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- W1990940923 abstract "Advances in molecular biological techniques in recent years have greatly increased our level of understanding about the mechanisms underlying carcinogenesis. Such advances have also enabled identification of genetic mutations associated with specific cancers. It is accepted that this recent acceleration in the discovery of genetic mutations linked to tumour type will have a great impact on clinical practice. However, the translation of such scientific knowledge into patient benefit is by no means clear cut in many instances, and the marriage between new discoveries in basic science and clinical practice— “translational medicine”—is a tremendous challenge. Molecular genetic tests as a guide to surgical management of familial adenomatous polyposisOn this evidence, IRA should be the primary treatment for polyposis in patients with mutations before codon 1250, and RPC in those with mutations after this codon. Full-Text PDF" @default.
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- W1990940923 date "1996-08-01" @default.
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- W1990940923 title "Adenomatous polyposis coli and translational medicine" @default.
- W1990940923 cites W1987317958 @default.
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- W1990940923 doi "https://doi.org/10.1016/s0140-6736(05)64535-7" @default.
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