Matches in SemOpenAlex for { <https://semopenalex.org/work/W1990971027> ?p ?o ?g. }
- W1990971027 abstract "Psoriasis is a chronic disease of the skin characterized by hyper proliferation and inflammation of the epidermis and dermal components of the skin. T-cell-dependent inflammatory process in skin governs the pathogenesis of psoriasis. An in-silico search strategy was utilized to identify psoriatic therapeutic drug targets. The gene expression profiling of psoriatic skin identified a total of 427 differentially expressed genes (DEGs). Gene ontology investigation of DEGs identified genes involved in calcium binding, apoptosis, keratinisation, lipid transportation and homeostasis apart from immune mediated processes. The protein interaction networks identified proteins involved in various signaling mechanisms with high degree of interconnections. The gene modules derived from the main network were enriched with rich kinome. These sub-networks were dominated by the presence of non-receptor kinase family members which are major signal transmitters in immune response. The computational approach has aided in the identification of non-receptor kinases as potential targets for psoriasis drug development." @default.
- W1990971027 created "2016-06-24" @default.
- W1990971027 creator A5029605751 @default.
- W1990971027 creator A5053581026 @default.
- W1990971027 creator A5057026923 @default.
- W1990971027 date "2015-07-01" @default.
- W1990971027 modified "2023-09-25" @default.
- W1990971027 title "Insights into protein interaction networks reveal non-receptor kinases as significant druggable targets for psoriasis" @default.
- W1990971027 cites W1483308173 @default.
- W1990971027 cites W1490343462 @default.
- W1990971027 cites W1515431598 @default.
- W1990971027 cites W1547586682 @default.
- W1990971027 cites W1967965268 @default.
- W1990971027 cites W1981070546 @default.
- W1990971027 cites W1985841356 @default.
- W1990971027 cites W1995117548 @default.
- W1990971027 cites W2002117801 @default.
- W1990971027 cites W2007076203 @default.
- W1990971027 cites W2010050195 @default.
- W1990971027 cites W2010457001 @default.
- W1990971027 cites W2025888803 @default.
- W1990971027 cites W2028142016 @default.
- W1990971027 cites W2032466268 @default.
- W1990971027 cites W2032576198 @default.
- W1990971027 cites W2033898797 @default.
- W1990971027 cites W2037682763 @default.
- W1990971027 cites W2050509360 @default.
- W1990971027 cites W2059958613 @default.
- W1990971027 cites W2063638849 @default.
- W1990971027 cites W2072488504 @default.
- W1990971027 cites W2074360288 @default.
- W1990971027 cites W2076224384 @default.
- W1990971027 cites W2083589812 @default.
- W1990971027 cites W2092382665 @default.
- W1990971027 cites W2092868481 @default.
- W1990971027 cites W2093943502 @default.
- W1990971027 cites W2094583929 @default.
- W1990971027 cites W2103453943 @default.
- W1990971027 cites W2112947018 @default.
- W1990971027 cites W2116634113 @default.
- W1990971027 cites W2122683221 @default.
- W1990971027 cites W2132041082 @default.
- W1990971027 cites W2134668392 @default.
- W1990971027 cites W2134819768 @default.
- W1990971027 cites W2137665452 @default.
- W1990971027 cites W2146512944 @default.
- W1990971027 cites W2150414518 @default.
- W1990971027 cites W2155729698 @default.
- W1990971027 cites W2156070536 @default.
- W1990971027 cites W2159675211 @default.
- W1990971027 cites W2163480486 @default.
- W1990971027 cites W2167779091 @default.
- W1990971027 cites W2168384861 @default.
- W1990971027 doi "https://doi.org/10.1016/j.gene.2015.04.030" @default.
- W1990971027 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25881869" @default.
- W1990971027 hasPublicationYear "2015" @default.
- W1990971027 type Work @default.
- W1990971027 sameAs 1990971027 @default.
- W1990971027 citedByCount "9" @default.
- W1990971027 countsByYear W19909710272017 @default.
- W1990971027 countsByYear W19909710272019 @default.
- W1990971027 countsByYear W19909710272020 @default.
- W1990971027 countsByYear W19909710272021 @default.
- W1990971027 crossrefType "journal-article" @default.
- W1990971027 hasAuthorship W1990971027A5029605751 @default.
- W1990971027 hasAuthorship W1990971027A5053581026 @default.
- W1990971027 hasAuthorship W1990971027A5057026923 @default.
- W1990971027 hasConcept C104317684 @default.
- W1990971027 hasConcept C10679952 @default.
- W1990971027 hasConcept C184235292 @default.
- W1990971027 hasConcept C203014093 @default.
- W1990971027 hasConcept C2780564577 @default.
- W1990971027 hasConcept C502942594 @default.
- W1990971027 hasConcept C54174078 @default.
- W1990971027 hasConcept C54355233 @default.
- W1990971027 hasConcept C62478195 @default.
- W1990971027 hasConcept C70721500 @default.
- W1990971027 hasConcept C86803240 @default.
- W1990971027 hasConcept C95444343 @default.
- W1990971027 hasConceptScore W1990971027C104317684 @default.
- W1990971027 hasConceptScore W1990971027C10679952 @default.
- W1990971027 hasConceptScore W1990971027C184235292 @default.
- W1990971027 hasConceptScore W1990971027C203014093 @default.
- W1990971027 hasConceptScore W1990971027C2780564577 @default.
- W1990971027 hasConceptScore W1990971027C502942594 @default.
- W1990971027 hasConceptScore W1990971027C54174078 @default.
- W1990971027 hasConceptScore W1990971027C54355233 @default.
- W1990971027 hasConceptScore W1990971027C62478195 @default.
- W1990971027 hasConceptScore W1990971027C70721500 @default.
- W1990971027 hasConceptScore W1990971027C86803240 @default.
- W1990971027 hasConceptScore W1990971027C95444343 @default.
- W1990971027 hasLocation W19909710271 @default.
- W1990971027 hasLocation W19909710272 @default.
- W1990971027 hasOpenAccess W1990971027 @default.
- W1990971027 hasPrimaryLocation W19909710271 @default.
- W1990971027 hasRelatedWork W2009500663 @default.
- W1990971027 hasRelatedWork W2023327385 @default.
- W1990971027 hasRelatedWork W2156130452 @default.
- W1990971027 hasRelatedWork W2925167008 @default.
- W1990971027 hasRelatedWork W2947496730 @default.