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- W1990947371 abstract "The distribution of receptor subtypes for endothelin (ET) in the kidney of the freshwater turtle, Amyda japonica, was examined by quantitative in vitro receptor autoradiography using iodinated mammalian type ET‐1 (125I‐ET‐1) as a radiolabeled ligand. Specific 125I‐ET‐1 bindings were localized to renal tubules, renal arteries and ureter with binding densities of 111.21 ± 19.14, 182.13 ± 10.57 and 219.46 ± 12.83 amol/mm2, respectively. Binding dissociation constants in renal tubules, renal arteries and ureter were 1.05 ± 0.63, 2.03±0.56 and 1.70±0.47nM, respectively. Receptor subtypes for ET in the kidney were characterized by competition with BQ 123 and BQ 788 as specific antagonists for ET receptors, type A (ETA), and type B (ETB) subtypes, respectively. Specific 125I‐ET‐1 bindings in renal arteries and ureter were potently inhibited by BQ 123 in a dose‐dependent manner, whereas BQ 788 was not in competing for specific 125I‐ET‐1 bindings in this structure. However, specific 125I‐ET‐1 bindings in renal tub..." @default.
- W1990947371 created "2016-06-24" @default.
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- W1990947371 date "2000-01-01" @default.
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- W1990947371 title "Receptor subtypes for endothelin in the kidney of the freshwater turtle (amyda japonica)" @default.
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- W1990947371 doi "https://doi.org/10.1080/12265071.2000.9647525" @default.
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