Matches in SemOpenAlex for { <https://semopenalex.org/work/W1990956560> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W1990956560 endingPage "29" @default.
- W1990956560 startingPage "19" @default.
- W1990956560 abstract "1. The effects of lobeline (15 to 45 µg/kg) and of local changes of pulmonary artery pressure on the afferent activity of single neurone preparations of pulmonary artery mechanoreceptors have been studied in the intact cat. Pulmonary artery pressure was monitored via a double lumen balloon catheter passed into the pulmonary artery. 2. Pulmonary artery mechanoreceptors were distinguished from systemic mechanoreceptors by applying two simple tests to all mechanoreceptors found by random selection of single fibers from the right cervical vagus. The afferent activity of pulmonary mechanoreceptors closely followed induced changes of pulmonary artery pressure, whereas other arterial mechanoreceptors did not. Pulmonary artery pressure was increased by the rapid injection of 2 ml dextran into the right atrium and was reduced by inflation of the intravascular balloon. 3. In the absence of a rise in pulmonary artery pressure, lobeline increased the afferent activity in two phases. The early response, which was seen in 17 of the 18 fibers studied, occurred within one to two seconds after injection and was characteristically a variable and moderate response. This effect is caused probably by the diffusion of lobeline to sensory endings within the pulmonary artery wall. The delayed response occurred about eight to ten seconds later. The activity of afferent fibers was intensified conspicuously and frequencies up to 300/sec were recorded. It is probable that this is due to the action of lobeline carried by the vasa vasorum to the intramural receptors. 4. By combining the results following balloon inflation and dextran injection, the relationship between impulses per heart beat and mean pulmonary artery pressure was established for a number of pulmonary artery mechanoreceptors in the intact animal. 5. Pulmonary artery mechanoreceptors were insensitive to doses of veratridine and relatively insensitive to doses of phenyldiguanide which, in the intact cat, produce equivalent reflexogenic responses as lobeline (45 µg/kg). 6. Other intrathoracic sensory endings studied, including atrial and ventricular stretch receptors, Hering-Breuer receptors, and systemic mechanoreceptors, were completely insensitive to the doses of lobeline used in these experiments. 7. These results support earlier experiments which suggested that when lobeline is injected, its reflex effect from the pulmonary vascular bed, namely depression of ventilation, is due to its action on a pressure- or stretch-sensitive area in the region of the bifurcation of the pulmonary artery." @default.
- W1990956560 created "2016-06-24" @default.
- W1990956560 creator A5009044687 @default.
- W1990956560 creator A5059089653 @default.
- W1990956560 date "1965-07-01" @default.
- W1990956560 modified "2023-09-25" @default.
- W1990956560 title "Action of Lobeline on Pulmonary Artery Mechanoreceptors of the Cat" @default.
- W1990956560 cites W1521957407 @default.
- W1990956560 cites W1526047926 @default.
- W1990956560 cites W1569070453 @default.
- W1990956560 cites W1969450149 @default.
- W1990956560 cites W2002294768 @default.
- W1990956560 cites W2050468452 @default.
- W1990956560 cites W2058055494 @default.
- W1990956560 cites W2060707121 @default.
- W1990956560 cites W2069874723 @default.
- W1990956560 cites W2071390071 @default.
- W1990956560 cites W2088126449 @default.
- W1990956560 cites W2089208467 @default.
- W1990956560 cites W2092347853 @default.
- W1990956560 cites W2102734012 @default.
- W1990956560 cites W2127807036 @default.
- W1990956560 cites W2132068201 @default.
- W1990956560 cites W2143692440 @default.
- W1990956560 cites W2166750770 @default.
- W1990956560 cites W2269293144 @default.
- W1990956560 cites W2277032190 @default.
- W1990956560 cites W2279731690 @default.
- W1990956560 cites W2402289286 @default.
- W1990956560 cites W2437845752 @default.
- W1990956560 doi "https://doi.org/10.1161/01.res.17.1.19" @default.
- W1990956560 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14302548" @default.
- W1990956560 hasPublicationYear "1965" @default.
- W1990956560 type Work @default.
- W1990956560 sameAs 1990956560 @default.
- W1990956560 citedByCount "14" @default.
- W1990956560 countsByYear W19909565602022 @default.
- W1990956560 crossrefType "journal-article" @default.
- W1990956560 hasAuthorship W1990956560A5009044687 @default.
- W1990956560 hasAuthorship W1990956560A5059089653 @default.
- W1990956560 hasBestOaLocation W19909565601 @default.
- W1990956560 hasConcept C105702510 @default.
- W1990956560 hasConcept C126322002 @default.
- W1990956560 hasConcept C139059822 @default.
- W1990956560 hasConcept C164705383 @default.
- W1990956560 hasConcept C2776512019 @default.
- W1990956560 hasConcept C2776820930 @default.
- W1990956560 hasConcept C2779263132 @default.
- W1990956560 hasConcept C2780940725 @default.
- W1990956560 hasConcept C2993470428 @default.
- W1990956560 hasConcept C42219234 @default.
- W1990956560 hasConcept C71924100 @default.
- W1990956560 hasConceptScore W1990956560C105702510 @default.
- W1990956560 hasConceptScore W1990956560C126322002 @default.
- W1990956560 hasConceptScore W1990956560C139059822 @default.
- W1990956560 hasConceptScore W1990956560C164705383 @default.
- W1990956560 hasConceptScore W1990956560C2776512019 @default.
- W1990956560 hasConceptScore W1990956560C2776820930 @default.
- W1990956560 hasConceptScore W1990956560C2779263132 @default.
- W1990956560 hasConceptScore W1990956560C2780940725 @default.
- W1990956560 hasConceptScore W1990956560C2993470428 @default.
- W1990956560 hasConceptScore W1990956560C42219234 @default.
- W1990956560 hasConceptScore W1990956560C71924100 @default.
- W1990956560 hasIssue "1" @default.
- W1990956560 hasLocation W19909565601 @default.
- W1990956560 hasLocation W19909565602 @default.
- W1990956560 hasOpenAccess W1990956560 @default.
- W1990956560 hasPrimaryLocation W19909565601 @default.
- W1990956560 hasRelatedWork W176835863 @default.
- W1990956560 hasRelatedWork W1964723030 @default.
- W1990956560 hasRelatedWork W1989400088 @default.
- W1990956560 hasRelatedWork W2051544467 @default.
- W1990956560 hasRelatedWork W2064342487 @default.
- W1990956560 hasRelatedWork W2137527564 @default.
- W1990956560 hasRelatedWork W2410291199 @default.
- W1990956560 hasRelatedWork W4210544821 @default.
- W1990956560 hasRelatedWork W2468070720 @default.
- W1990956560 hasRelatedWork W3031396723 @default.
- W1990956560 hasVolume "17" @default.
- W1990956560 isParatext "false" @default.
- W1990956560 isRetracted "false" @default.
- W1990956560 magId "1990956560" @default.
- W1990956560 workType "article" @default.