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- W1990973189 abstract "Changes in microglial cell activation and distribution are associated with neuronal decline in the central nervous system (CNS), particularly under pathological conditions. Activated microglia converge on the initial site of axonal degeneration in human glaucoma, yet their part in its pathophysiology remains unresolved. To begin with, it is unknown whether microglia activation precedes or is a late consequence of retinal ganglion cell (RGC) neurodegeneration. Here we address this critical element in DBA/2J (D2) mice, an established model of chronic inherited glaucoma, using as a control the congenic substrain DBA/2J Gpnmb(+/SjJ) (D2G), which is not affected by glaucoma. We analyzed the spatial distribution and timecourse of microglial changes in the retina, as well as within the proximal optic nerve prior to and throughout ages when neurodegeneration has been reported. Exclusively in D2 mice, we detected early microglia clustering in the inner central retina and unmyelinated optic nerve regions, with microglia activation peaking by 3 months of age. Between 5 and 8 months of age, activated microglia persisted and concentrated in the optic disc, but also localized to the retinal periphery. Collectively, our findings suggest microglia activation is an early alteration in the retina and optic nerve in D2 glaucoma, potentially contributing to disease onset or progression. Ultimately, detection of microglial activation may have value in early disease diagnosis, while modulation of microglial responses may alter disease progression." @default.
- W1990973189 created "2016-06-24" @default.
- W1990973189 creator A5012275431 @default.
- W1990973189 creator A5028079932 @default.
- W1990973189 creator A5036709120 @default.
- W1990973189 date "2011-01-18" @default.
- W1990973189 modified "2023-09-30" @default.
- W1990973189 title "Early microglia activation in a mouse model of chronic glaucoma" @default.
- W1990973189 cites W1504492140 @default.
- W1990973189 cites W1513702808 @default.
- W1990973189 cites W1553218248 @default.
- W1990973189 cites W1583737662 @default.
- W1990973189 cites W1593213689 @default.
- W1990973189 cites W1599123965 @default.
- W1990973189 cites W1894872962 @default.
- W1990973189 cites W1912834410 @default.
- W1990973189 cites W1964675499 @default.
- W1990973189 cites W1966228318 @default.
- W1990973189 cites W1974456051 @default.
- W1990973189 cites W1974626393 @default.
- W1990973189 cites W1977155385 @default.
- W1990973189 cites W1978392572 @default.
- W1990973189 cites W1980292391 @default.
- W1990973189 cites W1983422848 @default.
- W1990973189 cites W1986089665 @default.
- W1990973189 cites W1987876121 @default.
- W1990973189 cites W1991248117 @default.
- W1990973189 cites W1991343786 @default.
- W1990973189 cites W1991685992 @default.
- W1990973189 cites W1992902368 @default.
- W1990973189 cites W1993411739 @default.
- W1990973189 cites W1995776351 @default.
- W1990973189 cites W1996114536 @default.
- W1990973189 cites W1997875633 @default.
- W1990973189 cites W1999494818 @default.
- W1990973189 cites W1999504203 @default.
- W1990973189 cites W1999700873 @default.
- W1990973189 cites W2000119650 @default.
- W1990973189 cites W2000711529 @default.
- W1990973189 cites W2003674452 @default.
- W1990973189 cites W2004349171 @default.
- W1990973189 cites W2005918555 @default.
- W1990973189 cites W2006134282 @default.
- W1990973189 cites W2009740514 @default.
- W1990973189 cites W2019278127 @default.
- W1990973189 cites W2019885109 @default.
- W1990973189 cites W2020083484 @default.
- W1990973189 cites W2022209206 @default.
- W1990973189 cites W2022417898 @default.
- W1990973189 cites W2026733101 @default.
- W1990973189 cites W2028112133 @default.
- W1990973189 cites W2029429049 @default.
- W1990973189 cites W2029994336 @default.
- W1990973189 cites W2031743055 @default.
- W1990973189 cites W2034060753 @default.
- W1990973189 cites W2034842977 @default.
- W1990973189 cites W2040275472 @default.
- W1990973189 cites W2042743192 @default.
- W1990973189 cites W2045291414 @default.
- W1990973189 cites W2049448622 @default.
- W1990973189 cites W2049862190 @default.
- W1990973189 cites W2050568671 @default.
- W1990973189 cites W2050697792 @default.
- W1990973189 cites W2052439242 @default.
- W1990973189 cites W2053554709 @default.
- W1990973189 cites W2055335620 @default.
- W1990973189 cites W2055741851 @default.
- W1990973189 cites W2057793110 @default.
- W1990973189 cites W2059088084 @default.
- W1990973189 cites W2060710997 @default.
- W1990973189 cites W2060713539 @default.
- W1990973189 cites W2060742460 @default.
- W1990973189 cites W2062457533 @default.
- W1990973189 cites W2063827358 @default.
- W1990973189 cites W2065142041 @default.
- W1990973189 cites W2065688555 @default.
- W1990973189 cites W2066478570 @default.
- W1990973189 cites W2068232370 @default.
- W1990973189 cites W2069660062 @default.
- W1990973189 cites W2073161602 @default.
- W1990973189 cites W2082755707 @default.
- W1990973189 cites W2083672927 @default.
- W1990973189 cites W2085667648 @default.
- W1990973189 cites W2086863589 @default.
- W1990973189 cites W2087647596 @default.
- W1990973189 cites W2088183665 @default.
- W1990973189 cites W2090494985 @default.
- W1990973189 cites W2094052724 @default.
- W1990973189 cites W2096327192 @default.
- W1990973189 cites W2108973467 @default.
- W1990973189 cites W2112516157 @default.
- W1990973189 cites W2117568221 @default.
- W1990973189 cites W2123598898 @default.
- W1990973189 cites W2127235616 @default.
- W1990973189 cites W2129008615 @default.
- W1990973189 cites W2129843248 @default.
- W1990973189 cites W2130436599 @default.
- W1990973189 cites W2131617973 @default.