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• W1990930805 abstract "Objectives During implantation of transcatheter aortic valves into severe calcified aortic annuli, misdeployments due to asymmetric shapes of the target region were reported. Whether the resultant stent deformations influence valve performance has not been quantified. The objective of this study was to investigate in vitro hemodynamics of the Edwards Sapien XT (Edwards Lifesciences, Irvine, Calif) after valve deployment in noncircular aortic annuli. Methods Six Edwards Sapien XT valves were implanted into a model of the aortic annulus with different shapes (elliptical, triangular, and bulged compared with ideal circular) and investigated in a pulsatile flow simulator. Leakage was determined by ultrasonic flow measurements, and leaflet coaptation was visualized by high-speed video. In addition, the origin of leakage was investigated under static pressure. Results The lowest amount of leakage occurred in the ideal circular shape, whereas in most of the noncircular configurations increased transvalvular leakage due to paravalvular leaks and folds at the free edges of the leaflets was found, more often by implantation of the valve within a triangular annulus shape. Implantation of the valves into the elliptical configuration with the prosthesis commissure directed to the longitudinal axis of the annular plane showed similar values compared with the circular annulus. Pressure gradients were not influenced by the valve distortion. Conclusions Implantation of the Edwards Sapien XT transcatheter valve into non–circular-shaped aortic annuli leads to increased leakage. Annulus shape and relative position of the prosthesis are main determinants of leakage. Implantation into elliptical annuli, as found in bicuspid aortic valves, seems feasible. During implantation of transcatheter aortic valves into severe calcified aortic annuli, misdeployments due to asymmetric shapes of the target region were reported. Whether the resultant stent deformations influence valve performance has not been quantified. The objective of this study was to investigate in vitro hemodynamics of the Edwards Sapien XT (Edwards Lifesciences, Irvine, Calif) after valve deployment in noncircular aortic annuli. Six Edwards Sapien XT valves were implanted into a model of the aortic annulus with different shapes (elliptical, triangular, and bulged compared with ideal circular) and investigated in a pulsatile flow simulator. Leakage was determined by ultrasonic flow measurements, and leaflet coaptation was visualized by high-speed video. In addition, the origin of leakage was investigated under static pressure. The lowest amount of leakage occurred in the ideal circular shape, whereas in most of the noncircular configurations increased transvalvular leakage due to paravalvular leaks and folds at the free edges of the leaflets was found, more often by implantation of the valve within a triangular annulus shape. Implantation of the valves into the elliptical configuration with the prosthesis commissure directed to the longitudinal axis of the annular plane showed similar values compared with the circular annulus. Pressure gradients were not influenced by the valve distortion. Implantation of the Edwards Sapien XT transcatheter valve into non–circular-shaped aortic annuli leads to increased leakage. Annulus shape and relative position of the prosthesis are main determinants of leakage. Implantation into elliptical annuli, as found in bicuspid aortic valves, seems feasible." @default.
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• W1990930805 date "2014-07-01" @default.
• W1990930805 modified "2023-10-18" @default.
• W1990930805 title "Hemodynamics of the Edwards Sapien XT transcatheter heart valve in noncircular aortic annuli" @default.
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• W1990930805 doi "https://doi.org/10.1016/j.jtcvs.2013.07.057" @default.
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