficiency reflects the quiescent state of stem cells, even when incubated in the presence of multiple cytokines and low expression of the receptor for amphotropic retroviral vectors. Alternative vector systems are being explored in an effort to overcome these barriers to stem cell-targeted gene transfer. Our work has shown that recombinant adeno-associated virus vectors, which have the potential for transducing quiescent cells, transfer, express and integrate a globin gene linked to its normal regulatory elements in human erythroid cells, but only at very high multiplicities of infection. The integrated genome was stable and the encoded globin gene was expressed at levels equivalent to a normal globin gene." @default.
• W1990888754 created "2016-06-24" @default.
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• W1990888754 date "1997-04-01" @default.
• W1990888754 modified "2023-09-26" @default.
• W1990888754 title "Gene transfer into hematopoietic cells" @default.
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• W1990888754 doi "https://doi.org/10.1002/stem.5530150816" @default.
• W1990888754 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9368332" @default.
• W1990888754 hasPublicationYear "1997" @default.
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