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- W1990900950 abstract "Osteoporosis is common in patients with chronic obstructive pulmonary disease (COPD). Data regarding the relationship between adipokines and bone mineral density (BMD) in this population is lacking. The purpose of this pilot study was to determine associations between the adipokines tumor necrosis factor-alpha (TNF-alpha), leptin, adiponectin and resistin, body composition, and BMD in men with severe COPD. This was a cross-sectional study of men with severe COPD who visited the University of Colorado Hospital COPD Center. Bone density and parameters of body composition were measured by dual-energy X-ray absorptiometry. Twenty-three men were included (mean age = 66 years, mean percent predicted forced expiratory volume in one second = 32%). On bivariate analysis, there was no association between TNF-alpha and BMD. Parameters of body composition and serum concentrations of leptin and adiponectin were significantly associated with total hip and spine bone density. However, with partial correlation analysis, total body mass was the only independent predictor of total hip BMD, explaining approximately 50% of the variability. Overall, 18 out of 23 men enrolled (78%) had low bone density by T-score, and nine (39%) were classified as having osteoporosis. The men with osteoporosis had lower parameters of body composition, lower mean serum leptin concentrations, and a greater impairment in measures of lung function compared to the men without osteoporosis. We conclude that the effect of adipokines on BMD does not appear to be independent of body mass. However, larger studies are needed to further evaluate the relationship between adipokines, body weight, and BMD in patients with COPD." @default.
- W1990900950 created "2016-06-24" @default.
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- W1990900950 date "2009-07-01" @default.
- W1990900950 modified "2023-09-26" @default.
- W1990900950 title "The relationship between adipokines, body composition, and bone density in men with chronic obstructive pulmonary disease" @default.
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- W1990900950 doi "https://doi.org/10.2147/copd.s2745" @default.
- W1990900950 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2719257" @default.
- W1990900950 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19657401" @default.
- W1990900950 hasPublicationYear "2009" @default.
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