Matches in SemOpenAlex for { <https://semopenalex.org/work/W1990903847> ?p ?o ?g. }
- W1990903847 endingPage "1246" @default.
- W1990903847 startingPage "1240" @default.
- W1990903847 abstract "Caudal regions of the prefrontal cortex, including the dorsolateral (DLPFC) and ventrolateral (VLPFC) prefrontal cortex, are involved in essential cognitive functions such as working memory. In contrast, more rostral regions, such as the frontopolar cortex (FpC), have integrative functions among cognitive functions and thereby contribute crucially to real-world social activity. Previous functional magnetic resonance imaging studies have shown patients with schizophrenia had different DLPFC activity pattern in response to cognitive load changes compared to healthy controls; however, the spatial relationship between the caudal and rostral prefrontal activation has not been evaluated under less-constrained conditions.Twenty-six patients with schizophrenia and 26 age-, sex-, and premorbid-intelligence-matched healthy controls participated in this study. Hemodynamic changes during n-back working memory tasks with different cognitive loads were measured using multi-channel near-infrared spectroscopy (NIRS).Healthy controls showed significant task-related activity in the bilateral VLPFC and significant task-related decreased activity in the DLPFC, with greater signal changes when the task required more cognitive load. In contrast, patients with schizophrenia showed activation in the more rostral regions, including bilateral DLPFC and FpC. Neither decreased activity nor greater activation in proportion to elevated cognitive load occurred.This multi-channel NIRS study demonstrated that activation intensity did not increase in patients with schizophrenia associated with cognitive load changes, suggesting hypo-frontality as cognitive impairment in schizophrenia. On the other hand, patients had broader prefrontal activity in areas such as the bilateral DLPFC and FpC regions, thus suggesting a hyper-frontality compensatory response." @default.
- W1990903847 created "2016-06-24" @default.
- W1990903847 creator A5004615822 @default.
- W1990903847 creator A5019658954 @default.
- W1990903847 creator A5026360170 @default.
- W1990903847 creator A5059301451 @default.
- W1990903847 creator A5060804731 @default.
- W1990903847 creator A5074783154 @default.
- W1990903847 date "2013-09-01" @default.
- W1990903847 modified "2023-10-12" @default.
- W1990903847 title "Reduced but broader prefrontal activity in patients with schizophrenia during n-back working memory tasks: A multi-channel near-infrared spectroscopy study" @default.
- W1990903847 cites W1983805722 @default.
- W1990903847 cites W1987312539 @default.
- W1990903847 cites W1989297865 @default.
- W1990903847 cites W1990955460 @default.
- W1990903847 cites W1997476282 @default.
- W1990903847 cites W1998496894 @default.
- W1990903847 cites W2017794961 @default.
- W1990903847 cites W2019808522 @default.
- W1990903847 cites W2021620877 @default.
- W1990903847 cites W2022497442 @default.
- W1990903847 cites W2026474458 @default.
- W1990903847 cites W2036398107 @default.
- W1990903847 cites W2041967244 @default.
- W1990903847 cites W2044507990 @default.
- W1990903847 cites W2050147546 @default.
- W1990903847 cites W2068106265 @default.
- W1990903847 cites W2070515441 @default.
- W1990903847 cites W2070991892 @default.
- W1990903847 cites W2103655132 @default.
- W1990903847 cites W2107714488 @default.
- W1990903847 cites W2113371537 @default.
- W1990903847 cites W2120515742 @default.
- W1990903847 cites W2120731293 @default.
- W1990903847 cites W2123510839 @default.
- W1990903847 cites W2123617622 @default.
- W1990903847 cites W2123722617 @default.
- W1990903847 cites W2126475139 @default.
- W1990903847 cites W2140606211 @default.
- W1990903847 cites W2152292563 @default.
- W1990903847 cites W2155125375 @default.
- W1990903847 cites W2161617509 @default.
- W1990903847 cites W2162010696 @default.
- W1990903847 doi "https://doi.org/10.1016/j.jpsychires.2013.05.009" @default.
- W1990903847 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23743135" @default.
- W1990903847 hasPublicationYear "2013" @default.
- W1990903847 type Work @default.
- W1990903847 sameAs 1990903847 @default.
- W1990903847 citedByCount "46" @default.
- W1990903847 countsByYear W19909038472013 @default.
- W1990903847 countsByYear W19909038472014 @default.
- W1990903847 countsByYear W19909038472015 @default.
- W1990903847 countsByYear W19909038472016 @default.
- W1990903847 countsByYear W19909038472017 @default.
- W1990903847 countsByYear W19909038472018 @default.
- W1990903847 countsByYear W19909038472019 @default.
- W1990903847 countsByYear W19909038472020 @default.
- W1990903847 countsByYear W19909038472021 @default.
- W1990903847 countsByYear W19909038472022 @default.
- W1990903847 countsByYear W19909038472023 @default.
- W1990903847 crossrefType "journal-article" @default.
- W1990903847 hasAuthorship W1990903847A5004615822 @default.
- W1990903847 hasAuthorship W1990903847A5019658954 @default.
- W1990903847 hasAuthorship W1990903847A5026360170 @default.
- W1990903847 hasAuthorship W1990903847A5059301451 @default.
- W1990903847 hasAuthorship W1990903847A5060804731 @default.
- W1990903847 hasAuthorship W1990903847A5074783154 @default.
- W1990903847 hasConcept C118552586 @default.
- W1990903847 hasConcept C130796691 @default.
- W1990903847 hasConcept C15744967 @default.
- W1990903847 hasConcept C169760540 @default.
- W1990903847 hasConcept C169900460 @default.
- W1990903847 hasConcept C21963081 @default.
- W1990903847 hasConcept C2776412080 @default.
- W1990903847 hasConcept C2776587650 @default.
- W1990903847 hasConcept C2779226451 @default.
- W1990903847 hasConcept C2780508717 @default.
- W1990903847 hasConcept C2781195155 @default.
- W1990903847 hasConcept C548259974 @default.
- W1990903847 hasConcept C71924100 @default.
- W1990903847 hasConceptScore W1990903847C118552586 @default.
- W1990903847 hasConceptScore W1990903847C130796691 @default.
- W1990903847 hasConceptScore W1990903847C15744967 @default.
- W1990903847 hasConceptScore W1990903847C169760540 @default.
- W1990903847 hasConceptScore W1990903847C169900460 @default.
- W1990903847 hasConceptScore W1990903847C21963081 @default.
- W1990903847 hasConceptScore W1990903847C2776412080 @default.
- W1990903847 hasConceptScore W1990903847C2776587650 @default.
- W1990903847 hasConceptScore W1990903847C2779226451 @default.
- W1990903847 hasConceptScore W1990903847C2780508717 @default.
- W1990903847 hasConceptScore W1990903847C2781195155 @default.
- W1990903847 hasConceptScore W1990903847C548259974 @default.
- W1990903847 hasConceptScore W1990903847C71924100 @default.
- W1990903847 hasIssue "9" @default.
- W1990903847 hasLocation W19909038471 @default.
- W1990903847 hasLocation W19909038472 @default.
- W1990903847 hasOpenAccess W1990903847 @default.
- W1990903847 hasPrimaryLocation W19909038471 @default.